Preparation method of polyelectrolyte hemostatic powder based on carboxymethyl chitosan
A technology of carboxymethyl chitosan and polyelectrolyte, which is applied in the field of preparation of polyelectrolyte hemostatic powder, can solve the problems that hemostatic methods and hemostatic drugs cannot meet the requirements, and achieve good biocompatibility, biodegradability, particle size and the like. Small, excellent antibacterial effect
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[0027]In a specific embodiment, the preparation method of polyelectrolyte hemostatic powder based on carboxymethyl chitosan of the present invention, first dissolve carboxymethyl chitosan and biocompatible anionic polyelectrolyte or amphoteric polyelectrolyte in deionized water. By reducing the pH value of the polyelectrolyte mixture aqueous solution, the amino groups of carboxymethyl chitosan molecules are protonated, and interact with anionic polyelectrolytes or amphoteric polyelectrolytes to form complexes through Coulomb force. After the polyelectrolyte complex is dried and pulverized, carboxymethyl chitosan polyelectrolyte hemostatic powder is obtained. The specific steps are:
[0028] 1) Prepare an aqueous polyelectrolyte mixture solution containing carboxymethyl chitosan and anionic polyelectrolyte or amphoteric polyelectrolyte. Anionic polyelectrolytes or amphoteric polyelectrolytes are biocompatible polyelectrolytes containing -COO - 、-SO 3- 、-O-CS 2- ,-O-PO 3 ...
Embodiment 1
[0033] 12 grams of carboxymethyl chitosan, 13 grams of sodium polyacrylate and 1 g of gluconolactone were dissolved in 1 liter of deionized water and kept at 50°C for 10 hours. After the polyelectrolyte complex was dried in a blast dryer at 70° C. for 40 hours, it was ball-milled for 1 hour with a ball mill to obtain carboxymethyl chitosan polyelectrolyte hemostatic powder. The hemostatic powder has good biocompatibility and antibacterial property, and exhibits excellent hemostatic function. The measurement of coagulation index in vitro in this embodiment shows that the coagulation index in vitro is <49%; the hemostatic effect test result of the rabbit ear artery bleeding model shows that the hemostatic time is <95 seconds.
Embodiment 2
[0035] 12 grams of carboxymethyl chitosan, 10 grams of hyaluronic acid and 1 g of gluconolactone were dissolved in 1 liter of deionized water and kept at 50°C for 10 hours. After the polyelectrolyte complex was dried in a blast dryer at 70° C. for 40 hours, it was ball-milled for 1 hour with a ball mill to obtain carboxymethyl chitosan polyelectrolyte hemostatic powder. The hemostatic powder has good biocompatibility and antibacterial property, and exhibits excellent hemostatic function. The measurement of coagulation index in vitro in this embodiment shows that the coagulation index in vitro is <65%; the hemostatic effect test result of the rabbit ear artery bleeding model shows that the hemostatic time is <112 seconds.
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