31 results about "Steatonecrosis" patented technology

Methods and devices are described for the regulation of Transforming Growth actor (TGF)-β1, β2, and / or β3 protein gene expression in bone cells and other tissues via the capacitive coupling or inductive coupling of specific and selective electric fields to the bone cells or other tissues, where the specific and selective electric fields are generated by application of specific and selective electric and electromagnetic signals to electrodes or one or more coils or other field generating device disposed with respect to the bone cells or other tissues so as to facilitate the treatment of diseased or injured bone and other tissues. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone and other tissue that include generating specific and selective electric and electromagnetic signals that generate fields in the target tissue optimized for increase of TGF-β1, β2, and / or β3 protein gene expression and exposing bone and other tissue to the fields generated by specific and selective signals so as to regulate TGF-β1, β2, and / or β3 protein gene expression in such tissue. The resulting methods and devices are useful for the targeted treatment of bone fractures, fractures at risk, delayed unions, nonunion of fractures, bone defects, spine fusions, osteonecrosis or avascular necrosis, as an adjunct to other therapies in the treatment of one or all of the above, in the treatment of osteoporosis, and in other conditions in which TGF-β1, β2, and / or β3 protein may be implicated.

Methods and devices are described for the regulation of Fibroblastic Growth Factor-2 mRNA and / or FGF-2 protein in bone cells and other tissues via capacitive coupling or inductive coupling of specific and selective electric and / or electromagnetic fields to the bone cells or other tissues, where the specific and selective fields are generated by application of specific and selective signals to electrodes or one or more coils or other field generating device disposed with respect to the bone cells or other tissues so as to facilitate the treatment of diseased or injured bone and other tissues. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone and other tissue that include generating specific and selective signals that generate electric and / or electromagnetic fields in the target tissue optimized for increase of FGF-2 protein gene expression and exposing bone and other tissue to the fields generated by specific and selective signals so as to regulate FGF-2 protein gene expression in such tissue. The resulting methods and devices are useful for the targeted treatment of osteoporosis, osteopenia, osteonecrosis, fresh bone fractures, fractures at risk, nonunion, bone defects, spine fusion, and / or other conditions in which FGF-2 protein has been implicated.

The invention discloses a medicine for preventing medicine-related osteonecrosis of the jaw. The medicine uses a DNA tetrahedron as an effective ingredient. Experiments show that the DNA tetrahedron can reverse the inhibitory effect of zoledronic acid, dexamethasone and other medicines on osteoclast, and can relatively well prevent medicine-related osteonecrosis of the jaw.

The invention consists of an electronic system for controlled and independent treatment of fractures, bone, muscle and tendon injuries, post-surgery pain and osteonecrosis, composed by a portable ultrasound generator, electronic prescription, centralised web services platform and computer program for ultrasonic treatment both within and outside the sanitary field, in the fields of human and veterinary medicine. The method controls the treatment applied, the charge prescribed by healthcare professionals by means of an electronic prescription, which can be administered by the patients themselves or by non-healthcare professionals independently, under the control of a computer program and a web platform used to activate the therapeutic equipment, write and delete the electronic prescription, transfer data stored in the therapeutic equipment to the web services platform to analyse the quantity and quality of the treatments, and update the program. Portable generator of ultrasonic pulses with set, unalterable parameters for the treatment of thorax, rib and sternum fractures, and of pain after thoracic surgery.

Methods of treating osteonecrosis in a subject are provided. In some embodiments, the method comprises administering to a subject having or suspected of having osteonecrosis a pharmaceutical composition comprising a conjugate of an LLP2A peptidomimetic ligand and a bisphosphonate drug. In some embodiments, the pharmaceutical composition comprises a conjugate of LLP2A and alendronate (LLP2A-Ale). In some embodiments, the method further comprises administering exogenous mesenchymal stem cells.

The invention pertains to the use of mesenchymal stromal cells (MSC) in the treatment of bone disorders or injuries. The invention provides MSC and preparations of specifically pooled MSC for use in the manufacturing of bone graft material for implanting into or attaching to bones in order to enhance bone regeneration after surgery or injury, or to treat various bone disorders, such as osteonecrosis. The invention provides bone graft material, a method for its production, bone graft implants, and medical methods and uses of the inventive products.

The invention particularly relates to a traditional Chinese medicine for treating bone fracture and osteonecrosis and a preparation method thereof. The traditional Chinese medicine for treating bone fracture and osteonecrosis is prepared from the following components in parts by mass: 2 to 4 parts of tree hair, 6 to 8 parts of dragon's blood, 8 to 10 parts of frankincense, 8 to 10 parts of myrrh, 5 to 7 parts of sambucus chinensis, 4 to 6 parts of semen momordicae, 30 to 40 parts of semen vaccariae, 2 to 4 parts of saffron crocus, 1 to 2 parts of fructus amomi rotundus, 2 to 4 parts of acanthopanax seeds, 7 to 10 parts of synthetic bone setting pills and 8 to 14 parts of radix notoginseng. The preparation method of the traditional Chinese medicine for treating bone fracture and osteonecrosis comprises the following steps: repeatedly calcining the synthesized bone setting pill, quenching with concentrated vinegar, breaking the wall into particles, sieving with a 240-mesh sieve, mixing with various medicines, sterilizing for 3-5 hours under an ultraviolet lamp, and filling into capsules or tabletting. The traditional Chinese medicine is short in bone fracture disease treatment time, good in effect and free of adverse reactions and side effects.

The invention belongs to the technical field of the traditional Chinese medicine, which in particular discloses a bone recovering pill for treating bone necrosis. The bone recovering pill is prepared from antler, radix clematidis, tortoise shell, twotooth achyranthes root, safflower, curculigo orchioides, prepared rehmannia root, radix notoginseng, angelica, radix morindae officinalis, astragalusroot, draconis sanguis, eucommia bark and rhizoma drynariae according to certain weight mixture ratio. The invention has the effects of induing menstruation to relieve menalgia, reinforcing the kidney to strengthen the bone, invigorating qi, tonifying the blood, promoting blood circulation and relieving the stasis of blood and has reasonable matching, coincidence of the medicine and the disease, positive curative effect and no side effect.

The invention discloses a medicinal composition for treating rheumatism and rheumatoid arthritis. The medicinal composition consists of more than 20 medicaments, such as fortune's drynaria rhizome, processed nux vomica, scorpion, himalayan teasel root, frankincense, myrrh, diversifolious patrinia root and the like and has no side effect of chemical medicaments. The medicinal composition has the effects of drilling tendon, penetrating bone, activating tendons, expelling wind, relieving pain and eliminating stagnation and has the remarkable treatment effects of treating the rheumatism, the rheumatoid arthritis, scapulohumeral periarthritis, sciatica, gout, cervical spondylosis, herniated disk, hyperosteogeny, osteonecrosis and lupus erythematosus.

The invention discloses an application of a traditional Chinese medicine composition in the preparation of medicines or health care products for treating osteoporosis and osteonecrosis. The traditional Chinese medicine composition of the present invention is made of Polygonum multiflorum, Polygonatum, Rehmannia glutinosa, Gorgon fruit, Ziheche, black sesame, Astragalus, Poria cocos, Chinese yam, American ginseng, Radix asparagus, Ophiopogon japonicus, pearl, amber, keel, arborvitae leaves, black soybean to make. Pharmacodynamic experiments show that the Chinese medicine composition of the present invention can increase the bone density of osteoporosis model rats and serum calcium and phosphorus levels; it can increase the distribution of capillaries in the femoral head of rats with steroid-induced necrosis of the femoral head, and reduce the distribution of steroid-induced necrosis of the femoral head model. Fat deposits in the femoral head bone tissue of rats, and clinical research results also show that the traditional Chinese medicine composition of the present invention has a good therapeutic effect on osteoporosis and femoral head necrosis. The traditional Chinese medicine composition provided by the invention has the advantages of good curative effect and small side effects in treating osteoporosis and osteonecrosis, and has good clinical application prospect.

The composition of the Chinese medicine with the functions of effectively improving blood circulation of bone, raising volume of blood flow, reducing internal pressure of bone, inhibiting platelet aggregation, reducing osteonecrosis and promoting osteonecrosis regeneration for curing ischemic necrosis of femoral head is formed from 12 Chinese medicinal materials of notoginseng, ligusticum root, cordydalis tuber, Chinese angelica root, saussurea root, millettia root and stem and others.

The invention discloses a novel LDH nanosheet material, AL / LDH material and a preparation method of the two materials and their application in preparing bone regeneration materials for treating femoral head necrosis, bone defect and / or osteoporosis. The LDH component prepared by the present invention is a Mg-Al-Yb monolayer hydroxide, and sodium alendronate is loaded on the surface of the LDH through the interaction of hydrophilic groups. LDH and AL / LDH are used to accelerate bone regeneration in the area of ​​osteonecrosis. While accelerating bone regeneration at the material implantation site, AL / LDH can also promote the increase of bone density outside the necrosis area. At present, the main method for the clinical treatment of early femoral head necrosis is: heart medullary decompression combined with bone transplantation, AL / LDH and LDH can be used as bone graft materials after heart medullary decompression, and, for patients with systemic osteoporosis In patients, the use of AL / LDH as material filling in necrotic areas can help improve the bone density of the whole body.

[Problem] To provide an agent for preventing the onset of idiopathic osteonecrosis of the femoral head and / or suppressing the progress of the same. [Solution] An agent for preventing the onset of idiopathic osteonecrosis of the femoral head and / or suppressing the progress of the same comprising parathyroid hormone or a derivative thereof as an active ingredient, characterized by being administered intermittently.

An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical and physiological condition. The device distinguishes different segments mimicking anatomically-relevant cortical and cancellous segments, in which the cortical segments of the device can sustain mechanical loading, and the cancellous segment of the device can promote bone ingrowth, osteogenesis and angiogenesis.