Preparation method of polyelectrolyte hemostatic powder based on carboxymethyl chitosan

A technology of carboxymethyl chitosan and polyelectrolyte, which is applied in the field of preparation of polyelectrolyte hemostatic powder, can solve the problems that hemostatic methods and hemostatic drugs cannot meet the requirements, and achieve good biocompatibility, biodegradability, particle size and the like. Small, excellent antibacterial effect

Inactive Publication Date: 2017-03-01
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The object of the present invention is to provide a kind of preparation method of polyelectrolyte hemostatic powder based on carboxymethyl chitosan, the obtained polyelectrolyte hemostatic powder shows excellent hemostatic function, solves the problem that existing conventional hemostatic methods and hemostatic drugs cannot meet the requirements And other issues

Method used

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preparation example Construction

[0027]In a specific embodiment, the preparation method of polyelectrolyte hemostatic powder based on carboxymethyl chitosan of the present invention, first dissolve carboxymethyl chitosan and biocompatible anionic polyelectrolyte or amphoteric polyelectrolyte in deionized water. By reducing the pH value of the polyelectrolyte mixture aqueous solution, the amino groups of carboxymethyl chitosan molecules are protonated, and interact with anionic polyelectrolytes or amphoteric polyelectrolytes to form complexes through Coulomb force. After the polyelectrolyte complex is dried and pulverized, carboxymethyl chitosan polyelectrolyte hemostatic powder is obtained. The specific steps are:

[0028] 1) Prepare an aqueous polyelectrolyte mixture solution containing carboxymethyl chitosan and anionic polyelectrolyte or amphoteric polyelectrolyte. Anionic polyelectrolytes or amphoteric polyelectrolytes are biocompatible polyelectrolytes containing -COO - 、-SO 3- 、-O-CS 2- ,-O-PO 3 ...

Embodiment 1

[0033] 12 grams of carboxymethyl chitosan, 13 grams of sodium polyacrylate and 1 g of gluconolactone were dissolved in 1 liter of deionized water and kept at 50°C for 10 hours. After the polyelectrolyte complex was dried in a blast dryer at 70° C. for 40 hours, it was ball-milled for 1 hour with a ball mill to obtain carboxymethyl chitosan polyelectrolyte hemostatic powder. The hemostatic powder has good biocompatibility and antibacterial property, and exhibits excellent hemostatic function. The measurement of coagulation index in vitro in this embodiment shows that the coagulation index in vitro is <49%; the hemostatic effect test result of the rabbit ear artery bleeding model shows that the hemostatic time is <95 seconds.

Embodiment 2

[0035] 12 grams of carboxymethyl chitosan, 10 grams of hyaluronic acid and 1 g of gluconolactone were dissolved in 1 liter of deionized water and kept at 50°C for 10 hours. After the polyelectrolyte complex was dried in a blast dryer at 70° C. for 40 hours, it was ball-milled for 1 hour with a ball mill to obtain carboxymethyl chitosan polyelectrolyte hemostatic powder. The hemostatic powder has good biocompatibility and antibacterial property, and exhibits excellent hemostatic function. The measurement of coagulation index in vitro in this embodiment shows that the coagulation index in vitro is <65%; the hemostatic effect test result of the rabbit ear artery bleeding model shows that the hemostatic time is <112 seconds.

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Abstract

The invention belongs to the field of preparation of biomedical materials, and relates to a preparation method of a polyelectrolyte hemostatic powder based on carboxymethyl chitosan. The method includes the steps of: dissolving the carboxymethyl chitosan and an anionic polyelectrolyte or an amphoteric polyelectrolyte having biocompatibility in deionized water; forming a compound by reducing the pH value of the polyelectrolyte solution so as to protonize the amino groups in the carboxymethyl chitosan molecules, wherein the protonized amino groups are interacted with the anionic polyelectrolyte or the amphoteric polyelectrolyte through Coulomb force; and drying and crushing the polyelectrolyte compound to prepare the carboxymethyl chitosan polyelectrolyte hemostatic powder. The hemostatic powder has excellent biocompatibility and antibacterial property and has excellent hemostatic function.

Description

technical field [0001] The invention belongs to the field of biomedical material preparation, and relates to a preparation method of polyelectrolyte hemostatic powder based on carboxymethyl chitosan. Background technique [0002] Modern medical theory proves that wound healing is a continuous dynamic process of cell-to-cell, cell-to-cell matrix, and soluble media interactions. Wound repair is related to the interaction of local tissue nutrition, microenvironment, growth factor content, microcirculation, hypoxic conditions, infection and other factors, and medical dressings can play a key role. As a main theoretical basis of high-tech medical dressings, the "wet therapy" discovered by British scientists in 1962 believes that when the surface of the wound is maintained in a moist microenvironment, the migration of epithelial cells is significantly accelerated, and the healing speed of the wound is faster than that of wounds. Fast in dry conditions. [0003] Blood is an impor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/24A61L15/32A61L15/44A61L26/00
Inventor 赵岩张劲松
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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