A two-stage method for guiding an
endoscope and second device toward a target destination near the ROI includes navigation and localization. The
endoscope is navigated near the vicinity of the ROI according to a pre-procedure plan. When the ROI location is reached, the second device's tip is pushed far enough through the
endoscope so that its tip is outside the endoscope and in the endoscope'
s video view. Then a two-phase registration mechanism is used: i. Phase 1: Align the endoscope by registering the endoscope'
s video to a virtual bronchoscope's simulated video
stream; ii. Phase 2: Align the second device by registering the second device's shape in the endoscope'
s video to a virtual second device model.