System and method for therapy and diagnosis comprising in combination non-mechanical and mechanical distributors for distribution of radiation

Abstract

A system and method for therapy and diagnosis of a human or animal. At least one coupling element for coupling of radiation couples radiation from at least a first radiation source to a tumour site and/or from said second radiation source to said site and/or from said site to a detector. The coupling elements are combinations of at least one translatory distributor, at least one rotary distributor, and at least one operation mode selector means for directing either said therapeutic radiation or said diagnostic radiation to said site through said at least one first radiation conductor. The system may be used for interactive interstitial photodynamic tumour therapy. The system and method according to the invention combines the advantages of purely mechanical and purely non-mechanical solutions in a new and synergetic way.

Description

FIELD OF THE INVENTION [0001] The invention relates generally to a system and a method for therapy and diagnosis in a subject. More particularly, the system and method relate to a system and method for tumour therapy and diagnosis in a human or animal. Even more particularly, the invention relates to a system and method for photodynamic therapy (PDT) and / or photothermal therapy (PTT) and / or photodynamic diagnosis (PDD) of a site on and / or in a body, wherein electromagnetic non-ionising radiation is conducted to the site for reaction with the radiation, wherein the system comprises at least one operation mode selector element for distribution of radiation from at least one source of radiation to a reaction site, and / or from the reaction site to at least one radiation sensor, respectively, and wherein the reaction site generally is a tumour site with a tumour, such as a malignant tumour. BACKGROUND OF THE INVENTION [0002] Within the field of medical therapy of tumour diseases, a plura...

AI Technical Summary

Benefits of technology

[0019] As already mentioned, the system combines the advantages of non-mechanical elements with the advantages of mechanical elements in an optimal way. Among others, these advantages of radiation elements comprise: high switching speed between different system operation modes (diagnosis, photodynamic therapy, thermal therapy); compactness and stability of the system; excellent radiation parameters; long life of the system due to no mechanical wear of the components and due to many more switching cycles during a life-cycle of the elements of the system. Examples of the advantages of mechanical elements comprise: easy manufacturing; inexpensive; readily available technology; efficient radiation transmission; low crosstalk. Yet a further advantage is an adaptation to effective consideration of power management

Problems solved by technology

In spite of great progress within therapy, the tumour diseases continue to account for much human suffering, and are responsible for a high percentage of deaths in western countries.

Singlet oxygen is known to be particularly toxic to tissue; cells are eradicated and the tissue goes in necrosis.

The limited penetration in the tissue of the activating radiation is a big drawback of PDT.

However, such open beam paths result in a strongly lossy beamsplitting and the resulting losses of light drastically impair the light distribution as well as the light measurement.

Furthermore, such a system must often be adjusted optically, which is also an important drawback in connection with clinical treatments.

The system is also large and heavy and difficult to integrate into a user-friendly apparatus.

Moreover, it is difficult to control the power of the light sent into each individual fibre, which makes the measurement results unreliable.

However, when changing from one constellation to another, the flexible wire has to be retracted between each switching process, otherwise the relative movement of the switch element is obstructed.

Furthermore, the pipelines are not suitable for conducting radiation themselves, they just provide external protection and guidance to the flexible wires conveyed therein.

The construction is also bulky and not suited for small optical fibres.

Moreover, the arrangement of the disclosure is not suited for diagnosis, only for therapy, and no interactive co-operation is disclosed.

However, only the use of a single wavelength light source is disclosed, it is thus not possible to h

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