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Pharmaceutical composition for treating or preventing nerve damage

A technology for nerve injury and composition, which can be used in the field of medicine to solve problems such as side effects, chronic pain and abnormal nerve reflexes

Active Publication Date: 2019-08-02
GUANGDONG MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, nerve growth factor (NGF) in exogenous neurotrophic factors has the most reliable curative effect, but the application of NGF also has side effects: the sprouting of undamaged normal nerve axons can lead to chronic pain and abnormal nerve reflexes, etc. Adverse reactions occur

Method used

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  • Pharmaceutical composition for treating or preventing nerve damage
  • Pharmaceutical composition for treating or preventing nerve damage
  • Pharmaceutical composition for treating or preventing nerve damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～4

[0029] Examples 1-4 The ingredients and preparation methods of the pharmaceutical composition of the present invention are shown in Table 1.

[0030] Table 1: Embodiment 1~4 pharmaceutical composition composition of the present invention and preparation method

[0031]

[0032]

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating or preventing nerve damage. The pharmaceutical composition comprises the following components: asiaticoside, an Aloe vera extract, a sweetsop seed extract, a leontopodium alpinum extract, and a vascular endothelial growth factor (VEGF). The pharmaceutical composition of the invention is useful for inducing neurite outgrowth, for promoting stem cell function, and / or for promoting functional recovery and enhancing synapse formation and synaptic plasticity in damaged and / or injured neurons in acute and chronic injury, and can significantly alleviate impaired sciatic nerve function, increase nerve conduction velocity, increase axon count, and repair axons. Clinical studies show that the pharmaceutical composition of the inventioncan improve muscle strength, accelerate repair of damaged nerve tissue, and improve nerve tissue transmission and metabolic disorders in patients with peripheral nerve injury.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating or preventing nerve damage. Background technique [0002] Nerve injury is a common neurosurgical disease, clinically manifested in varying degrees of motor and sensory disturbances, as well as autonomic nervous system dysfunction and limb nutritional disorders. Motor dysfunction manifests as weakening or loss of muscle strength innervated by damaged nerves; sensory dysfunction manifests as diminished or disappearing sensation in areas innervated by injured nerves. However, nerve repair is an extremely complicated process. Problems such as scar formation after nerve injury repair, and nerve and surrounding tissue adhesion still seriously affect the recovery of sensory motor function of the affected limb. [0003] The nerve injury drugs currently used clinically include exogenous neurotrophic factors, adenylate cyclooxygenase activators a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61P25/00A61K31/7024A61K36/896A61K36/886
CPCA61K31/7024A61K36/185A61K36/28A61K36/886A61K36/896A61K38/1866A61K2236/333A61P25/00A61K2300/00
Inventor 王涛吴洪福余茂林余纳
Owner GUANGDONG MEDICAL UNIV
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