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Diabetic peripheral neuropathy treating traditional Chinese medicine composition and preparation method thereof

A technology for peripheral neuropathy and diabetes, applied in drug combinations, nervous system diseases, pharmaceutical formulations, etc., can solve problems such as increasing adverse drug reactions and easy recurrence

Inactive Publication Date: 2018-09-14
河北中唐医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Regarding the treatment of diabetic peripheral neuropathy, Western medicine generally adopts methods such as controlling blood sugar, repairing nerves, anti-oxidation, and improving microcirculation, and uses a combination of multiple drugs aimed at symptoms, and the combined application of multiple drugs has obvious effects in a short period of time. However, it is easy to relapse, and it also increases the probability of adverse drug reactions. In the end, the patient had to amputate to save his life.

Method used

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  • Diabetic peripheral neuropathy treating traditional Chinese medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Aconite 10g, Guizhi 15g, Astragalus 30g, Ginseng 12g, Salvia miltiorrhiza 15g, Chuanxiong 10g, Angelica 10g, Radix Paeoniae Rubra 8g, Safflower 9g, Ephedra 10g, Asarum 8g, Smilax tuckahoe 16g g, Anemarrhena 12 g, Gastrodia elata 10 g, Haifengteng 14 g, Caterpillar 15 g and Chuan Achyranthes bidentata 13 g.

[0051] The above 17 herbs are sterilized by circulating steam at 100°C for 30 minutes, crushed into fine powder, sieved to 100 mesh, added water according to the ratio of fine powder: water = 1:0.3-0.8, stirred evenly, made into water pills, dried and sorted, namely have to.

Embodiment 2

[0053] Aconite 6 g, Gui Zhi 21 g, Astragalus 12 g, Ginseng 18 g, Salvia miltiorrhiza 6 g, Chuanxiong 18 g, Angelica 6 g, Radix Paeoniae Rubra 12 g, Safflower 6 g, Ephedra 18 g, Asarum 3 g, soil Poria cocos 27 g, Anemarrhena 6 g, Gastrodia elata 18 g, Caulis chinensis 6 g, genus 24 g and Achyranthes bidentata 6 g.

[0054] Mix the above 17 herbs, take 30% of the Chinese herbal medicines, sterilize them by steam at 100°C for 30 minutes, crush them into fine powder, sieve them into 100 mesh for later use, and add the remaining 70% of the Chinese herbal medicines to decoct twice, adding 1193g of water for the first decoction, Decoct for 1 hour, add 895g of water for the second decoction, decoct for 40 minutes, combine the decoction, filter, concentrate the filtrate at 70°C to a clear paste with a relative density of 1.15-1.25 g / cm³, add the above-mentioned 100-mesh fine powder, Mix evenly, make concentrated water pills, dry and arrange, that is to say.

Embodiment 3

[0056] Aconite 18 g, Guizhi 6 g, Astragalus 45 g, Ginseng 6 g, Salvia miltiorrhiza 21 g, Chuanxiong 6 g, Angelica 18 g, Radix Paeoniae Rubra 3 g, Safflower 15 g, Ephedra 6 g, Asarum 12 g, soil Poria 6 g, Anemarrhena 18 g, Gastrodia elata 6 g, Caulis Caulis 24 g, Caterpillar 6 g and Achyranthes bidentata 21 g.

[0057]Take the above-mentioned 17 medicinal materials and add water to decoct twice, add 1896g of water to the first decoction, decoct for 1 hour, add 1422g of water to the second decoction, decoct for 40 minutes, combine the decoction, filter, add ethanol for alcohol precipitation after the filtrate is concentrated, and take Ethanol is recovered from the supernatant, and concentrated at 70°C to a clear paste with a relative density of 1.20-1.25g / cm³. Add lactose or dextrin 2-5 times the weight of the clear cream, mix well, granulate, dry, and obtain.

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Abstract

The invention relates to a diabetic peripheral neuropathy treating traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw material ingredients in parts by weight: 6 to 18 parts of radix aconiti lateralis preparata, 6 to 21 parts of cassia twig, 12 to 45 parts of radix astragali seu hedysari, 6 to 18parts of radix et rhizoma ginseng, 6 to 21 parts of radix salvia miltiorrhizae, 6 to 18 parts of rhizoma chuanxiong, 6 to 18 parts of Chinese angelica root, 3 to 12 parts of radix paeoniae rubra, 6 to 15 parts of safflower, 6 to 18 parts of herba ephedrae, 3 to 12 parts of herba asari, 6 to 27 parts of rhizoma smilacis glabrae, 6 to 18 parts of rhizoma anemarrhenae and 6 to 18 parts of rhizoma gastrodiae. The traditional Chinese medicine composition disclosed by the invention has the advantages of obvious curative effect and small side effects; the diabetic peripheral neuropathy is not proneto relapsing.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating diabetic peripheral neuropathy and a preparation method thereof. Background technique [0002] Peripheral neuropathy is one of the most common chronic complications of diabetic patients. According to statistics, the incidence of diabetic peripheral neuropathy is significantly related to the duration of diabetes. The incidence of diabetes within 1 year is less than 10%. The incidence rate is above 50%, and the incidence rate is as high as 90% in patients with a course of 20 years. Its clinical manifestations are diverse, and the disease process is insidious and gradual. It is one of the main causes of non-traumatic amputation. There are many theories about the pathogenesis of diabetic peripheral neuropathy, but there is no unified conclusion. At present, it is believed that the occurrence of diabetic peripheral ne...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/8988A61P3/10A61P25/02
CPCA61K36/17A61K36/21A61K36/232A61K36/236A61K36/24A61K36/258A61K36/268A61K36/286A61K36/481A61K36/537A61K36/54A61K36/65A61K36/67A61K36/71A61K36/714A61K36/896A61K36/8964A61K36/8988A61K36/90A61K2236/331A61K2236/39A61K2236/51A61P3/10A61P25/02A61K2300/00
Inventor 王钢柱
Owner 河北中唐医药有限公司
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