Benzisothiazolone derivative and preparation method and application thereof

A technology of benzisothiazolone and derivatives, applied to benzisothiazolone derivatives, preparation of benzisothiazolone derivatives, application fields of benzisothiazolone derivatives in antifungal and antibacterial , can solve the problems of VOC, easy to lose, easy to be absorbed by the human body, etc., and achieve the effect of not easy to absorb, not easy to lose, and excellent mildew resistance

Active Publication Date: 2017-08-08
SHOUGUANG SYNTECH FINE CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The object of the present invention is to provide a new antifouling agent capable of overcoming the above defects in order to overcome the problems of VOC and easy loss and absorption by the human body when the antifouling agent formed by the benzisothiazolone compound provided by the prior art is compounded. Benzisothiazolone derivatives with good anti-mold and bactericidal effects

Method used

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  • Benzisothiazolone derivative and preparation method and application thereof
  • Benzisothiazolone derivative and preparation method and application thereof
  • Benzisothiazolone derivative and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] In the presence of 450g of DMF and 107g of sodium carbonate, 185.5g of 5-chloro-1,2-benzisothiazol-3-ketone and 80g of brominated paraffin (halogen atom content is 40-44% by weight, purchased from Wuyi Diwang Chemical Auxiliary Co., Ltd.) for reflux reaction for 10 hours, washed with water after the reaction (the unreacted raw material 5-chloro-1,2-benzisothiazol-3-one was washed away), and the crude product , decolorized to obtain benzisothiazolone derivative M1, the yield (based on 5-chloro-1,2-benzisothiazol-3-one, the same below) was 92%.

Embodiment 2

[0050] In the presence of 400g of DMF and 80g of lithium carbonate, 165g of 5-methyl-1,2-benzisothiazol-3-ketone and 90g of chlorinated paraffin (halogen atom content is 50-54% by weight, , purchased from Yangzhou Keli Chemical Co., Ltd.) for reflux reaction for 15h, washed with water after the reaction (the unreacted raw material 5-methyl-1,2-benzisothiazol-3-one was washed away), and the crude product was obtained. After decolorization, the benzisothiazolone derivative M2 was obtained with a yield of 93%.

Embodiment 3

[0052] In the presence of 500g of acetonitrile and 139g of potassium carbonate, 151g of 1,2-benzisothiazol-3-one and 80g of chlorinated paraffin (halogen atom content is 68-72% by weight, purchased from Yangzhou Keli Chemical Co., Ltd.) for reflux reaction for 20h, after the reaction was completed, washed with water (the unreacted raw material 1,2-benzisothiazol-3-one was washed away), obtained the crude product, decolorized, and obtained benzisothiazolone derivatives M3, 92% yield.

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Abstract

The invention belongs to the field of chemical mold prevention and bacteria resistance, and discloses a benzisothiazolone derivative and a preparation method and application thereof. The derivative is prepared from a compound shown as a formula (1) which substitutes halogen atoms halogen atoms in at least one halogenated paraffin selected from chlorinated paraffin and brominated paraffin, wherein the halogen atom content of the halogenated paraffin is 10 to 80 percent by weight, and the quantity of carbon atoms in the halogenated paraffin is 13 to 30. The benzisothiazolone derivative provided by the invention has superior anti-mold and anti-bacterial effects, is free from VOCs problem (Volatile Organic Compounds) produced due to compounding with a solvent, is prevented from being lost, is difficult to be absorbed by human body, and is environment-friendly; moreover, the production cost is lowered. The formula (1) is shown in the description.

Description

technical field [0001] The present invention relates to the field of chemical antifungal and antibacterial, in particular to benzisothiazolone derivatives, a method for preparing benzisothiazolone derivatives and benzisothiazolone derivatives prepared by the method, and It relates to the application of benzisothiazolone derivatives in antifungal and antibacterial. Background technique [0002] The structural formula of 1,2-benzisothiazol-3-one compound is as follows: [0003] [0004] Among them, R 1 Represents H, Cl, Br, C 1 -C 4 of alkyl. [0005] 1,2-benzisothiazol-3-one compounds have good anti-mold and bactericidal effects, but the utilization of 1,2-benzisothiazol-3-one compounds needs to be dissolved in organic solvents for compounding , This greatly increases the production cost, and at the same time brings the VOC problem. [0006] In addition, small molecule 1,2-benzisothiazol-3-one compounds are easily lost, and at the same time, this small molecule fungi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D275/04A01N43/80A01P3/00A01P1/00
CPCA01N43/80C07D275/04
Inventor 戴明本
Owner SHOUGUANG SYNTECH FINE CHEM
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