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Antimicrobial disinfectant with good biocompatibility

A biocompatible and antimicrobial technology, applied in the field of antimicrobial polymer materials, can solve the problems of unsustainable antibacterial effect, super bacteria, secondary infection of the body, etc., achieve long-term antimicrobial effect and promote tissue cell regeneration , good biocompatibility

Inactive Publication Date: 2017-03-15
克灵美(天津)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] At present, pathogenic microorganisms are becoming more and more serious due to their drug resistance, especially the superbugs caused by drug resistance discovered in recent years have no drugs available, directly threatening human safety
In the face of such a severe situation, although there are many types of antimicrobial disinfection products in the market, due to the similar structure of human cells and bacteria, antibacterial products that can generally kill bacteria also have a killing effect on body cells, which makes traditional antimicrobial disinfection products There are many problems. For example, those with excellent antibacterial properties also have strong toxic and side effects and irritation to the normal body. This type of product is prominently displayed on high-efficiency disinfectants such as traditional small molecule antibacterial disinfectants and heavy metal antibacterial disinfectants; some products Also serious to environmental pollution and expensive, as the silver-based antibacterial sterilization product of U.S.Silver Protection Systems, Inc. (U.S.Silver Protection Systems, Inc.) and the antibacterial product of the same kind of BASF of Germany etc.; , although the toxicity and irritation to the body are relatively small, such as small molecule quaternary ammonium salts or quaternary ammonium salt compound disinfectants, their antibacterial effects are often not durable, or the antibacterial and disinfection effects are poor. In the case of strict sterilization, because Inability to completely kill bacteria can easily lead to the generation of superbugs, and even directly lead to the death of normal organisms due to secondary infections that cannot be cured, or their application range is limited because of their poor broad-spectrum antibacterial properties; while the currently reported high Molecular quaternary ammonium salt antibacterial agent has improved antibacterial persistence, but its antibacterial performance is too mild, such as CN103535372A patent, such as organosilicon quaternary ammonium salt antibacterial rate is generally about 95%
In order to improve its antibacterial properties, such as CN102246753 patent, it is often necessary to add other ingredients as synergists to introduce ingredients with strong toxicity, side effects or environmental pollution, such as small molecule antibacterial agents, metal complexes, etc. Therefore, many reasons As a result, it cannot be applied to wound disinfection, anti-infection, medical device disinfection and environmental disinfection that require strict sterilization

Method used

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  • Antimicrobial disinfectant with good biocompatibility
  • Antimicrobial disinfectant with good biocompatibility
  • Antimicrobial disinfectant with good biocompatibility

Examples

Experimental program
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Effect test

Embodiment 1

[0060] An antimicrobial disinfectant with good biocompatibility: including antimicrobial polymers, wherein the antimicrobial polymers are: straight-chain polyhydroxyethyl acrylate polymers as the backbone, with a molecular weight of about 28,000, antimicrobial The molar ratio of the branched chains of the functional groups and the branched chains of the biocompatible functional groups is 2:8, and the grafting rate of the branched chains of the antimicrobial functional groups is 20%. The structure of the branched chain of the antimicrobial functional group is I, where R 1 =CH 3 , R 2 =R 3 =C 12 h 25 , Y=CH 2 , d=3, e=0, M=N (nitrogen), The branched chain of the biocompatible functional group is a polyethylene oxide oligomer with a polymerization degree of 5; the solvent is deionized water. This antimicrobial disinfectant preparation method is:

[0061] Place the antimicrobial polymer in deionized water at room temperature, stir evenly until the polymer is completely di...

Embodiment 2

[0065] An antimicrobial disinfectant with good biocompatibility, including antimicrobial polymers, wherein the antimicrobial polymer structure is: fully synthetic polytetrahydrofuran as the polymer backbone, the molecular weight is about 2700Da, and the antimicrobial functional group is branched. The ratio is 69.8%, and the molar ratio of the branched chains of antimicrobial functional groups and the branched chains of biocompatible functional groups is 7:3. Wherein, the structure of the branched chain of the antimicrobial functional group is one of the structures represented by formula III, specifically R in formula III 6 =R 7 =CH 3 , R 8 =H,Z=CH 2 , f=3, g=0; the branched chain of the biocompatible functional group is one of the structures represented by formula IV, specifically R in formula IV 11 =R 12 =R 13 =R 14 =R 15 =R 16 =H, h=r=2, j=i=1, U=OC(O), Q=O, T=OCH 3 , the solvent is phosphate buffered saline (PBS). This antimicrobial disinfectant preparation metho...

Embodiment 3

[0070] An antimicrobial disinfectant with good biocompatibility, including an antimicrobial polymer, wherein the antimicrobial polymer structure is: a straight-chain polyhydroxyethyl acrylate polymer as a skeleton, a molecular weight of about 28,000, and an antimicrobial polymer. The molar ratio of the branched chains of the microbial functional groups to the branched chains of the biocompatible functional groups is 2:8, and the grafting rate of the branched chains of the antimicrobial functional groups is 20%. The structure of the branched chain of the antimicrobial functional group is I, where R 1 =CH 3 , R 2 =R 3 =C 12 h 25 , Y=CH 2 , d=3, e=0, M=N (nitrogen), The branch chain of the biocompatible functional group is a polyethylene oxide oligomer with a polymerization degree of 5; the solvent is 0.09wt% physiological saline. This antimicrobial disinfectant preparation method is:

[0071] Dissolve the antimicrobial polymer in deionized water at 50°C, and stir evenly...

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Abstract

The invention discloses an antimicrobial disinfectant with good biocompatibility. The antimicrobial disinfectant includes: 0.001wt%-100wt% of an antimicrobial macromolecule; 0wt%-99.999wt% of an assistant; and 0wt%-99.999wt% of a solvent. The antimicrobial disinfectant provided by the invention has the characteristics of simple components and easy preparation; long-acting and rapid killing and inhibiting effect on gram positive pathogenic bacteria, gram negative pathogenic bacteria, moulds, fungi, viruses and other microorganisms selectively; no toxic or side effect on normal animal body cells and tissues; no irritation on the human body; auxiliary hemostasis and coagulation, and promotion of cell tissue regeneration, acceleration of wound healing, and no drug resistance; and no pollution to the environment, thus being a widely applicable, economical, environment-friendly and safe antimicrobial disinfectant.

Description

technical field [0001] The invention belongs to the technical field of antimicrobial macromolecular materials, and relates to an antimicrobial disinfection with biocompatible antimicrobial macromolecule as the base material, which has no toxic and side effects on the human body, broad-spectrum, long-term and high-efficiency antimicrobial performance agent. Background technique [0002] At present, pathogenic microorganisms are becoming more and more serious due to their drug resistance, especially the superbugs caused by drug resistance discovered in recent years have no drugs available, directly threatening human safety. In the face of such a severe situation, although there are many types of antimicrobial disinfection products in the market, due to the similar structure of human cells and bacteria, antibacterial products that can generally kill bacteria also have a killing effect on body cells, which makes traditional antimicrobial disinfection products There are many pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/785A61K31/732A61P31/00A61P17/02
CPCA61K31/785A61K31/732
Inventor 曾小梅陈江敏文学军
Owner 克灵美(天津)生物科技有限公司
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