Application of xylaria nigriper powder to preparation of medicines or healthcare food for preventing and treating osteoporosis and osteonecrosis

A technology for osteoporosis and health food, applied in the field of traditional Chinese medicine

Active Publication Date: 2016-10-12
雷允上药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report on the prevention and...

Method used

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  • Application of xylaria nigriper powder to preparation of medicines or healthcare food for preventing and treating osteoporosis and osteonecrosis
  • Application of xylaria nigriper powder to preparation of medicines or healthcare food for preventing and treating osteoporosis and osteonecrosis
  • Application of xylaria nigriper powder to preparation of medicines or healthcare food for preventing and treating osteoporosis and osteonecrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Pharmacodynamic Study on Osteoporosis Treated by Wulingjun Powder

[0026] 1 material

[0027] 1.1 Experimental animals

[0028] Wistar male rats, weighing 180-220 g.

[0029] 1.2 Drugs and reagents

[0030] Wuling mushroom powder: provided by Hangzhou Zhongzhi Kanggu Biotechnology Co., Ltd., batch number JC16011401. Positive drug: Gushukang Capsules, 0.32g / capsule, produced by Liaoning Kangchen Pharmaceutical Co., Ltd., batch number 150501. Retinoic acid tablets, 10mg / tablet, produced by Shandong Liangfu Pharmaceutical Co., Ltd., batch number 140230. The above medicines are prepared with distilled water to make a certain concentration for intragastric administration before use.

[0031] 1.3 Instruments and equipment

[0032] Atomic absorption spectrophotometer, single-photon bone mineral density tester, multifunctional true-color pathological image analyzer, electronic balance.

[0033] 2 Experimental methods

[0034] 2.1 Grouping and administration ...

Embodiment 2

[0053] Example 2 Pharmacodynamic study on prevention and treatment of steroid-induced necrosis of the femoral head by Wuling bacteria powder

[0054] 1. Materials

[0055] 1.1 Experimental animals

[0056] Wistar rat suckling mouse.

[0057] 1.2 Drugs and reagents

[0058] Wuling mushroom powder: provided by Hangzhou Zhongzhi Kanggu Biotechnology Co., Ltd., batch number JC16011401. Positive drug: Xianling Gubao capsule, 0.5g / capsule, Guizhou Tongjitang Pharmaceutical Co., Ltd., batch number 141203. Prednisone acetate tablets, 5mg / tablet, produced by Tianjin Pharmaceutical Group Xinzheng Co., Ltd., batch number 140516. The above medicines are prepared with distilled water to make a certain concentration for intragastric administration before use.

[0059] 2. Experimental method

[0060] Take Wistar rat suckling mice, half male and half male. It is randomly divided into 6 groups, 10 in every group, respectively blank control group, model group, positive control group (Xia...

Embodiment 3

[0070] Example 3 Pharmacodynamic study on prevention and treatment of alcoholic femoral head necrosis by Wuling bacteria powder

[0071] 1 material

[0072] 1.1 Experimental animals

[0073] 65 New Zealand male white rabbits aged 8-10 weeks in clean grade, body weight (2.5±0.5kg).

[0074] 1.2 Drugs and reagents

[0075] Wuling mushroom powder: provided by Hangzhou Zhongzhi Kanggu Biotechnology Co., Ltd., batch number JC16011401. Positive drug: Xianling Gubao capsule, 0.5g / capsule, Guizhou Tongjitang Pharmaceutical Co., Ltd., batch number 141203. The above medicines are prepared with distilled water to make a certain concentration for intragastric administration before use.

[0076] 2 Experimental methods

[0077] 8 mL / (kg·d) of strong liquor (containing 56% ethanol) was given by intragastric administration. After 4 weeks, 5 animals were randomly selected, and the pathological examination confirmed that the modeling was successful. The remaining 60 were randomly divided ...

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Abstract

The invention discloses application of xylaria nigriper powder to preparation of medicines or healthcare food for preventing and treating osteoporosis and osteonecrosis. According to animal pharmacological experiments, the xylaria nigriper powder is capable of increasing bone mineral density and bone calcium and phosphorus content of osteoporosis model rats and increasing bone mass to make bone tissue microstructures tend to be normal; the xylaria nigriper powder is also capable of remarkably increasing femoral head capillary distribution of steroid-induced femoral head necrosis model rats and reducing fat deposition in femoral head bone tissues of the steroid-induced femoral head necrosis model rats; the xylaria nigriper powder is capable of remarkably increasing bone trabecula area fraction of alcoholic femoral head necrosis model rats and remarkably reducing empty lacuna count to realize normal morphology of bone cells in bone lacunae. According to clinical researches, the xylaria nigriper powder has a remarkable treatment effect on osteoporosis, steroid-induced femoral head necrosis and alcoholic femoral head necrosis. The xylaria nigriper powder is reliable in curative effect and high in safety and has a promising clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and relates to a new application of Wuling bacteria powder, in particular to a new application of Wuling bacteria powder in preparing medicines and health food for preventing and treating osteoporosis and osteonecrosis. Background technique [0002] Osteoporosis (OP) is a common senile disease, because it often has no special clinical manifestations in the early stage, but it is more common in middle-aged and elderly people, so it is called "silent epidemic". sick". The definition of osteoporosis by the World Health Organization in 1994 is: a systemic bone disease characterized by low bone mass, destruction of bone microstructure, increased bone fragility, and prone to fractures. In 2001, the US NIH revised the definition of osteoporosis as: a bone disease with impaired bone strength and increased risk of fracture; bone strength is a comprehensive reflection of bone density...

Claims

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Application Information

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IPC IPC(8): A61K36/062A61P19/10A61P19/08A23L33/00A23L31/00A23L33/16A23L33/155
CPCA23V2002/00A61K36/062A23V2200/306
Inventor 王恒斌罗年翠李全张方宁叶华祝倩倩孙翔
Owner 雷允上药业集团有限公司
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