The invention discloses a respiratory purification device, which comprises a medical oxygen generator, an airway, an oxygen filter box, a drying layer, an activated carbon adsorption layer, a HEPA filter, a primary filter, an overflow pipe, a round hole, a one-way valve, an oxygen Collection box, oxygen output pipe, plastic hose, mask, elastic belt, hanging ring, air inlet pipe and air outlet pipe, use medical oxygen generator to separate oxygen from indoor air, and send oxygen to oxygen filter box, medical oxygen generator Oxygen is delivered to the inside of the overflow pipe set at the bottom of the oxygen filter box through the air guide tube, and the filter system is formed through the layers of filters set on the upper part of the overflow pipe, which can fully remove the organic waste gas, odor, inhalable particulate matter and moisture in the oxygen. Absorption, allowing the patient to breathe clean oxygen. A bactericidal layer is wrapped outside the mouth of the trachea to suppress the bacteria in the exhaust gas exhaled by the patient.