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Medicinal composition for treating diabetic peripheral neuropathy, and preparation method thereof

A technology for peripheral neuropathy and composition, which is applied in drug combinations, nervous system diseases, and pharmaceutical formulations. Improvement of conduction velocity and peripheral microcirculation, definite curative effect

Active Publication Date: 2013-08-21
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation methods of the above applications (patents) mostly adopt conventional water extraction, or directly pulverize and prepare. Most of the prescriptions are based on promoting blood circulation and removing blood stasis. The disadvantages are that the process is rough and the effective parts are not clear. The efficacy and quality of the drug cannot be guaranteed

Method used

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  • Medicinal composition for treating diabetic peripheral neuropathy, and preparation method thereof
  • Medicinal composition for treating diabetic peripheral neuropathy, and preparation method thereof
  • Medicinal composition for treating diabetic peripheral neuropathy, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The raw materials were weighed according to the following proportions: 9 parts of astragalus, 6 parts of Ligustrum lucidum, 6 parts of cassia twig, 6 parts of red peony, 6 parts of scutellaria baicalensis, 6 parts of coptis, 2 parts of leech, 6 parts of corydalis, and 6 parts of Caulis Spatholobus.

[0060] Preparation method: Take astragalus, Ligustrum lucidum, Guizhi, red peony, and Caulis Spatholobus according to the formula, add 8 times the amount of water, decoct twice for 2 hours each time, combine the decoctions, and concentrate to a relative density of 1.05~ 1.10 (50°C), add ethanol to make the ethanol concentration reach 70%, filter, recover the filtrate, and dry under reduced pressure to obtain the water extract extract; take the medicinal materials of Scutellaria baicalensis, Coptidis Rhizome, leech, and Corydalis (made from vinegar), Add 6 times the amount of 70% ethanol solution, reflux extraction for 3 times, each time for 1h, combine the alcohol extracts, ...

Embodiment 2

[0063] The raw materials were weighed according to the following proportions: 48 parts of astragalus, 24 parts of Ligustrum lucidum, 24 parts of cassia twig, 24 parts of red peony, 24 parts of scutellaria, 24 parts of berberine, 18 parts of leech, 24 parts of corydalis, and 24 parts of Caulis Spatholobus.

[0064] Preparation method: Take astragalus, Ligustrum lucidum, Guizhi, red peony, and Caulis Spatholobus medicinal materials according to the formula, add 12 times the amount of water, decoct 3 times, each time for 2 hours, combine the decoction, concentrate to a relative density of 1.05~ 1.10 (50°C), add ethanol to make the ethanol concentration reach 75%, filter, recover the filtrate, and dry under reduced pressure to obtain the water extract extract; take the medicinal materials of Scutellaria baicalensis, Coptidis Rhizome, leech, and Corydalis (made from vinegar), Add 7 times the amount of 70% ethanol solution, reflux and extract 3 times, each time for 1h, combine the al...

Embodiment 3

[0067] The raw materials were weighed according to the following proportions: 30 parts of astragalus, 15 parts of Ligustrum lucidum, 10 parts of cassia twig, 10 parts of red peony, 10 parts of scutellaria baicalensis, 10 parts of coptis, 6 parts of leech, 10 parts of corydalis, and 10 parts of Caulis Spatholobus.

[0068] Preparation method: Measure Astragalus, Ligustrum lucidum, Guizhi, Radix Paeoniae Rubra, and Caulis Spatholobus according to the formula, add 10 times the amount of water, decoct 3 times for 2 hours each time, combine decoctions with water, and concentrate to a relative density of 1.05~ 1.10 (50°C), add ethanol to make the ethanol concentration reach 70%, filter, recover the filtrate, and dry under reduced pressure to obtain the water extract extract; take the medicinal materials of Scutellaria baicalensis, Coptidis Rhizome, leech, and Corydalis (made from vinegar), Add 6 times the amount of 70% ethanol solution, reflux extraction for 3 times, each time for 1h...

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Abstract

The invention relates to a medicinal composition for treating the diabetic peripheral neuropathy, and a preparation method thereof. The medicinal composition is mainly composed of Radix Astragali, Ligustri Lucidi Fructus, cassia twig, Radix Paeoniae Rubra, Radix Scutellariae, Rhizoma Coptidis, leech and the like, and the medicinal composition can be processed through using pharmaceutically acceptable carriers or excipients to prepare medicaments comprising a capsule, a granule, a tablet, a soft capsule, a pill and the like. The medicinal composition has the qi tonifying, yin nourishing, detoxifying, blood stasis dispersing and vein relaxing efficacies, and can be taken by diabetic peripheral neuropathy patients. Clinic research results show that the medicinal composition can obviously improve limb numbness, limb aches, lime end coldness, abnormal sensation, fatigue, asthenia and the like of the diabetic peripheral neuropathy patients, obviously improves the nerve conduction velocity and the terminal microcirculation, substantially reduces the content of sorbitol in erythrocytes, and has no obviously untoward effects.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition for treating diabetic peripheral neuropathy and a preparation method thereof. 2. Background technology [0002] Diabetic peripheral neuropathy (DPN) is one of the common complications of diabetes, and the clinical incidence rate is relatively high. According to the research on the prevalence of neuropathy in diabetic (DM) population in Rochester, Minnesota, USA, 60% to 80% of diabetic patients have There is one or more forms of neuropathy, which can involve any peripheral nerve and seriously endanger the patient's physical health. Although it is not the main cause of death in DM patients, it is indeed the main factor of disability in DM patients, and it is one of the main causes of chronic refractory ulcers of lower limbs and feet, dry gangrene, wet gangrene and amputation (toes) in diabetic patients. . At present, 50% to 75% of amputations caused by non-traumatic reasons are caused by diabetic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61P3/10A61P25/02
Inventor 刘铜华
Owner BEIJING UNIV OF CHINESE MEDICINE
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