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Medicine for treating diabetic peripheral neuropathy, preparation method and use thereof

A technology for peripheral neuropathy and diabetes, applied in nervous system diseases, drug combinations, pharmaceutical formulas, etc., can solve the problems of increasing the risk of side effects, increasing the cost of medication, etc., to achieve changes in microcirculation, wide application, and increase conduction velocity Effect

Pending Publication Date: 2019-09-03
ZHENGZHOU UNIV OF IND TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for those with severe pain, in addition to taking the above-mentioned drugs, analgesic treatment is also required, which increases the risk of side effects of medication and the cost of medication for patients will also increase accordingly

Method used

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  • Medicine for treating diabetic peripheral neuropathy, preparation method and use thereof
  • Medicine for treating diabetic peripheral neuropathy, preparation method and use thereof
  • Medicine for treating diabetic peripheral neuropathy, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 is used for the preparation of the medicine of diabetic peripheral neuropathy

[0023] Weigh 10 kg of cassia medicinal material, soak for 24 hours, ethanol concentration 80% (volume fraction), flow rate 3ml / (min·kg), and ethanol consumption 8 times the percolation method to obtain cassia to obtain ethanol extract. The cassia seeds are soaked in 2-8 times the volume of cold water first, and extracted by any method of warm soaking extraction, decoction extraction and reflux extraction to obtain a water extract. All the obtained water extracts and ethanol extracts were combined to obtain a drug for the treatment of DPN.

Embodiment 2

[0024] Embodiment 2 to the treatment of diabetic peripheral neuropathy

[0025] 1 material

[0026] 1.1 Animals 6-week-old male SPF-grade obese type 2 diabetic C57BL / 6ob / ob mice and C57BL / 6 wild-type mice were provided by the Experimental Animal Center of Zhejiang University of Traditional Chinese Medicine. The breeding room is kept well ventilated, the room temperature is controlled at (21±1)°C, the humidity is 63%, the noise is ≦55dB, free to eat and drink, and the time of light and dark alternates every 12h.

[0027] 1.2 Reagents and instruments Han's analgesic instrument (Nanjing Jisheng Medical Technology Co., Ltd., HANS-100 type). The drug used to treat diabetic peripheral neuropathy is extracted from the School of Medicine of Zhengzhou Institute of Technology, and is prepared with distilled water to a concentration of 20mg·mL before gavage －1 suspension; α-lipoic acid capsules, specification: 0.3g per capsule, batch number: 170313, produced by Penglai Nuokang Pharmace...

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Abstract

The invention belongs to the technical field of a traditional Chinese medicine, and particularly relates to a medicine for treating diabetic peripheral neuropathy, a preparation method thereof and usethereof. The medicine for treating diabetic peripheral neuropathy is obtained by combining a mixed extract of a cassia seed water extract and a cassia ethanol extract with an extraction part containing an anthraquinone compound, unsaturated fatty acid, and a naphthoppyrone component. The medicine can improve peripheral nerves by increasing nerve conduction velocity and improving local microcirculation, and thus can play a role in preventing and treating the diabetic peripheral neuropathy.

Description

[0001] 【Technical field】 [0002] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a medicine for treating diabetic peripheral neuropathy, a preparation method and application thereof. [0003] 【Background technique】 [0004] Cassia is the dry mature seed of Cassia obtusi folia L. or Cassia tora L. of the leguminous plant. It is also known as Cassia obtusi foliage, Cassia cassia, and horseshoe. It tastes sweet, bitter, salty, slightly cold, and has the ability to clear away heat. The effect of improving eyesight, moistening the intestines and laxative is mainly used for the treatment of red eyes, astringent pain, embarrassment and tears, headache, dizziness, dark eyes, constipation, etc. Mainly produced in Guangxi, Sichuan, Zhejiang and other places, cassia seed is a medicine with the same origin as medicine and food. A large number of experimental studies have shown that proteins, polysaccharides, benzopyrrolones and ...

Claims

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Application Information

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IPC IPC(8): A61K36/482A61P3/10A61P25/02A23L33/105
CPCA61K36/482A61P3/10A61P25/02A23L33/105A61K2236/331A61K2236/333A23V2002/00A23V2200/328A23V2200/322
Inventor 赵新永孙岩杨占峰刘俊霞邢欢欢贾盼盼王世广
Owner ZHENGZHOU UNIV OF IND TECH
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