Method and application for preparing fully degradable chitosan hemostatic powder by spray drying process

A technology of spray drying and chitosan, which is applied in the field of medical hemostatic auxiliary materials, can solve cumbersome and time-consuming problems, and achieve the effects of simple operation, convenient preparation, and shortened healing time

Inactive Publication Date: 2016-11-16
NANJING UNIVERSTIY SUZHOU HIGH TECH INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

All of the above technologies require the preparation of chitosan hemostatic powder by the cumbersome and time-consuming inverse emulsion method, and the addition of different cross-linking agents to cross-link and solidify the hemostatic powder

Method used

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  • Method and application for preparing fully degradable chitosan hemostatic powder by spray drying process
  • Method and application for preparing fully degradable chitosan hemostatic powder by spray drying process
  • Method and application for preparing fully degradable chitosan hemostatic powder by spray drying process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A preparation method of absorbable single-component chitosan blood powder is as follows:

[0029] (1) Weigh 7 grams of chitosan, dissolve it in 1 L, 10 g / L of acetic acid solution, and configure it into a 7 g / L chitosan solution. The pH of the solution was 4.5.

[0030] (2) The chitosan solution of the above-mentioned configuration is spray-dried, adopting the B-290 spray drying instrument of Swiss buchi company, the nozzle diameter is 0.5mm, the inlet temperature is 180°C, the outlet temperature is 105°C, and the spray speed is 5mL / min , The compressed air speed is 10L / min. Collect powder product, yield 80%

[0031] (3) Configure 1% citric acid solution, and spray evenly on the surface of the above-mentioned powder product after being atomized by a medical nebulizer. Take 0.1 g of the modified powder sample, disperse it in 5 mL of distilled water, and measure the pH value. When the pH value is between 4-5.5, the modification is complete. Store the hemostatic porti...

Embodiment 2

[0033] A preparation method of absorbable single-component chitosan blood powder is as follows:

[0034] (1) Weigh 6 grams of carboxymethyl chitosan, dissolve it in 1 L, 1 g / L of acetic acid solution, and configure it into a 6 g / L chitosan solution. The pH of the solution was 5.0.

[0035] (2) Spray-dry the carboxymethyl chitosan solution configured above, using a B-290 spray dryer from Buchi, Switzerland, with a nozzle diameter of 1mm, an inlet temperature of 160°C, an outlet temperature of 105°C, and a spray speed of 7mL / min, the compressed air speed is 12L / min. Collect powder product, yield 82%

[0036] (3) Configure 1% citric acid solution, and spray evenly on the surface of the above-mentioned powder product after being atomized by a medical nebulizer. Take 0.1 g of the modified powder sample, disperse it in 5 mL of distilled water, and measure the pH value. When the pH value is between 4-5.5, the modification is complete. Store the hemostatic portion after disinfec...

Embodiment 3

[0038] A kind of preparation method of absorbable multicomponent chitosan blood powder is as follows:

[0039] (1) Weigh 7 grams of chitosan, dissolve it in 1 L, 10 g / L of acetic acid solution, and configure it into a 7 g / L chitosan solution. The pH of the solution was 4.5.

[0040] (2) Prepare an aqueous solution of polyvinyl alcohol, whose mass fraction is 1 g / L. The above-mentioned chitosan solution and polyvinyl alcohol aqueous solution are configured into a mixed solution, and the volume ratio: chitosan solution: polyvinyl alcohol solution is 1:1 (volume ratio).

[0041] (3) Spray-dry the mixed chitosan solution of the above-mentioned configuration, adopt the B-290 spray dryer of Buchi Company in Switzerland, the nozzle diameter is 1mm, the inlet temperature is 160°C, the outlet temperature is 105°C, and the spray speed is 10mL / min , The compressed air speed is 12L / min. Collect powder product, yield 90%

[0042] (4) Configure 1% lactic acid solution, and spray evenly ...

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Abstract

Fully degradable chitosan hemostatic powder is disclosed. The hemostatic powder is chitosan, or composition of chitosan or / and other substance. The other component can be one or more of PVP, hyaluronic acid and oxidized starch. The particle diameter of the chitosan hemostatic powder is in the range of 20 micrometers to 2 millimeters. The chitosan hemostatic powder is porous microballs. The chitosan hemostatic powder is prepared with the spray drying process through chitosan or carboxymethyl chitosan solution of 5-10 g / L of mass fraction, and pH value of the solution is in the range of 4.0-7.4. The solvent used is distilled water or acetum, and the mass fraction of acetum is 10g / L. The prepared chitosan solution is subjected to spray drying, and powder is collected under the conditions that the caliber of the solution is 0.2-2 mm, inlet temperature is 160-180 DEG C, outlet temperature is 100-105 DEG C, and spray speed is 3-10 mL / min.

Description

technical field [0001] The invention relates to the technical field of medical hemostatic auxiliary materials, in particular to a chitosan hemostatic powder and a preparation method and application thereof. Background technique [0002] Hemostasis is an important step in medical treatment. Sufficient hemostasis is required for damage to the liver, spleen and other tissues and organs of patients and surgery. When sudden trauma occurs in daily life, rapid hemostasis is also required. In harsh war environments and complex emergencies It is particularly important to achieve rapid and effective hemostasis in the first aid treatment of trauma in the event. The hemostatic materials currently on the market mainly include fibrin glue, collagen (such as gelatin sponge), and microporous inorganic materials. However, these materials also have some disadvantages, such as: high cost, poor tissue adhesion, and limited hemostatic effect; and porous materials will release a large amount of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/06A61L24/00
CPCA61L24/08A61L24/001A61L24/0036A61L24/0042A61L24/06A61L2400/04C08L5/08C08L29/04
Inventor 胡勇沈旭杰
Owner NANJING UNIVERSTIY SUZHOU HIGH TECH INST
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