74 results about "Tumour site" patented technology

The invention belongs to the field of bladder cancer treatment, and particularly relates to a drug delivery system based on combination of a biodegradable magnesium alloy stent and a double-J tube. The system comprises a biodegradable magnesium alloy stent and a double-J tube, the surface of the biodegradable magnesium alloy stent is modified by a calcium phosphate coating to form a fine needle-shaped micro-nano structure, and the biodegradable magnesium alloy stent loads an anti-cancer drug oridonin. The biodegradable magnesium alloy stent loaded with oridonin is accurately attached to a tumor part by means of ultrasonic guidance, and the double-J tube and the biodegradable magnesium alloy stent are combined for use. According to the invention, the loading efficiency of the hydrophobic drug is improved through the modification of the micro-nano structure of the calcium phosphate coating, and the anti-tumor effect of the magnesium degradation product is cooperated, so that the problems of high frequency, high toxicity and poor compliance of traditional bladder cancer perfusion treatment and difficulty in delivery of Ori and other natural drugs are solved, and finally, accurate, long-acting and low-toxicity treatment of bladder cancer is realized.

The invention belongs to the technical fields of medical chemistry, new materials and nanotechnology, and relates to a novel diagnosis and treatment agent in the field of interdisciplinary, in particular to a preparation method of a reduction response activation < 19 > F magnetic resonance signal amplification self-degradation nanometer diagnosis and treatment micelle. Poly (benzyl carbamate) is obtained through condensation polymerization as a basic structure, then chemical modification is performed to obtain a self-degradable fluorine-containing amphiphilic block polymer, hydrophobic drug chlorin (Ce6) is loaded through self-assembly, the self-degradable fluorine-containing amphiphilic block polymer has the characteristic of responding to degradation of glutathione (GSH) at a tumor site, and on the basis of maintaining self-degradation of a hydrophobic chain segment of the nano-micelle, the self-degradable fluorine-containing amphiphilic block polymer can be used for preparing the self-degradable fluorine-containing amphiphilic block polymer. The nano-micelle loaded with Ce6 has the advantages that the nano-micelle loaded with Ce6 is used as a carrier, the characteristic of efficient 19F MR imaging is additionally endowed, under laser irradiation, the nano-micelle loaded with Ce6 can enhance a new scheme of breast cancer photodynamic therapy, the effects of responding to tumor microenvironment self-degradation drug release and 19F MRI signal amplification are achieved, and therefore diagnosis and treatment integration of breast cancer is achieved.

The application discloses a low-oxygen and pH dual-response nano-carrier, a drug-loaded nanoparticle and application thereof, and belongs to the technical field of biological medicines. The nano-carrier with moderate particle size and low-oxygen and pH dual-response is obtained by using the reaction of aldehyde benzoic acid, nonaethylene glycol and azo-p-phenetidine, the nano-carrier is specifically targeted to a tumor site, and then specifically releases drugs, thereby reducing toxic side effects; meanwhile, after the nano-carrier responds, benzaldehyde groups are released, the benzaldehyde groups are covalently connected with proteins on a lysosome membrane, the structure and activity of the proteins are changed, the lysosome membrane is broken after the proteins are denatured, the permeability of the lysosome membrane is increased, the nano-carrier cannot be discharged to the extracellular, the drug concentration in cells is greatly improved, and the drug bioavailability of the nano-carrier is significantly improved; in addition, the drug loading capacity of the nano-carrier is high, and therefore, the nano-carrier has a good application prospect.

The invention relates to a cell membrane bionic drug-loaded carbon dot nano-material as well as a preparation method and application thereof. The nano-composite is prepared by the following steps: preparing carbon dots, cross-linking to form a reduction responsive carbon dot nano-cluster, sequentially loading chemotherapeutic drugs and coating a cancer cell membrane to form a nano-vaccine. After the nano vaccine is injected into the body of a mouse through caudal vein, the enrichment of the nano vaccine in a tumor part can be enhanced by utilizing the active tumor targeting characteristic of a cancer cell membrane, and tumor cells can be induced to generate immunogenic death through carried chemotherapy drugs and photothermal therapy, so that chemotherapy / photothermal / immune combined therapy on tumors is realized; the obvious anti-tumor effect is realized. In addition, as a nano vaccine, after subcutaneous injection, the nano vaccine can also utilize the tumor antigen carried by a cancer cell membrane and the adjuvant characteristics of the carbon dots to activate the anti-tumor immunity of an organism so as to prevent tumors, and has potential clinical application value.

This invention is related to the fields of medical biotechnology, nanobiotechnology, and nanomedicine. It involves a nanomedicine product that can release HOC1 (hypochlorous acid) at the tumor site in a controlled manner to treat lung cancer. HOC1 is a potent antimicrobial and antitumor agent that can target tumor tissues while minimizing damage to healthy tissues. The produced nanoparticles have a two-layer structure: the inner layer contains alginate, PFP (perfluoropentane), and Ca(OCl)2 to release HOC1, and the outer layer has a chitosan coating with folate and salicylic acid for targeting and proton release. The production process involves nanoemulsion and coating with the ionic gelation technique. When the nanoparticles are delivered to the lungs and targeted to cancer cells with folate, ultrasound radiation triggers the release of HOC1 to induce apoptosis and destroy cancer cells effectively, reducing side effects and improving treatment outcomes for lung cancer patients.

The application discloses a naphthalene phthalocyanine copper liposome and a construction method and application thereof, and belongs to the technical field of liposome preparations. The naphthalene phthalocyanine copper liposome can improve the problems of poor water solubility and insufficient stability of existing sonosensitizers by wrapping naphthalene phthalocyanine copper and catalase in the liposome. Meanwhile, the naphthalene phthalocyanine copper liposome has the function of catalyzing the production of O2 by excessive H2O2 in the microenvironment of brain glioma to supply the continuous production of ROS in the sonodynamic therapy (SDT), enhances the sonodynamic performance, improves the treatment effect of brain glioma, has the advantages of good biological safety, low immunogenicity and long circulation in the body, can effectively penetrate the blood-brain barrier and be delivered to the tumor site, solves the problems that drugs are difficult to penetrate the blood-brain barrier and cannot reach an effective concentration in the traditional treatment method of brain glioma, and provides a new strategy for the treatment of brain glioma.

The invention belongs to the technical field of biological medicine preparation, and discloses a carrier-free self-assembled nano-drug responding to a tumor microenvironment as well as a preparation method and application of the carrier-free self-assembled nano-drug. According to the present invention, self-assembly is performed based on ENBS-C6, DOX and DSPE-MPEG2000, such that the nanoparticle ENBS / DOX NPs is constructed, and the nanoparticle ENBS / DOX NPs is used for preparing the tumor chemotherapy-photodynamic combined treatment drug; due to enhanced permeability and retention, the drug can be self-delivered to a tumor site without a carrier. And in an acidic tumor microenvironment, interaction of multiple supermolecules is destroyed, and release of free ENBS and DOX is accelerated. Moreover, after in-vitro chemotherapy and photodynamic combined treatment, the growth of tumor cells is almost completely inhibited. Due to no carrier, near-infrared imaging and effective treatment effect, the nano-drug provided by the invention can provide a promising strategy for combined treatment of cancers.

The application relates to the field of nanobiomedicine, and particularly relates to an engineered vesicle and a preparation method and application thereof. The engineered vesicle comprises a nano-vesicle and a calcium phosphate mineralized film coated on the surface of the nano-vesicle, and the nano-vesicle contains p53 protein. The p53 protein contained in the engineered vesicle promotes tumor aging to inhibit proliferation and metastasis, and the aged tumor cells can enhance the immune response against tumors at the tumor site, and the outer calcium phosphate mineralized film coating enables the nano-vesicle particles to effectively reduce the risk of severe inflammation in the body, to be gathered at the tumor site by the EPR effect, and under the acidic tumor microenvironment, the pH-sensitive calcium phosphate mineralized film is broken to expose the vesicle with certain immune stimulating capacity, which synergistically activates the immune response against tumors. The engineered vesicle has wide application prospects, and also lays a foundation for the design and development of a corresponding drug delivery system.

The invention discloses a compound targeting AT1R, which is composed of a target head molecule targeting AT1R, a PEG linker, an aspartic acid linker and a chelating agent, and can be used as a component of a PET tracer agent targeting AT1R. A target head molecule can be embedded into a hydrophobic'pocket 'of AT1R protein, so that high-affinity and high-selectivity targeted binding is realized; the PEG connexon can prolong the residence time of the PET tracer agent targeting the AT1R at the tumor part; different numbers of aspartic acids can regulate and control the pharmacokinetic properties of the PET tracer agent targeting the AT1R, reduce the liver and gall and intestinal signal backgrounds of the PET tracer agent targeting the AT1R, and improve the target-to-cost ratio. Therefore, accurate diagnosis and treatment of digestive system diseases such as digestive tract tumor and liver cancer can be realized. The invention further discloses a PET tracer agent targeting AT1R as well as a preparation method and application of the PET tracer agent.

The present invention discloses a method for improving the solid tumor enrichment ability of red blood cell carriers, specifically: a small molecule compound RRx-001 is loaded into the red blood cell carrier, RRx-001 causes the PS molecules on the surface of the red blood cells to be everted, which can mediate the targeted adhesion of red blood cells to tumor vascular endothelial cells expressing PSR protein, thereby achieving active targeting of tumors. In addition, the present invention transforms red blood cells by RRx-001, thereby enhancing the ability of red blood cells to produce NO, dilates tumor blood vessels by NO, and increases blood flow in tumor blood vessels. The present invention transforms red blood cells by RRx-001 so that they have the performance of both tumor targeting and generating NO to dilate tumor blood vessels, thereby achieving effective enrichment of chemotherapy drugs at the tumor site, and is applicable to all solid tumors, so the present invention is of great significance for drug delivery to tumors.

The invention relates to an ultrasonic response type copper molybdate nano material as well as a preparation method and application thereof. The chemical formula of the nano material is HCu1. 5MoO5. The preparation method comprises the following steps: mixing a molybdenum source, urea and a copper source in water, cooling, crystallizing, and carrying out ultrasonic treatment. Compared with the prior art, the nano material can synchronously generate active oxygen and controllably release copper ions at a tumor site under the accurate control of exogenous ultrasound, and efficiently subvert the copper steady state in tumor cells through the biaxial synergistic effect of'efflux inhibition 'and'internal supply enhancement', so that copper death is specifically induced, and the tumor cell apoptosis is inhibited. And anti-tumor immune response is synergistically activated, so that effective application in treatment of bladder cancer by inducing copper death, especially in treatment of malignant solid tumors such as bladder cancer and pancreatic cancer, is realized.

The application discloses a sequential anti-tumor strategy based on improvement of tumor microenvironment (TME) combined with CAR T and application thereof, and belongs to the technical field of biological medicine, which simultaneously improves tumor fibrosis and acid microenvironment by applying tumor-related fibroblast (CAF) targeting drugs and proton pump inhibitors, and sequentially injects CAR T combined therapy for solid tumors, wherein the CAF targeting drugs are selected from tretinoin, calcipotriol, losartan and minnelide, the proton pump inhibitors are selected from lansoprazole, omeprazole, pantoprazole, rabeprazole and esomeprazole, and the CAR T receptor or ligand is selected from mesothelin, protein tyrosine kinase 7, NKG2D, CD47, B7-H3, MUC1 and HER2; the sequential administration strategy first destroys the dense physical barrier of the tumor microenvironment, improves the acidity of the tumor site, ensures the infiltration, survival and proliferation of CAR T at the tumor site, and then targets and inhibits the growth of solid tumors, especially high-malignancy triple-negative breast cancer, by using the specificity of CAR T.

The invention relates to the technical field of biological medicine, in particular to a cyclic peptide conjugate and application thereof. The invention provides a cyclic peptide conjugate targeting fibroblast activating protein and application of the cyclic peptide conjugate. The cyclopeptide conjugate not only improves the uptake value of the fibroblast activated protein targeting compound at the tumor site, but also reduces the uptake value at the kidney site.

The present disclosure provides a nanocomposite and a preparation method and use thereof. In the present disclosure, the nanocomposite is wrapped with Prussian blue nanoparticles (PB) using a platelet membrane (PM) as a shell; and a surface of the PM is modified with an aptamer of cancer cells and horseradish peroxidase (HRP). An ability of platelets (PLTs) to specifically target cancer cells and inflammatory sites can effectively enhance the accumulation of nanoparticles at tumor sites, and help PB better achieve a desirable photothermal therapy (PTT) under near-infrared light irradiation. In addition, hydrogen peroxide is highly expressed in the tumor microenvironment; the HRP modified on a surface of the nanocomposite can decompose the hydrogen peroxide to generate oxygen bubbles, which drive active transport of the nanocomposite, thereby enhancing the accumulation in cancer cells. Modification with the aptamer of cancer cells on a platelet membrane surface enhances cancer cell targeting.

A method for treating a tumor excise site defined by a center and edges is described. The method includes simultaneously exposing the tumor site to radiation containing fluid and pulsating thermally treated fluid, wherein the fluids are separate from each other and confined to a balloon. Also disclosed is a device for treating a tumor excise site defined by a center and edges. The device includes a reversibly deformable container positioned at the center, the container encapsulating thermally treated fluid; a first drainage conduit; and a second radio-isotope containing conduit contacting a second longitudinally extending surface of the first drainage conduit so as to be positioned between the first drainage conduit and the center.

The invention discloses a polypeptide ligand targeting fibroblast activating protein and application of the polypeptide ligand. Part of the structure in the cyclopeptide skeleton of the ligand is a peptide mimetic skeleton structure aiming at an FAP target, the specific binding force with the FAP is stronger, the ligand has stronger FAP targeting, higher tumor specificity and faster kidney clearance rate, and the retention time at a tumor part is longer, so that the ligand has an obvious inhibiting effect on the FAP and can be used as or used for preparing an FAP inhibitor; the compound can be connected with one of a fluorophore, a radionuclide for diagnosis, a chelating group containing the radionuclide for diagnosis and the like to serve as or be used for preparing a developing agent for developing tumors, inflammatory sites, infected sites and the like. The polypeptide can be connected with one of therapeutic radionuclide, a chelating group containing the therapeutic radionuclide, a cytotoxin group, other functional groups and the like to serve as or be used for preparing targeted polypeptide coupling drugs for treating diseases such as tumors, inflammations, infection and the like; the effect is good, the safety is high and the application is wide.

The present application relates to the technical field of targeting carrier, in particular to a kind of magnetic nanoparticle targeting carrier for liver cancer and its use method, comprising: the superparamagnetic magnetite magnetic inner core with, the inner core is surface modified, and modification group is carboxyl;Platelet membrane layer that is tightly wrapped the inner core, and the platelet membrane layer is derived from the platelet of healthy individual;Gal and anti-PD-L1 antibody modified on the surface of the platelet membrane layer;Chemotherapeutic drug is loaded in the inner core, and the platelet membrane layer is combined with inner core by ultrasound fusion;The magnetic nanoparticle targeting carrier of the present application has significant therapeutic effect in the treatment of liver cancer, and the superparamagnetic magnetite magnetic inner core in the technical scheme of the present application not only provides magnetism for carrier, so that it can be guided to move directionally under external magnetic field, and accurately gather in tumor site, improve the concentration of drug in tumor tissue.

Based on chloroauric acid and a cobalt precursor, through the synergistic effect of a stabilizer and a chiral ligand, the chiral gold-cobalt nano particle with the multi-layer structure is successfully constructed. The nanoparticles show excellent physical and chemical characteristics under the selection of metal elements and the regulation and control of ligands. Through the synergistic effect of gold and cobalt, the magnetism of the material is enhanced, the material is endowed with unique optical characteristics, and meanwhile, the material has special biocompatibility and stability due to introduction of a chiral ligand. Particularly, in treatment of oral squamous cell carcinoma, by virtue of excellent magnetic and optical properties, the magnetic nano-material can effectively target a tumor site and improve the treatment effect, and a novel, efficient and safe treatment strategy is provided for treatment of oral squamous cell carcinoma. The novel chiral gold-cobalt nanoparticles are expected to play an important role in the field of cancer treatment, especially in targeted therapy and imaging diagnosis.

A nanobowl-supported drug-loaded liposome, a preparation method therefor, and an application thereof. The preparation method for the nanobowl-supported drug-loaded liposome comprises: incubating and ultrasonically treating a nanobowl and a liposome and then successfully encapsulating a drug by utilizing an ammonium sulfate active drug loading method to obtain the nanobowl-supported drug-loaded liposome. The nanobowl-supported drug-loaded liposome can resist the influence of plasma proteins and blood flow shearing forces on drug leakage, enhance the delivery of the drug at a tumor site, improve carrier stability, and improve an anti-tumor curative effect.

The invention provides a polypeptide as well as a conjugate and application thereof. Wherein the polypeptide has an amino acid sequence as shown in SEQ ID NO: 1, and the amino acid represented by X at the 14th site and / or the 39th site has the following characteristics: the amino acid can be coupled with a modifier, and can be uncoupled with the modifier in a tumor microenvironment to release the polypeptide; wherein the binding capacity of the polypeptide which is not coupled with the modifier and the CD122 is marked as the first binding capacity, the binding capacity of the polypeptide which is coupled with the modifier and the CD122 is marked as the second binding capacity, the ratio of the first binding capacity to the second binding capacity is marked as n, and n is larger than or equal to 5. Under the action of a tumor specific enzyme, the polypeptide is prevented from activating NK cells and CD8 + T cells in peripheral circulation due to shielding of the modifier, and under the action of the tumor specific enzyme, the polypeptide is uncoupled from the conjugate and recovers activation of an IL2-R beta gamma receptor, so that a specific killing effect is achieved at a tumor part.

The present application belongs to the technical field of nanometer material preparation, and relates to a kind of nanometer medicine, including medicine carrier and active ingredient, medicine carrier adopts amphiphilic polymer, and active ingredient includes photosensitizer Ce6 and analgesic drug LC. The preparation method of the nanometer medicine is also disclosed, comprising the following steps: weighing Ce6, analgesic drug LC and amphiphilic polymer, dissolving in solvent to obtain a mixed solution; the mixed solution is stirred uniformly, and dialyzed in ultrapure water; the solution obtained by dialysis is constant volume, and filtered to obtain nanometer medicine. The nanometer medicine particle size morphology is regular, the particle size is uniform, has good stability within 7 days, can have good enrichment effect at tumor site, and has good photodynamic therapy effect. Lidocaine and photosensitizer reach the lesion site at the same time through intravenous injection, not only reduce the operation steps, but also target the lesion site, reduce the anxiety of patients because they feel that anesthesia will affect intelligence.

The application discloses a kind of cannabidiol heat-sensitive nano hydrogel preparation and its injection and its preparation method, the injection includes cannabidiol 5-15mg / mL, Poly (I:C) 0.5-1.5mg / mL and Pluronic F127 concentration is 20-30wt%.The injection can slow-release cannabidiol and Poly (I:C) and prolong its residence time at tumor site, reduce dosing frequency, effectively and continuously synergistic inhibition tumor, reduce side effects.

A suspension comprising radioactive microspheres. The radioactive microsphere comprises a resin microsphere and a radionuclide loaded on the resin microsphere, wherein the average particle size of the radioactive microsphere is 25 μm to 40 μm. By means of controlling the proportion of non-spherical microspheres in the radioactive microspheres to be within 5%, the distribution density of the microspheres at a tumor part is increased, the effect of killing tumors is improved, and the treatment safety is improved.

A driving assembly is movably connected to the interior of a scalpel cylinder, an ejection assembly is arranged at one end of the driving assembly and connected with the driving assembly in a buckled mode, and a protection assembly is further arranged at one end of the scalpel cylinder and drives the driving assembly to move in the scalpel cylinder in a reciprocating mode. The ejection assembly is driven to penetrate through the interior of the protection assembly to do reciprocating motion; during minimally invasive surgery, firstly, the knife cylinder is placed into a wound hole, then when the driving assembly is driven, the driving assembly drives the ejection assembly to penetrate through the interior of the protection assembly to be ejected out, and in the process, the situation that tissue is damaged when the knife body passes through skin and organs and reaches a tumor part can be effectively prevented; and the alcohol cotton can be used for repeatedly disinfecting the ejection assembly while the ejection assembly is repeatedly used, so that the ejection assembly is always wiped by the alcohol cotton every time the knife is discharged.

The application provides a nano regulator and a preparation method and application thereof. Specifically, water regulation drugs and chemotherapy drugs are co-delivered through metal organic framework nanoparticles or metal polyphenol nanoparticles, the tumor-targeted enrichment and microenvironment-responsive release characteristics of the nano regulator are utilized to release the chemotherapy drugs at the tumor site after cryoablation. The nano regulator can be used for cryoablation sensitization and chemotherapy synergistic treatment, thereby effectively improving the tumor inhibition effect.

The present invention belongs to the field of medicine and relates to use of an iron-loaded carbon nanoparticle suspension injection for combined administration. The iron-loaded carbon nanoparticle suspension injection is administered in combination with an anticancer drug to inhibit tumor growth. In the combined administration, the anticancer drug is administered orally or intravenously, and the iron-loaded carbon nanoparticle suspension injection is administered via intratumoral injection. After the iron-loaded carbon nanoparticle suspension injection is injected into a tumor, it is found that the anticancer drug administered orally or intravenously is enriched in the tumor, thereby increasing the concentration of the anticancer drug in the tumor, enabling the anticancer drug to more accurately act on the tumor site, and reducing the dose of the anticancer drug and its toxic side effects on normal cells and tissues. The combined administration of the iron-loaded carbon nanoparticle suspension injection and the anticancer drug has a synergistic effect.

The invention discloses a copper naphthalocyanine liposome as well as a construction method and application thereof, and belongs to the technical field of liposome preparations. According to the copper naphthalocyanine liposome disclosed by the invention, the copper naphthalocyanine and the catalase are wrapped in the liposome, so that the problems of poor water solubility, insufficient stability and the like of an existing sound-sensitive agent can be improved; meanwhile, the nanomaterial has the effect of catalyzing excessive H2O2 in a brain glioma microenvironment to generate O2 to supply the O2 to a sonodynamic therapy (SDT) to continuously generate ROS, the sonodynamic performance of the nanomaterial is enhanced, the treatment effect of the brain glioma is improved, the nanomaterial has the advantages of good biological safety, low immunogenicity and in-vivo long circularity, and the nanomaterial can effectively penetrate through a blood brain barrier and is delivered to a tumor site, so that the nanomaterial has a good application prospect. The problems that in a traditional brain glioma treatment method, medicine cannot penetrate through the blood brain barrier easily and cannot reach the effective concentration are solved, and a new strategy is provided for treatment of brain glioma.

The application provides an embolism microsphere for regulating a tumor microenvironment and a preparation method and application thereof. The prepared embolism microsphere for regulating the tumor microenvironment is used for arterial tumor embolism, can embolize tumor blood vessels, block nutrition supply at a tumor site, and slowly and continuously release hydroxide in situ, neutralize lactic acid in the tumor microenvironment, regulate the weakly acidic tumor microenvironment, and improve the effect of chemotherapy, radiotherapy and immunotherapy.

The invention relates to the technical field of biological materials, in particular to a combretastatin targeted lipid drug delivery system and a preparation method thereof. According to the method, AS1411 and ApoE peptides are adopted to carry out joint modification on CA4 / HM-Fe lipidosome. Fe < 3 + > is introduced on the basis of the sound-sensitive agent HMME, so that the sound-sensitive agent HMME and the sound-sensitive agent HMME are self-assembled to form an HM-Fe complex, CA4 and free HMME are entrapped in a hydrophobic region, and HM-Fe is entrapped in a hydrophilic core, so that the HM-Fe complex can be used as a good carrier for delivering CA4, and the problem of poor water solubility of CA4 is effectively solved. The liposome is co-modified by AS1411 and ApoE peptide, so that dual active targeting of liver cancer cells and tumor vascular endothelial cells can be realized, the in-vitro uptake efficiency is effectively improved, and the enrichment efficiency of a drug at a tumor part is remarkably improved; the system is high in stability, low in toxicity, efficient, good in biocompatibility, high in tumor inhibition rate and good in tumor inhibition effect and safety.

The invention relates to the field of medicinal chemistry, in particular to a preparation method of boron-containing embolism microspheres for boron neutron capture therapy, which is used for solving the problems that the existing boron medicine has no tumor targeting property and is limited in treatment effect. According to the preparation method, the boron medicine is coated to form the microspheres, and the embolization microspheres containing the boron medicine are blocked at the tumor part through an intervention means, so that the preparation method has the three advantages that firstly, passive targeting is realized, and the microspheres release the boron medicine at the tumor part because the microspheres are blocked at the blood supply vessel of the tumor; controllable release of the medicine is achieved, distribution of the boron medicine in other tissues and organs is reduced, and side effects of the boron medicine are reduced; and thirdly, the microspheres can carry a chemotherapy drug or a developing agent while carrying a boron drug, so that the combination of boron neutron capture therapy and chemotherapy is realized, and the treatment effect is remarkably improved.