32 results about "Steatonecrosis" patented technology

Methods and devices are described for the regulation of Fibroblastic Growth Factor-2 mRNA and / or FGF-2 protein in bone cells and other tissues via capacitive coupling or inductive coupling of specific and selective electric and / or electromagnetic fields to the bone cells or other tissues, where the specific and selective fields are generated by application of specific and selective signals to electrodes or one or more coils or other field generating device disposed with respect to the bone cells or other tissues so as to facilitate the treatment of diseased or injured bone and other tissues. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone and other tissue that include generating specific and selective signals that generate electric and / or electromagnetic fields in the target tissue optimized for increase of FGF-2 protein gene expression and exposing bone and other tissue to the fields generated by specific and selective signals so as to regulate FGF-2 protein gene expression in such tissue. The resulting methods and devices are useful for the targeted treatment of osteoporosis, osteopenia, osteonecrosis, fresh bone fractures, fractures at risk, nonunion, bone defects, spine fusion, and / or other conditions in which FGF-2 protein has been implicated.

The invention discloses a novel LDH nanosheet material, AL / LDH material and a preparation method of the two materials and their application in preparing bone regeneration materials for treating femoral head necrosis, bone defect and / or osteoporosis. The LDH component prepared by the present invention is a Mg-Al-Yb monolayer hydroxide, and sodium alendronate is loaded on the surface of the LDH through the interaction of hydrophilic groups. LDH and AL / LDH are used to accelerate bone regeneration in the area of ​​osteonecrosis. While accelerating bone regeneration at the material implantation site, AL / LDH can also promote the increase of bone density outside the necrosis area. At present, the main method for the clinical treatment of early femoral head necrosis is: heart medullary decompression combined with bone transplantation, AL / LDH and LDH can be used as bone graft materials after heart medullary decompression, and, for patients with systemic osteoporosis In patients, the use of AL / LDH as material filling in necrotic areas can help improve the bone density of the whole body.

An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical and physiological condition. The device distinguishes different segments mimicking anatomically-relevant cortical and cancellous segments, in which the cortical segments of the device can sustain mechanical loading, and the cancellous segment of the device can promote bone ingrowth, osteogenesis and angiogenesis.