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Sustained antibacterial hemostatic powder and preparation method thereof

A technology of hemostatic powder and sodium carboxymethyl cellulose, which is applied in the fields of pharmaceutical formulation, application, and medical science, can solve the problems of antimicrobial drug resistance, the difficulty of hemostatic materials with antibacterial functions, etc., and achieve excellent hemostatic function, Excellent antibacterial performance, effect of increasing concentration

Inactive Publication Date: 2017-03-22
GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, it is generally difficult for existing hemostatic materials to have antibacterial functions. Most of the hemostatic materials generally add antibacterial drugs in order to have antibacterial functions, but this has the problem of antibacterial drug resistance.

Method used

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  • Sustained antibacterial hemostatic powder and preparation method thereof
  • Sustained antibacterial hemostatic powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A continuous antibacterial hemostatic powder with nano silver, sodium carboxymethyl cellulose and sodium alginate as raw materials, composed of nano silver and sodium carboxymethyl cellulose / sodium alginate composite microspheres, nano silver evenly distributed in the carboxymethyl In the framework of sodium cellulose / sodium alginate composite microspheres, the shape of the continuous antibacterial and hemostatic powder is spherical, and the average particle size is 200 μm to 400 μm. The raw materials are calculated in parts by weight: 1 part of nano-silver, 10 parts of sodium carboxymethyl cellulose, and 5 parts of sodium alginate.

[0024] The preparation method of the above-mentioned continuous antibacterial and hemostatic powder is as follows:

[0025] S1, dissolving 10 parts of sodium carboxymethylcellulose in 100ml distilled water to make sodium carboxymethylcellulose solution;

[0026] S2, add 0.2 parts of surfactant Tween-80 and 1 part of nano-silver to the sod...

Embodiment 2

[0030] A continuous antibacterial hemostatic powder with nano silver, sodium carboxymethyl cellulose and sodium alginate as raw materials, composed of nano silver and sodium carboxymethyl cellulose / sodium alginate composite microspheres, nano silver evenly distributed in the carboxymethyl In the framework of sodium cellulose / sodium alginate composite microspheres, the shape of the continuous antibacterial and hemostatic powder is spherical, and the average particle size is 200 μm to 400 μm. The raw materials are calculated in parts by weight: 2 parts of nano-silver, 15 parts of sodium carboxymethyl cellulose, and 8 parts of sodium alginate.

[0031] The preparation method of the above-mentioned continuous antibacterial and hemostatic powder is as follows:

[0032] S1, dissolving 15 parts of sodium carboxymethyl cellulose in 100ml distilled water to make a sodium carboxymethyl cellulose solution;

[0033] S2, add 1 part of surfactant Tween-80 and 2 parts of nano-silver to the ...

Embodiment 3

[0037] A continuous antibacterial hemostatic powder with nano silver, sodium carboxymethyl cellulose and sodium alginate as raw materials, composed of nano silver and sodium carboxymethyl cellulose / sodium alginate composite microspheres, nano silver evenly distributed in the carboxymethyl In the framework of sodium cellulose / sodium alginate composite microspheres, the shape of the continuous antibacterial and hemostatic powder is spherical, and the average particle size is 200 μm to 400 μm. The raw materials are calculated in parts by weight: 3 parts of nano-silver, 20 parts of sodium carboxymethyl cellulose, and 10 parts of sodium alginate.

[0038] The preparation method of the above-mentioned continuous antibacterial and hemostatic powder is as follows:

[0039] S1, dissolving 20 parts of sodium carboxymethylcellulose in 100ml distilled water to make sodium carboxymethylcellulose solution;

[0040] S2, add 2 parts of surfactant Tween-80 and 3 parts of nano-silver to the so...

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Abstract

The invention belongs to the field of medical equipment, particularly relates to the field of medical biopolymer materials and provides sustained antibacterial hemostatic powder and a preparation method of the sustained antibacterial hemostatic powder. The sustained antibacterial hemostatic powder is prepared from nanometer silver, sodium carboxymethyl cellulose and alginate, and by weight, 1-3 parts of the nanometer silver, 10-20 parts of the sodium carboxymethyl cellulose and 5-10 parts of the alginate are included. According to the sustained antibacterial hemostatic powder, the nanometer silver, the sodium carboxymethyl cellulose and the alginate are used as the raw materials, and the sustained antibacterial hemostatic powder is obtained through a spray drying method; and the hemostatic powder not only has the hemostatic function, but also has the excellent antibacterial function, as degradation of the sodium carboxymethyl cellulose and the alginate after the hemostatic powder is in contact with the blood or diffusate, the contained nanometer silver is released slowly, and thus the sustained antibacterial purpose is achieved.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to the field of medical biopolymer materials, and specifically relates to a continuous antibacterial hemostatic powder and a preparation method thereof. Background technique [0002] Bleeding is a prominent manifestation of trauma, and hemostasis is the basic task of trauma rescue. Effective hemostasis can reduce bleeding, preserve effective blood volume, and prevent shock. Therefore, timely and effective hemostasis is an important technology to save lives, reduce mortality, and win further treatment time for the wounded. In addition, due to the formation of a warm and humid environment on the surface of the wound, pathogens such as Staphylococcus aureus, Candida albicans, and Escherichia coli can multiply quickly on the wound and easily cause wound infection. Therefore, while stopping bleeding, wound infection should also be avoided. [0003] However, it is generally difficult for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/00
CPCA61L24/08A61L24/0015A61L24/02A61L2300/104A61L2300/232A61L2300/418A61L2300/622C08L5/04C08L1/286
Inventor 卢亢韦加娜吴帅
Owner GUANGDONG TAIBAO MEDICAL DEVICE TECH RES INST CO LTD
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