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Bispecific nano-micelle based on folic acid targeting and Cherenkov radiation response as well as preparation method and application thereof

A nanomicelle, bispecific technology, applied in non-active ingredients medical preparations, active ingredients-containing medical preparations, pharmaceutical formulas, etc., can solve the lack of tumor cell specificity, limit effective delivery, bioavailability Low problems, to reduce non-specific enrichment, enhance specificity, overcome the limited penetration depth

Active Publication Date: 2020-09-25
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Doxorubicin (DOX) is a widely used chemotherapeutic agent for many different types of cancer, but overuse of DOX can cause significant cardiotoxicity
Commonly used chemotherapy drugs such as doxorubicin (DOX), paclitaxel, and cisplatin all have strong hydrophobicity, which limits their effective delivery in vivo and low bioavailability
In addition, due to the lack of specificity for tumor cells, simple intraperitoneal or intravenous injection of chemotherapy drugs will cause strong toxic side effects in the body

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  • Bispecific nano-micelle based on folic acid targeting and Cherenkov radiation response as well as preparation method and application thereof
  • Bispecific nano-micelle based on folic acid targeting and Cherenkov radiation response as well as preparation method and application thereof
  • Bispecific nano-micelle based on folic acid targeting and Cherenkov radiation response as well as preparation method and application thereof

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Embodiment Construction

[0038] In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only It is a part of the embodiments of the present invention, not all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

[0039] It should be noted that the terms "first" and "second" in the specification and claims of the present invention and the above-mentioned drawings are used to distinguish similar objects, and not necessarily used to describe a specific sequence or sequence. It should be understood that the data used in this way can be interchanged under ap...

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Abstract

The invention discloses a bispecific nano-micelle based on folic acid targeting and Cherenkov radiation response as well as a preparation method and application thereof, and belongs to the technical field of nano-material manufacturing and application. According to the invention, a photosensitive group nitrobenzyl is coupled with a hexadecyl DOX derivative (hydrophobicity is enhanced), the coupledproduct is embedded into a folic acid modified amphiphilic polymer (FA-PEG-PCL), the nano micelle NM / DOC is prepared, and the NM / DOC can utilize folic acid to target tumor cells. Furthermore, in theX-ray local radiotherapy process, the X-ray radiation is uniform, the photosensitive group-nitrobenzyl is broken through generated Cerenkov radiation, the hydrophilicity of DOX is improved, drug release is triggered, radiotherapy and chemotherapy are organically integrated, the specificity of chemotherapy drug action is enhanced through active targeting and response drug release of NM / DOC, and thetoxic and side effects on the human body are greatly reduced.

Description

Technical field [0001] The invention belongs to the technical field of nanomaterial manufacturing and application, and specifically relates to a nanomicelle capable of targeting folic acid and releasing chemotherapeutic drugs in response to Cherenkov radiation for synergistic X-ray radiotherapy. Background technique [0002] Currently, radiotherapy and chemotherapy are still the standard treatment strategy for many cancer patients in clinical application, which can achieve effective control of local lesions and prolong the survival time of patients. In addition, simultaneous chemotherapy during radiotherapy has a good prognostic effect on the treatment of advanced rectal cancer, cervical cancer, non-small cell lung cancer, head and neck cancer and other cancers. However, the synergistic treatment of radiotherapy and chemotherapy still has obvious systemic toxicity, which is mainly due to the lack of targeted enrichment ability of general chemotherapy drugs, which is bound to caus...

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Application Information

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IPC IPC(8): A61K9/107A61K31/704A61K47/54A61K47/34A61K47/22A61P35/00
CPCA61K9/1075A61K31/704A61K47/22A61K47/34A61K47/54A61P35/00
Inventor 姚翠萍李炯王斯佳王晶辛静张镇西
Owner XI AN JIAOTONG UNIV
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