The invention provides a Chinese herbal medicine compound preparation for treating pullorum disease with an obvious effect. The preparation is prepared from the following raw materials in parts by weight: 15-25 parts of astragalus, 35-45 parts of scutellaria baicalensis, 25-35 parts of golden cypress, 25-35 parts of the root of Chinese pulsatilla, 25-35 parts of fructus forsythiae, 15-25 parts of cape jasmine, 25-35 parts of radix paeoniae alba, 15-25 parts of pericarpium citri reticulatae, 55-65 parts of rhizome atractylodis, 10-20 parts of smoked pulm, 15-25 parts of herba portulacae, 25-35 parts of folium isatidis, 5-15 parts of radix sophorae flacescentis, 15-25 parts of the bark of ash, 25-35 parts of wolfiporia extensa. The preparation is prepared by carrying out superfine grinding on the raw medicinal materials until the particle size is 30-90 microns, weighing in a mixture ratio and uniformly mixing. The Chinese herbal medicine compound preparation provided by the invention has the efficacies of removing heat for detoxication and eliminating dampness for preventing dysentery, and mainly acts on endoretention of damp heat and pullorum disease; a micronization technology is adopted, so that medicine waste is reduced, energy is saved, and environment is protected; and dosage is reduced, and treatment cost is reduced.