Method for preparing functional target disk of mass spectrum sample de-absorbed by ground substance assistant laser
A matrix-assisted laser and sample target technology, applied in the direction of selective adsorption, material separation, instruments, etc., can solve the problems of interference analysis and identification, loss of active sites, cumbersome target disk production process, etc., to achieve rich and uniform pores and easy derivatization , Rich and controllable effects on the outer surface
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example 1-3
[0025] Example 1-3: During the synthesis process of the corresponding nano-zeolite molecular sieve, by adjusting the reactant FeCl 3 The proportion of the solution is added to obtain a series of different ratios of 0.1%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3.0%, 3.5%, 4.0%, and 4.5% in the skeleton structure. The heteroatom nano zeolite crystal material (crystal size is about 250-300nm) of iron metal element, according to the specific technical route described in the invention technical scheme (2)-(6), make the heteroatom nano zeolite crystal material synthesized , uniformly modified on the surface of the MALDI stainless steel sample target disc to prepare a new type of MALDI functional sample target disc whose surface is uniformly decorated with nano-zeolite molecular sieve crystal materials doped with different proportions of iron metal atoms in the skeleton structure. Subsequently, the new MALDI functional sample target plate was used to directly enrich and identify the presence ...
example 4
[0026] Example 4: In the synthesis process of the corresponding nano-zeolite molecular sieve, by adjusting the reactant GaCl 3According to the proportioning addition of the solution, the framework structure is fixedly doped with 0.1%, 0.5%, 1.0%, 1.5%, 2.0%, 2.5%, 3.0%, 3.5%, and 4.0% of a series of heterogeneous gallium elements in different proportions. Atomic nano zeolite crystal material (crystal size is about 250-500nm), according to the specific technical route described in the technical solution of the invention (2)-(6), the framework structure is fixedly doped with different proportions of gallium atoms as active sites The dotted nano-zeolite crystal material was evenly modified on the surface of the MALDI stainless steel sample target plate to prepare the MALDI functional sample target plate, which directly enriched and identified the phosphorylated peptide with a low abundance and a mass number of 2061.062 in the enzymatic hydrolysis mixture of β casein. Relevant exp...
example 5
[0027] Example 5: By adjusting the composition ratio of heteroatom substances such as iron source, titanium source, and gallium source in the corresponding nano-zeolite molecular sieve synthesis reaction mixture, the iron-titanium-gallium-titanium double metal heteroatoms in the framework structure are simultaneously fixed and doped in different proportions as The nano zeolite crystal material of the active site, according to the specific technical route described in the technical scheme (2)-(6) of the invention, the nano zeolite molecular sieve material synthesized above is uniformly modified on the surface of the MALDI stainless steel sample target disk, and the MALDI functional The sample target plate directly enriches and simultaneously identifies the presence of low-abundance phosphorylated peptides with a mass number of 2061.062 in the β-casein hydrolysis mixture, and the existence of low-abundance phosphorylated peptides in the proteolysis mixture of other actual sample s...
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