12 results about "Nerve conduction velocity" patented technology

The invention relates to the technical field of intelligent medical auxiliary diagnosis and neural function automatic evaluation, in particular to an NIHSS score automatic evaluation system for a stroke patient. Comprising a multi-mode induction and perception unit which is used as a front-end data entry and is used for collecting patient response in real time to generate a video stream containing depth and color information and a synchronous audio stream; the dynamic reference calibration unit is used for extracting kinematic characteristics to construct an individualized nerve reference template; the neural motion spectrum decomposition unit is used for generating a spectrum pathological feature vector for distinguishing myasthenia and ataxia; the opposite-side image rejection analysis unit is used for generating compensation and driving confidence for representing a real nerve driving intention; the cross-modal reflection analysis unit is used for generating a sensory pathway integrity index according to the nerve conduction velocity difference; and the collaborative scoring decision engine is used for mapping the multi-modal features into standardized NIHSS scores. According to the method, the interference of age and basic physique on scoring is effectively eliminated, and a high-precision comparison reference can be provided for subsequent abnormal judgment of the affected side.

The invention discloses an application of fenoterol hydrobromide and pharmaceutically acceptable salt thereof in preparation of a medicine for treating diabetic peripheral neuropathy. The fenoterol hydrobromide and the pharmaceutically acceptable salt thereof have obvious effects of promoting growth of peripheral sensory neurite and protecting myelin sheath injury, and can improve symptoms of slow nerve conduction speed and sensory deficiency induced by diabetes mellitus.

The invention provides an efficient enrichment and purification method of adipose-derived stem cell exosomes. According to the invention, the sex determining gene is used for distinguishing and identifying the adipose-derived mesenchymal stem cells from different sources for the first time, and then the culture medium containing specific sex hormone and regulatory factors is used for realizing in-vitro amplification of the adipose-derived mesenchymal stem cells, so that convenience is provided for preparation of the adipose-derived mesenchymal stem cell exosome. According to different sources of adipose-derived stem cell exosomes, different effects of the adipose-derived stem cell exosomes are respectively verified, and the male adipose-derived stem cell exosomes can realize skin injury repair by effectively promoting fibroblast proliferation; the female adipose-derived stem cell exosome can realize nerve injury protection by regulating the nerve conduction velocity and action potential incubation period of an injured part.

The present application relates to a kind of myelin repair auxiliary method based on neural signal modeling.The method obtains the multi-modal neural signal data such as electroencephalogram signal of individual to be rehabilitated and is preprocessed, forms preprocessed data set;Subsequently, individualized time series modeling process is executed, and the time series characteristic representation including nerve conduction velocity recovery rate, phase consistency and neural pathway integrity is generated, and individualized calibration is carried out by dynamic baseline updating mechanism.The calibrated feature representation is input to the pre-trained deep learning inference engine.The inference engine outputs myelin repair index and imbalance risk score, which is used to represent the degree of repair and predict future abnormal risk.Based on the above index, a set of intervention parameters is generated, including electrical stimulation intervention parameters, virtual rehabilitation training task difficulty and rehabilitation training rhythm, and further forming control instructions to configure virtual rehabilitation training environment and electrical stimulation execution interface, so as to realize the individualized assistance and dynamic optimization of myelin regeneration repair.

The application relates to the technical field of intelligent medical auxiliary diagnosis and automatic evaluation of nerve functions, in particular to an NIHSS score automatic evaluation system for stroke patients. The system comprises a multi-modal induction and perception unit, which is used as a front-end data inlet and collects patient responses in real time to generate a video stream containing depth and color information and a synchronous audio stream; a dynamic reference calibration unit, which extracts kinematic characteristics to construct an individualized neural reference template; a neural motion frequency spectrum decomposition unit, which generates a frequency spectrum pathological characteristic vector distinguishing muscle weakness and ataxia; a contralateral mirror inhibition analysis unit, which generates compensation and driving confidence representing real neural driving intentions; a cross-modal reflection analysis unit, which generates a sensory pathway integrity index according to the difference in nerve conduction velocity; and a collaborative scoring decision engine, which maps multi-modal characteristics to a standardized NIHSS score. The application effectively eliminates the interference of age and basic physical fitness on the score, and can also provide high-precision comparison references for subsequent abnormality determination of the affected side.

The invention discloses a binocular modulation difference-based visual stabilization method, and particularly relates to the technical field of biomedical engineering, and the method comprises the following steps: S1, binocular neural signal conduction delay data acquisition, S2, visual stability adaptive time difference threshold setting, S3, near-infrared light parameter and conduction velocity association relationship establishment, S4, binocular near-infrared light parameter combination screening, and S5, visual stability adaptive time difference threshold setting. And S5, calibrating double-path driving delay parameters. According to the method, a time difference threshold interval is set in combination with a visual phase difference physiological adaptation range, the incidence relation between the near-infrared light parameters and the nerve conduction velocity is established, parameter setting is deeply fused through binocular nerve conduction delay data and cortical neuron response time sequence data, the adaptability of the parameters and the nerve physiological state is enhanced, and the accuracy of the nerve physiological state is improved. The collaborative accuracy of near-infrared light modulation parameters of the two eyes is improved, it is ensured that the time sequence of the two-way driving signals is accurately matched with a nerve regulation target needed by visual stability, and the problem that the visual regulation effect is poor due to parameter setting deviation is solved.

The application relates to the technical field of compound medicines, and discloses application of a compound external-use patch for preventing and treating diabetic peripheral neuropathy, wherein the compound external-use patch comprises a gel base and dry extract and volatile oil doped into the gel base, the dry extract and the volatile oil are derived from a compound, and the compound is composed of 10-20 parts of cinnamon, 8-12 parts of asarum, 8-12 parts of evodia, 8-12 parts of chuanxiong and 0.2-0.8 parts of borneol in terms of weight parts. The compound external-use patch of the application is locally pasted on acupoints or joints of DPN rats, can reduce the blood sugar level of diabetic peripheral neuropathy rats, increase the insulin level, improve insulin resistance, prolong the latent period of hot stimulation foot withdrawal, increase the nerve conduction velocity, maintain the normal morphology and function of nerve cells, and therefore can prevent and inhibit the generation and deterioration of diabetic peripheral neuropathy; and the compound external-use patch improves the safety and convenience of patients in taking medicine compared with oral medicine.

The invention relates to a myelin sheath repair auxiliary method based on neural signal modeling. According to the method, multi-modal neural signal data such as electroencephalogram signals of a to-be-recovered individual are obtained and preprocessed, and a preprocessed data set is formed; then, an individualized time sequence modeling process is executed, time sequence feature representation containing indexes such as the nerve conduction speed recovery rate, the phase consistency and the neural pathway integrity is generated, and individualized calibration is carried out through a dynamic baseline updating mechanism. The calibrated feature representation is input to a pre-trained deep learning inference engine. The inference engine outputs a myelin sheath repair index and an imbalance risk score for representing a repair degree and predicting a future abnormal risk. An intervention parameter set is generated based on the indexes, the intervention parameter set comprises electrical stimulation intervention parameters, virtual rehabilitation training task difficulty and rehabilitation training rhythms, and a control instruction is further formed to configure a virtual rehabilitation training environment and an electrical stimulation execution interface, so that personalized assistance and dynamic optimization of myelin sheath regeneration and repair are realized.

The application provides an application of 3-(methylsulfonyl) propionitrile in preparation of a medicine for treating peripheral nerve adhesion diseases, relates to the field of biomedical technology, and is verified through a sciatic nerve adhesion mouse model that 3-(methylsulfonyl) propionitrile can effectively reduce the adhesion degree of nerves and peripheral tissues, and can significantly improve muscle atrophy symptoms; compared with the traumatic and high recurrence rate of surgical treatment, the drug is a non-invasive or minimally invasive treatment, has good patient tolerance, can effectively reduce treatment risks and rehabilitation costs, and has wider clinical applicability. Secondly, the drug plays a treatment effect through a double action mechanism: on the one hand, adhesion formation is inhibited, and nerve compression is released; on the other hand, nerve myelin sheath regeneration can be promoted, myelin sheath structure integrity is improved, nerve conduction velocity is improved, and the synergistic effect of 'adhesion release + nerve repair' is realized. Animal experiments prove that the drug can significantly improve the motion balance ability and gait function of model mice.

The invention provides a balancing stand detection method and device combined with myoelectricity sensing, and the method comprises the steps: applying platform disturbance in a preset direction, and synchronously collecting a myoelectricity signal and a platform motion parameter of a target muscle group of a user; and extracting the response duration and the muscle amplitude index of the electromyographic signal, and generating muscle group response characteristics. And outputting a neuromuscular function evaluation result based on the mapping relationship between the direction of the disturbance applied by the platform and the muscle group response characteristics. Wherein the response characteristics comprise that the reaction duration is used for quantifying the nerve conduction velocity. The muscle amplitude is used for quantifying the muscle power intensity. The bilateral muscle group response difference of the target muscle group is used to identify the collaborative imbalance. Whether the user muscle group is in an unbalanced state or not is detected through the method.

The invention relates to the technical field of auxiliary diagnosis, in particular to a children twitch disorder auxiliary diagnosis method, which comprises the following steps of: shooting a video of 1-5 minutes for a doctor seeing child, the frame number of the video being greater than or equal to 67 frames; acquiring head information of a doctor seeing child through the video; establishing a time axis for the video; performing blink identification, mouth opening identification and head shaking identification on the head information; judging whether a mouth is opened within 15-35ms after each blink on the time axis, if so, judging whether head shaking exists within 30-75ms after the first node, and if so, recording as complete twitch; according to the method, the eyes, the mouth and the head are independently identified by adopting an algorithm, and the complete twitch is defined in cooperation with the time axis and the nerve conduction velocity, so that normal blinking, normal mouth opening and normal head shaking can be prevented from being listed as abnormal conditions, the diagnosis efficiency is improved, and the diagnosis objectivity and accuracy are enhanced.

A compound represented by formula (I) and a preparation method thereof, and a pharmaceutically acceptable salt thereof, a metabolic precursor thereof, a metabolite thereof, an isomer thereof or a prodrug thereof; experiments show that the indole alkaloid not only promotes axon growth of peripheral sensory neurons, improves the nerve conduction velocity and anesthesia symptom of diabetic rats, but also promotes healing of foot ulcer wounds of diabetic rats, thus having good therapeutic effects on diabetic complication peripheral neuropathy and diabetic feet; they also show that the indole alkaloid also obviously reduces a degree of pulmonary fibrosis induced by bleomycin in mice, and plays a role in protecting lung tissues.