Compact microbeam radiation therapy systems and methods for cancer treatment and research

A technology of plane beam and fan beam, applied in the field of radiotherapy system, can solve the problem of limiting the maximum X-ray flux of X-ray tube

Active Publication Date: 2010-12-29
THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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Problems solved by technology

The thermal load on the anode limits the maximum X-ray flux of the X-ray tube

Method used

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  • Compact microbeam radiation therapy systems and methods for cancer treatment and research
  • Compact microbeam radiation therapy systems and methods for cancer treatment and research
  • Compact microbeam radiation therapy systems and methods for cancer treatment and research

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Embodiment Construction

[0026] Conventional X-ray sources generate X-ray radiation from a small area on the X-ray anode ("focal spot") that receives electrons. Local temperatures on the anode can reach over 1500°C when it is bombarded by energetic electrons. The maximum X-ray dose can be limited by the thermal load that the anode can withstand, which is also related to the size of the focal spot. For example, a clinical linear accelerator (LINAC) can only deliver a dose of about 5 Gy / min. In contrast, the present subject matter provides compact, non-synchronous radiation source MRT devices, systems and methods capable of delivering radiation at relatively high dose rates using multiple discrete, narrow x-ray planes or beams. For example, MRT devices, systems, and methods can be used to treat cancer and intraoperative radiation therapy for people with brain tumors. It is also envisioned that the MRT devices, systems and methods disclosed herein may be used as animal models for cancer research.

[0...

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Abstract

The present subject matter relates to compact, non-synchrotron microbeam radiation therapy (MRT) systems and methods for cancer research and treatment based on a carbon nanotube distributed x-ray source array technology. The systems and methods can deliver microscopically discrete x-ray radiation at peak dose rate of 10 Gy per second or higher. The x-ray radiation can be provided by a spatially distributed x-ray source array. The technology can be used, for example and without limitation, for human cancer treatment, for intra-operative radiation therapy, and for pre-clinical cancer research on animal cancer models.

Description

[0001] related application [0002] The presently disclosed subject matter claims priority from 61 / 205,240, filed January 16, 2009, the disclosure of which is hereby incorporated by reference in its entirety. [0003] government interest [0004] The subject matter of the present disclosure was made with US Government funding under contracts U54CA119343 and 1R21CA118351-01 awarded by the National Cancer Center. Accordingly, the United States Government has certain rights in the subject matter of the present disclosure. technical field [0005] The subject matter disclosed herein relates generally to radiation therapy systems and methods. More particularly, the subject matter disclosed herein relates to microbeam radiation therapy systems and methods for cancer treatment and research. Microbeam radiotherapy (MRT) radiation can be characterized by its microscopic discrete spatial radiation distribution (beam width less than 1 mm and beam spacing of several mm) and ultra-high ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10
CPCA61N5/1042A61N5/1069A61B6/508A61N5/10
Inventor O·Z.·周S·X.·常
Owner THE UNIV OF NORTH CAROLINA AT CHAPEL HILL
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