Strontium-Containing Compounds for Use in the Prevention or Treatment of Necrotic Bone Conditions

Inactive Publication Date: 2008-07-10
OSTEOLOGIX AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006]Accordingly, the present invention relates to a method for the treatment and/or prophylaxis of an osteonecrotic bone disease in a mammal in need thereof, such as, e.g., idiopathic or secondary osteonecrosis, avascular bo

Problems solved by technology

Although diagnostic methods for its identification have improved in recent years with the introduction of new sensitive high resolution MRI and other imaging techniques, no effective therapeutic agents or medical interventions have yet been developed to prevent and/or treat this condition.
In some

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Effect of Strontium Malonate in an Animal Model of Osteonecrosis

[0065]The rationale for the study was to assess the ability of strontium to act as a therapeutic and bone growth promoting (i.e. pro-anabolic) agent in an animal model of osteonecrosis. In this model, a syngenic necrotic bone graft was implanted into the femur of a recipient rat. The necrotic graft was degraded, while ingrowth of new bone occurred. At termination of the experiment, the structural grafts was removed and analyzed by histology to quantify both the degradation of the necrotic graft as well as ingrowth of new bone. Concomitant treatment with anabolic and / or anti-resorptive agents may be given after the insertion of the necrotic graft, and the effect monitored after termination of the experiment. This rat model has previously been described (Åstrand J, Aspenberg P. BMC Musculoskelet Disord. 2002; 3(1):19).

Methods and Materials

[0066]The compounds (active strontium test-article: Sr-malonate, 189.6 g / mol; Placeb...

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Abstract

A method for the treatment and/or prophylaxis of an ostenonecrotic bone disease in a mammal in need thereof, such as, e.g., idiopathic or secondary osteonecrosis, avascular bone necrosis, glucocorticoid induced bone ischemia/osteonecrosis, Legg-Calve-Perthes disease and femoral head necrosis, the method comprising administering an effective dose of a strontium-containing compound (a) to the mammal. A method for the treatment and/or prophylaxis of an osteonecrotic bone disease, such as, e.g., idiopathic or secondary osteonecrosis, avascular bone necrosis, glucocorticoid induced bone ischemia/osteonecrosis and femoral head necrosis, in a mammal who is to be or is treated with a therapeutic agent (b) known to or suspected of inducing apoptosis and/or necrosis of bone cells, the method comprising administering a strontium-containing compound (a) in combination with (b).

Description

FIELD OF THE INVENTION[0001]The present invention relates to methods for the treatment and / or prophylaxis of necrotic bone conditions and pharmaceutical compositions for use in such treatments.BACKGROUND OF THE INVENTION[0002]Necrotic bone conditions, such as idiopathic or secondary osteonecrosis, avascular bone necrosis, glucocorticoid induced bone ischemia / osteonecrosis, Legg-Calve-Perthes disease and femoral head necrosis are severe debilitating conditions. These conditions can be associated with medical interventions such as high dose glucocorticoid therapy and various treatments for HIV / AIDS, or they can arise spontaneously in susceptible individuals or as a consequence of other diseases such as Cushing syndrome, Storage diseases (i.e. Gauchers disease), haemaglobinopathies (e.g. sickle cell disease), pancreatitis, dysbaric conditions or trauma (e.g. dislocation or fracture).[0003]Osteonecrosis is characterized by distinct histopathological features apparent on radiographs or b...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61M36/00A61K31/28A61K31/56A61K31/57A61K31/663A61K45/06
CPCA61K31/28A61K31/56A61K31/57A61K31/663A61K33/24A61K45/06A61K2300/00A61P19/08A61P31/12
Inventor HANSEN, CHRISTIANNILSSON, HENRIKCHRISTGAU, STEPHANBONE, HENRY G.
Owner OSTEOLOGIX AS
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