4 results about "Cherenkov radiation" patented technology

The current disclosure provides systems and methods for increasing a quality of positron emission tomography (PET) images generated by a PET system with detectors including bismuth germinate (BGO) crystals. In one example, a method for the PET system comprises extracting a higher-quality 2-D image from a first image volume reconstructed using higher-quality time-of-flight (TOF) data acquired from a subject during a scan performed using the PET system, the TOF data based on Cherenkov radiation detected at the BGO crystals; extracting a lower-quality 2-D image from a second image volume reconstructed using lower-quality TOF data acquired from the subject by the PET system; generating an enhanced-quality 2-D image from the lower-quality 2-D image using a trained image quality enhancement model; merging the enhanced-quality 2-D image with the higher-quality 2-D image; and displaying the merged 2-D image on a display device of the PET system.

Systems and methods verify position of deformable tissue undergoing radiotherapy using Cherenkov radiation. A Cherenkov image is captured of a treatment area of a subject during the radiotherapy. The Cherenkov image is segmented to generate a bio-morphological feature image defining vasculature of the deformable tissue. A transfer learning strategy is used to train a convolutional neural network to segment the Cherenkov image. A rigid registration of the bio-morphological feature image and a reference image is performed to determine a rigid displacement. A non-rigid registration of the bio-morphological feature image and the reference image is performed to determine a deformation map indicating locoregional deformation of the deformable tissue. A repositioning alert is generated when the locoregional deformation is greater than a deformation threshold, and an abort alert is generated when registration of the bio-morphological feature image and a reference image us unsuccessful.

A multistage depressed collector (MSDC) 200 is disclosed for recovering energy from an electron beam 204 in, for example, an electromagnetic power source generating stimulated Cherenkov radiation. The

This invention provides a radioactive Cherenkov photoactivated intelligent therapeutic nanosensor, its preparation method, and its application, belonging to the field of biomaterials preparation technology. This invention achieves precise matching between the Cherenkov radiation spectrum and the absorption peak of a photosensitizer by constructing an intelligent therapeutic nanosensor, and establishes a dual-response release mechanism in the tumor microenvironment, realizing precise drug release under the synergistic triggering of acidic pH and overexpressed hydrogen sulfide. This invention utilizes the CR self-excitation effect to emit light in normal tissues, while simultaneously quenching fluorescence within the tumor where hydrogen sulfide is overexpressed, thereby achieving dual-locked Cherenkov radiation-mediated photodynamic therapy in the tumor microenvironment. The intelligent therapeutic nanosensor of this invention achieves the transformation from fluorescence emission in normal tissues to tumor-specific activated CR-PDT by forming deep hole trap energy levels, demonstrating excellent practicality.