55 results about "Benzisothiazolone" patented technology

The invention discloses an extreme-pressure metalworking liquid. The extreme-pressure metalworking liquid uses recovered oil as base oil, which not only enables cost to be saved but also allows environmental pollution to be reduced; the chlorine-containing extreme pressure agent chlorinated paraffin S52 and the sulfur-containing extreme pressure agent RC4801 are used as extreme pressure agents for the metalworking liquid, so the extreme-pressure metalworking liquid is suitable for machining with a great processing temperature range; benzisothiazolone and 3-iodine-2-propenyl-butylcarbamate are used as antiseptics, which enables the service life of a product to be prolonged. The metal processing liquid provided by the invention is suitable for a wide variety of machining, such as complex processing technologies like cutting, turning, drilling, grinding, boring and milling.

The invention discloses an anti-aging traditional Chinese painting pigment. The anti-aging traditional Chinese painting pigment is prepared from a color matrix, a dispersing agent, salicylic acid phenyl ester, a colloid, a light stabilizer, acrylic resin, a surfactant, a waterborne wetting agent, benzisothiazolone and deionized water, wherein a mixture of carrageenan and locust bean gum is adopted as the colloid. According to the anti-aging traditional Chinese painting pigment and a preparation method thereof, the anti-aging property of the pigment is improved by mainly adding the light stabilizer and adopting melamine resin with the anti-aging and antibacterial effects as a wall material of the pigment; by adding the mixture of the carrageenan and the locust bean gum which generate the synergistic effect, the moisture retention of the pigment can be improved.

The disclosure provides new compounds and compositions thereof, and methods for treating or ameliorating a disorder relating to CDG-Ia. In particular, the disclosure provides benzoisothiazolone inhibitors of PMI, which have been synthesized and their ability to drive glycosylation has been demonstrated. The disclosure provides two synthetic routes for these compounds, including a new copper-catalyzed N-arylation reaction amenable to parallel derivitization. The disclosed compounds represent potent inhibitors of PMI, and their dose-dependent efficacy in cell-based models of glycosylation have been demonstrated. In addition, the disclosed compounds are selective over PMM and therefore, are useful in treating or ameliorating a disorder relating to CDG-Ia.

The invention discloses corrosion-resistant long-acting antirust liquid. Raw materials of the corrosion-resistant long-acting antirust liquid comprise, by weight, 35-45 parts of compound corrosion inhibitor, 0.1-0.3 parts of a surface active agent, 0.2-0.4 part of hydroxy propyl cellulose, 0.3-0.5 part of polyethylene glycol, 0.1-0.3 part of a defoaming agent, 1-3 parts of sodium gluconate, 0.2-0.3 part of benzisothiazolones and 50-54 parts of water, wherein raw materials of the compound corrosion inhibitor comprise phytic acid, sodium molybdate, diethanol amine, monoethanolamine borate and 2-methyl benzimidazoline. According to the corrosion-resistant long-acting antirust liquid, by means of cooperation of the phytic acid, the sodium molybdate, the diethanol amine, the monoethanolamine borate and the 2-methyl benzimidazoline, the film forming speed of a protective film is increased, the corrosion speed is decreased, the thickness of the protective film is increased, corrosion media are prevented from making contact with metal, and the corrosion-resistant long-acting antirust liquid is made to have good corrosion-resistant performance and long-acting antirust performance.

The invention relates to the application of a biodegradable rolling emulsion composite in an aluminum alloy plate strip hot rolling technology. The biodegradable rolling emulsion composite is prepared from, by weight, 60-80 parts of vegetable oil and synthetic ester, 2-10 parts of at least one of oleic acid, triethanolamine and tall oil acid, 0-15 parts of at least one of petroleum sodium sulfonate, modified castor oil polyoxyethylene ether and alkylphenol polyoxyethylene ether, 0-5 parts of 12-14 alcohol, 0-10 parts of at least one of phosphite ester and phosphate ester, 1-5 parts of at least one of acid phosphate ester and isostearic acid, 0.5-2 parts of butylated hydroxytoluene, 0.05-1 part of octyl diphenylamine, 0.05-0.2 part of organosiloxane and 0.5-3 parts of at least one of methylene dimorpholine, iodo-n-butylproparglycarbamate and benzisothiazolones.

The invention discloses a waterproof weather-resistant acrylate exterior wall coating, comprising the following raw materials by weight: 20 to 30% of acrylate emulsion, 5 to 15% of ethylene-vinyl acetate copolymer emulsion, 20 to 30% of paraffin emulsion, 2 to 6% of propylene glycol monomethyl ether acetate and 40 to 50% of an accessory material. The acrylate emulsion is prepared through the following process procedures: placing 40 to 55 parts by weight of acrylate copolymer emulsion and 40 to 50 parts by weight of a silica sol in a reactor; carrying out high-speed uniform stirring at 65 to 70 DEG C; and then adding 2 to 4 parts of a coupling agent and 2 to 4 parts of modified sodium laurylsulfate and carrying out uniform stirring. The accessory material comprises, by weight, 10 to 16 parts of barite powder, 10 to 15 parts of wollastonite powder, 15 to 20 parts of titanium dioxide, 0.5 to 1.3 parts of a wetting dispersant, 1.5 to 3 parts of an antifoaming agent, 1 to 1.5 parts of hydroxyethyl cellulose, 1 to 1.8 parts of 1,2-benzoisothiazole-3-one, 1 to 1.2 parts of ammonia water and 6 to 12 parts of water.

The invention provides a concentrated garment washing solution, which is prepared from the following main components in parts by mass: 3 to 35 parts of anionic surfactant, 6 to 25 parts of isomeric alcohol ether surfactant, 8 to 18 parts of nonionic surfactant, 3 to 12 parts of zwitterionic surfactant, 0.1 to 2 parts of biological enzyme, 0.1 to 0.3 part of benzisothiazolone, 0.1 to 0.8 part of essence and 15 to 65 parts of deionized water. The concentrated garment washing solution provided by the invention is excellent in washing effects, friendly to a human body and an environment, green andenvironmentally friendly.

A process for the sysnthesis of oligonucleotides using phosphoramidite chemistry is provided. The process employs as activator a 1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one, preferably in the presence of an organic base. The 1,1-dioxo-1,2-dihydro-1λ⁶-benzo[d]isothiazol-3-one is represented by the following structural formula:

wherein p is 0 or an integer from 1 to 4; X⁷ is O or S; R for each occurrence is a substituent, preferably each independently, a halo, a substituted or unsubstituted aliphatic group, —NR¹¹R¹², —OR¹³, —OC(O)R¹³, —C(O)OR¹³, or cyano; or two adjacent R groups taken together with the carbon atoms to which they are attached form a six membered saturated or unsaturated ring; R¹¹ and R¹² are each, independently, —H, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group; and R¹³ is a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aralkyl group. Preferred organic bases are pyridine, 3-methylpyridine, or N-methylimidazole.

The invention discloses a novel synthesis method of an N-substituted benzisothiazoline-3-ketone derivative. The preparation method comprises the following steps: by taking a dithiosalicylic acid derivative and sulfur as raw materials, introducing chlorine or bromine to obtain a halogenated thiobenzoyl halide derivative, then preferably dropwise adding a mixed solution of primary amine and tertiaryamine, and carrying out reaction and ring closing to obtain the N-substituted benzisothiazole-3-ketone. The method disclosed by the invention is simple in process, safe and controllable, and easy forindustrial large-scale production.

The invention discloses an aerolite cutting fluid with low PH value and its preparation method, and belongs to the domain of the cutting fluid. The cutting fluid is prepared from, by weight ratio, trimethylolpropane trioleate, tall oil, triethanolamine, neodecanoic acid, phosphate, benzisothiazolone, hard water resisting agent, tribasic acid, benzotriazole, castor oil polyoxyethylene ether, trihydroxy hexahydro-s-triazine, and 2, 6-bismethylmorpholine; the allowance is water. The aerolite is extremely sensitive to alkalinity; the cutting solution has low PH value due to its special preparation method and composition, and the PH value is ranged from 8.0 to 8.3; the cutting fluid is free from corrosion to the aerolite and magnalium zinc alloy which are extremely easy to corrode; moreover, the class 2 and class 7 aluminum alloys in the aerolite are big in hardness and not easy to process. The cutting solution has excellent lubricating performance and can be used for cutting during the process conveniently; the surface smoothness is high.

The invention discloses a scale inhibitor of reverse osmosis membranes and relates to the field of chemical processes. The composition is prepared from polyepoxysuccinic acid, sodium polystyrene sulfonate, poly aspartic acid, polylactic acid, dimethyldistearylammonium bromide, benzisothiazolones and deionized water. The phosphate-free scale inhibitor of reverse osmosis membranes is capable of efficiently removing inorganic scales and colloid scales deposited on reverse osmosis membranes; in the formula, several phosphate-free or low-phosphate environment-friendly materials are used in combination, the use effect of the composite agent is greatly improved through the synergistic effect among the raw materials, and satisfactory comprehensive scale removing performance is achieved; meanwhile, by means of the phosphate-free formula and addition of a small amount of the green fungicide benzisothiazolones, the potential danger of biological pollution and bacterium standard exceeding of membrane systems can be relieved, and pollution to the environment water source is avoided.

The invention discloses benzimidazole isothiazolinone amide derivatives and a synthetic method thereof; the series of compounds are compounds represented by the general formula (I), wherein R is 4-methyl, 3-chlorine or 2,4-dimethyl. The synthetic method is characterized by comprising the following steps: taking substituted aniline and benzisothiazolone acetic acid having the molar ratio of 1:(1-1.5), and taking HoBt and EDCI as condensing agents, wherein the molar ratio of substituted aniline to the condensing agent HoBt is (1:1.1)-(1:1.3), and the molar ratio of substituted aniline to the condensation agent EDCI is (1:1.1)-(1:1.3); completely dissolving the raw materials by an organic solvent, and carrying out a reaction for 16-24 h at room temperature; after completion of the reaction, pouring the solution into water, precipitating a large number of solids, filtering, pickling, washing with water, drying, and thus obtaining a crude product; and carrying out column chromatography to obtain the benzisothiazolone derivatives. The preparation process is easy to industrialize, and the target product has good biological activity.

The invention discloses a high and low temperature resistant coating which comprises the following raw materials in parts by weight: 50-70 parts of a modified acrylic resin emulsion, 20-30 parts of a waterborne polyurethane emulsion, 10-15 parts of water, 2-3 parts of propanediol butyl ether, 15-20 parts of montmorillonite, 10-15 parts of kaolin, 1-2 parts of sodium dodecyl sulfonate, 2-3 parts of dodecyl dimethyl phosphate betaine, 0.03-0.05 part of pentaerythritol polyoxyethylene polyoxypropylene ether, 0.04-0.06 part of polydimethylsiloxane, 0.3-0.4 part of a wetting agent Tego270, 0.2-0.3 part of a flatting agent, 0.3-0.4 part of polyacrylamide, 0.1-0.2 part of polyvinyl alcohol and 0.03-0.05 part of benzisothiazolone. The high and low temperature resistant coating disclosed by the invention is good in high and low temperature resistance, good in water resistance, high in mechanical property and good in corrosion resistance.

The invention creatively provides a labeling reagent and a labeling method for schizopygopsis younghusbandi. The labeling reagent comprises a fluorescence labeling mixture and a cactus extract, wherein the fluorescence labeling mixture comprises a fluorescence marker, n-butylbenzisothiazolone and vitamin K3, wherein a mass ratio of the fluorescence marker to the n-butylbenzisothiazolone to the vitamin K3 in the fluorescence labeling mixture is 1: (5-10): (1-3), and the addition amount of the cactus extract is that 30-100 mL of the cactus extract is added per gram of the fluorescence labeling mixture. The labeling reagent and the labeling method for schizopygopsis younghusbandi provided by the invention have the advantages that the damage to schizopygopsis younghusbandi is small, and toxic and side effects are avoided; a label formed on the otolith of schizopygopsis younghusbandi has good stability, is not influenced by the outside and can be stored permanently; and large-scale releasing labeling activities can be achieved through one-time marking, and the influence of manual operation on fish fries is reduced to the maximum extent.

The invention discloses a water treatment sterilization agent and a preparation method thereof, and belongs to the technical field of preservatives. The key points of the technical scheme are as follows: the sterilization agent comprises the following raw materials: octyl isothiazolinone, zinc pyrithione, a stabilizer, 2-methyl-1,2-benzisothiazol-3-one and water; the preparation method comprises the following steps: weighing the octyl isothiazolinone, the zinc pyrithione, the stabilizer, the 2-methyl-1,2-benzisothiazol-3-one, glutaraldehyde, bis[tetrakis(hydroxymethyl)phosphonium] sulfate, a cationic surfactant and water in percentage by weight, sequentially adding the weighed substances into a container, and stirring for 30 minutes or longer to obtain the emulsion preservative. The effects of improving the spectral sterilization performance of the sterilization agent and preventing microorganisms from generating drug resistance are achieved.

The invention discloses aluminum profile environment-friendly composite chromate-free passivation conditioning fluid. The aluminum profile environment-friendly composite chromate-free passivation conditioning fluid comprises, by weight, 9.6-10 parts of cerous nitrate, 2-2.2 parts of potassium permanganate, 0.2-0.3 part of glycerin, 0.1-0.2 part of benzisothiazolones, 1.2-1.3 parts of K2ZrF6, 0.6-0.8 part of styrene, 0.2-0.3 part of acrylamide, 0.4-0.5 part of crylic acid, 0.05-0.1 part of azodiisobutyronitrile, 0.5-0.6 part of sodium allylsulfonate, 0.02-0.03 part of lauryl sodium sulfate, 0.9-1 part of cetane, 0.3-0.4 part of nanosilicon dioxide, 0.3-0.4 part of nanometer titania and an appropriate amount of deionized water. By means of the conditioning fluid, an oxidation film can be rapidly formed evenly; the glycerin, the benzisothiazolones and the K2ZrF6 are used, so that film-forming property and the corrosion resistance are improved; the film is rough in surface; and the binding ability of the aluminum alloy and a macromolecule coating is better improved.

The invention discloses an environment-friendly neutral aluminum alloy cleaning agent and a preparation method thereof. The environment-friendly neutral aluminum alloy cleaning agent comprises the following components in percentages by weight: 1-3% of edetate disodium, 6-10% of polyethylene oxide, 10-20% of a surfactant 502, 1-5% of silanone, 0.3-0.8% of 1, 2-benzisothiazole-3-one, 0.2-0.3% of hydrated sodium silicate, 0.1-0.3% of benzotriazoles, 0.1-0.2% of sodium citrate, 0.1-0.2% of D-sodium gluconate, 2-6% of a pH value regulator and the balance of water. The environment-friendly neutral aluminum alloy cleaning agent is harmless to the environment and human bodies; the cleaning rate is high, and cleaned products are free of undesirable phenomena such as discoloration, mildewing and white spots; foams are less during use, and the surface states of the products are observed conveniently; and the product is free of phosphorus and nitrogen and neutral in pH value, so that waste liquidtreatment is facilitated, and the treatment cost is reduced.

The invention relates to a quantum energy multifunctional interior wall coating and a preparation method thereof, belongs to the technical field of coatings, and solves the problems that existing interior wall latex paint is prone to cracking, poor in stain resistance and limited in negative ion release effect. The coating is prepared from the following components in parts by weight: 20-30 parts of styrene-acrylic emulsion, 1.5-2.5 parts of styrene-acrylic emulsion thickener, 0.8-1.5 parts of simethicone, 0.5-1 part of propylene glycol, 1-2 parts of quantum dots, 3-5 parts of nano titanium dioxide, 1-3 parts of porous cellulose microspheres, 1-2 parts of 1, 2-benzoisothiazole-3-ketone, 0.2-0.5 part of zinc oxide, 1-1.2 parts of perhydropolysilazane, 3-8 parts of a water-based dispersing agent, 2-4 parts of a water-based defoaming agent, 2-4 parts of a nonionic surfactant, 2-5 parts of titanium dioxide and the like. The coating is high in adhesive force, resistant to scrubbing and contamination, not prone to cracking, resistant to bacteria and mildew and capable of releasing negative ions and purifying air.

The invention relates to a benzo[d]isothiazole-3-(2H)-one derivative, a preparation method and application of the benzo[d]isothiazole-3-(2H)-one derivative. The compound is a free alkali or salt of acompound with a structure shown in a general formula (I). The salt is one of hydrochloride, hydrobromide, sulfate, trifluoroacetate, tartrate, lactate or mesylate; R1 independently represents "-CH2-CO-" or "-CH2-CH2-"; R2 independently represents "-CH2-CH2-O-" or "-CO-CH=CH-"; R3 independently represents hydrogen, halogens, a hydrocarbon group, a halogen-substituted hydrocarbon group, a nitro group, an amino group, a nitrile group, a hydroxyl group, an alkoxy group, an aryloxy group, a heterocycloalkoxy group, an aryl group, a substituted heterocyclic ring or a substituted aryl group. The invention also provides an application of the benzo[d]isothiazole-3-(2H)-one derivative in preparation of ischemic stroke treatment medicines.

The invention discloses a 2-(hydroxybenzyl) benzo [d] isothiazolone compound (I), pharmaceutically acceptable salts thereof, a preparation method of the compound, a pharmaceutical composition of the compound and application of the compound in preparation of drugs for treating and/or preventing nervous system related diseases, comprising but not limited to vascular dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV-related dementia disease, multiple sclerosis, amyotrophic lateral sclerosis, neuropathic pain, glaucoma, ischemic cerebral apoplexy, hemorrhagic cerebral apoplexy, nerve injury caused by cerebral trauma and other diseases.

A composition, suitable for topical application to the skin, containing at least one benzoisothiazolone of formula (I):

Novel benzoisothiazolones of formula (I) and a method of caring for dry and/or mature skin.

The invention discloses a compound having an isothiazolinone and N-arylpyrazole and a preparation method and application thereof. The method for preparing the compound having the isothiazolinone and N-arylpyrazole structure according to the invention comprises the following steps: enabling a compound represented by the formula (II) to react with a benzisothiazolone sodium salt in an organic solvent by using potassium iodide as a catalyst in an oil bath at a temperature of 100 to 105 DEG C for 4.5 to 5 h; after the reaction is completed, concentrating a solvent, pouring into water, precipitating a large amount of solid, performing suction filtration, washing, drying to obtain a crude product, and obtaining a target product of the formula (I) by column chromatography. The compound disclosedby the invention is a compound having the isothiazolinone and N-arylpyrazole structure, has good biosuppressive activity, has good biological activity in sterilizing, controlling algae and killing mollusc, has a certain corrosion inhibition effect, and has broad application prospects in seawater circulating cooling water. The formula (I) is shown in the specification.

The invention discloses a waterproof and high-strength water-based paint comprising the following raw materials in parts by weight: 9-13 parts of deionized water, 0.3-0.5 part of a mixed thickener, 0.1-0.14 part of triethanolamine, 0.2-0.4 part of a wetting agent Wet500, 3-5 parts of an LBCB-1 thixotropic lubricating agent, 15-22 parts of titanium dioxide, 8-12 parts of zinc stearate, 13-17 parts of heavy calcium powder, 100-120 parts of a modified polyurethane emulsion, 2-2.6 parts of ethylene glycol monobutyl ether, 1.5-2.5 parts of methoxybutanol, 1-1.5 parts of alcohol ester-12, 0.4-1 part of propylene glycol, 0.1-0.2 part of benzisothiazolones, 0.1-0.2 part of N-octyl-4-isothiazolin-3-ketone, 0.3-0.5 part of a mixed defoaming agent, 0.4-0.6 part of an organic silicon flatting agent and 0.1-0.3 part of polysiloxane polymer compounds. The waterproof and high-strength water-based paint is good in mechanical property, high in tensile strength, strong in tear resistance and good in waterproofness.

The invention discloses a hot melt adhesive and a production method thereof, and belongs to the technical field of chemical industry. The hot melt adhesive is prepared from, by weight, 10-20 parts ofdibutyl phthalate, 5-10 parts of triethanolamine, 4-10 parts of epoxy propane phenyl ether, 2-8 parts of benzisothiazolone, 2-10 parts of polyurethane resin, 5-9 parts of hydroxypropyl distarch phosphate, 2-10 parts of N-methylpyrrolidone, 3-9 parts of peroxide hydroxyl diisopropylbenzene, 1-5 parts of Furfuryl alcohol resin, 4-10 parts of antioxidants and 2-6 parts of cross-linking agents. The hot melt adhesive has excellent hot melt performances and cohesiveness, can be normally used at the high temperature and is simple to product, low in cost and excellent in performance.

The invention provides a bactericidal diol chain extender. The structural formula of the chain extender is shown in the specification. The chain extender is prepared by the following steps: dissolving dibromo-octyl pentanediol and 1,2-benzisothiazole-3-ketone in a solvent, putting into a microwave reactor, reacting at 22222 DEG C for 2212 hours, and purifying to obtain the diol chain extender containing bactericidal groups, wherein the molar ratio of the dibromo-octyl pentanediol to the 1,2-benzisothiazole-3-ketone is 1.2 to 2.222.5. The invention also provides an application of the diol chain extender in multifunctional synergistic anti-fouling waterborne polyurethane. The bactericidal diol chain extender is applied to preparation of anti-fouling waterborne polyurethane, bactericidal groups are introduced into a coating through covalent bonds, compared with a release type anti-fouling coating, the environmental toxicity can be effectively reduced, and the prepared anti-fouling waterborne polyurethane can be widely applied to textile, plastic, medical treatment and public health and the like, especially the marine anti-fouling field; and on the other hand, the environment is not polluted, the production cost of the product can be reduced, and energy is saved.