The invention discloses a near-
infrared fluorescent probe molecule for
kidney clearance as well as a preparation method and application of the near-
infrared fluorescent probe molecule. The chemical
structural formula of the near-
infrared fluorescent probe molecule is # imgabs0 #, wherein X is S or Se. The molecule adopts a D-pi-A-pi-D structural design, and a
triphenylamine group is used as an
electron donor and a rotor unit, so that a molecular skeleton is obviously distorted, and the molecule is endowed with an aggregation-induced emission (AIE) characteristic. The introduction of the
ethylene glycol fragment can be used for regulating and controlling the hydrophilicity of the probe. The strong
electron acceptor has excellent
electron withdrawing capability, can enhance the intramolecular charge transfer effect, reduces the molecular
band gap, and extends the absorption / emission
wavelength to a near-infrared region. The
kidney clearance near-infrared fluorescent probe molecule provided by the invention has
kidney clearance capability, is simple and convenient in synthesis
route, low in cost and excellent in
biocompatibility, and is suitable for realizing early diagnosis of
acute kidney injury caused by various causes through near-infrared two-region
fluorescence imaging.