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Application of a traditional Chinese medicine composition in the preparation of medicines or health products for treating osteoporosis and osteonecrosis

An osteoporosis and composition technology, which is applied in the application field of medicine or health care products, can solve the problems of large side effects, unsatisfactory curative effect, long course of treatment, etc., and achieves the effects of small side effects, good clinical application prospect and good curative effect.

Active Publication Date: 2017-12-01
雷允上药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, for osteonecrosis, conservative treatment is mainly used in the early stage, and artificial replacement is used in the late stage, which has the disadvantages of high cost, long course of treatment, large side effects, and unsatisfactory curative effect.

Method used

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  • Application of a traditional Chinese medicine composition in the preparation of medicines or health products for treating osteoporosis and osteonecrosis
  • Application of a traditional Chinese medicine composition in the preparation of medicines or health products for treating osteoporosis and osteonecrosis
  • Application of a traditional Chinese medicine composition in the preparation of medicines or health products for treating osteoporosis and osteonecrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Pharmacodynamic study on the treatment of osteoporosis with the Chinese medicinal composition described in Example 1

[0033] 1. Materials

[0034] 1.1 Experimental animals

[0035] SD rats, weighing 180-220 g.

[0036] 1.2 Drugs and reagents

[0037] The traditional Chinese medicine composition capsule: Prescription: 90 parts of Radix Polygoni Multiflori, 90 parts of Polygonatum, 90 parts of Rehmannia glutinosa, 90 parts of Gorgon, 10 parts of Ziheche, 40 parts of black sesame, 90 parts of Astragalus, 90 parts of Poria cocos, 40 parts of Chinese yam, 14 parts of American ginseng, 40 parts of asparagus, 40 parts of Radix Ophiopogon, 3 parts of pearl, 7 parts of amber, 26 parts of keel, 40 parts of arborvitae leaves, and 90 parts of black soybean. Preparation method: ① Take the prescribed amount of American ginseng and extract it twice with 10 times of 70% ethanol, 1 hour each time, combine the extracts, filter, recover ethanol, concentrate into a clear paste, dry the...

Embodiment 2

[0056] Pharmacodynamic research on the treatment of steroid-induced necrosis of the femoral head by the Chinese medicine composition described in embodiment 2

[0057] 1. Materials

[0058] 1.1 Experimental animals

[0059] Wistar rat suckling mouse.

[0060] 1.2 Drugs and reagents

[0061] Prescription: Polygonum multiflorum 100 parts, Polygonatum 100 parts, Rehmannia glutinosa 100 parts, Gorgon fruit 100 parts, Ziheche 10 parts, Black sesame 50 parts, Astragalus 100 parts, Poria cocos 100 parts, Chinese yam 40 parts, American ginseng 18 parts, Asparagus 40 parts 60 parts of Ophiopogon japonicus, 3 parts of pearls, 8 parts of amber, 26 parts of keel, 40 parts of oriental cypress leaves, and 80 parts of black soybeans. Preparation method: ① Take the prescribed amount of American ginseng and extract it twice with 10 times of 70% ethanol, 1 hour each time, combine the extracts, filter, recover ethanol, concentrate into a clear paste, dry the residue of American ginseng, crush...

Embodiment 3

[0074] Clinical research on the treatment of osteoporosis with the Chinese medicine composition described in embodiment 3

[0075] 1 Materials and Standards

[0076] 1.1 General information: 90 patients with primary osteoporosis were selected, aged 45 to 75 years, with an average age of 61.5 years. There were 45 cases in the treatment group and 45 cases in the control group. There was no significant difference in age, gender, and dialectical classification between the two groups, and they were comparable.

[0077] 1.2 Inclusion criteria: ① Elderly age ≥ 60 years old, pre-senile age 45-59 years old. ② Meet the diagnostic criteria of osteoporosis in Western medicine: according to the "Recommended Diagnostic Criteria for Osteoporosis in China" passed in 1999. ③Complies with the diagnostic criteria of TCM syndromes: formulated with reference to the "Reference Standards for Dialectical Diagnosis of Deficiency Syndrome of Traditional Chinese Medicine" formulated by the Zhengzhou ...

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Abstract

The invention discloses an application of a traditional Chinese medicine composition in the preparation of medicines or health care products for treating osteoporosis and osteonecrosis. The traditional Chinese medicine composition of the present invention is made of Polygonum multiflorum, Polygonatum, Rehmannia glutinosa, Gorgon fruit, Ziheche, black sesame, Astragalus, Poria cocos, Chinese yam, American ginseng, Radix asparagus, Ophiopogon japonicus, pearl, amber, keel, arborvitae leaves, black soybean to make. Pharmacodynamic experiments show that the Chinese medicine composition of the present invention can increase the bone density of osteoporosis model rats and serum calcium and phosphorus levels; it can increase the distribution of capillaries in the femoral head of rats with steroid-induced necrosis of the femoral head, and reduce the distribution of steroid-induced necrosis of the femoral head model. Fat deposits in the femoral head bone tissue of rats, and clinical research results also show that the traditional Chinese medicine composition of the present invention has a good therapeutic effect on osteoporosis and femoral head necrosis. The traditional Chinese medicine composition provided by the invention has the advantages of good curative effect and small side effects in treating osteoporosis and osteonecrosis, and has good clinical application prospect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically relates to a Chinese herbal medicine containing Polygonum multiflorum, Polygonatum, Rehmannia glutinosa, Gorgon fruit, Ziheche, black sesame, Astragalus, Poria cocos, Chinese yam, American ginseng, Asparagus, Ophiopogon japonicus, pearl, amber, keel, side Application of the traditional Chinese medicine composition of cypress leaves and black soybeans in the preparation of medicines or health products for treating osteoporosis and osteonecrosis. Background technique [0002] Osteoporosis (OP) is a metabolic bone disease characterized by systemic osteopenia, loss of bone density, and destruction of bone microarchitecture, resulting in increased bone fragility and decreased bone strength prone to fracture. , shorter height, even spinal deformity, or fractures are the clinical manifestations, mainly pain symptoms, common in the lower back. According to the etio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8969A61P19/10A61P19/08A23L33/00A61K35/618A61K35/50A61K35/10A61K35/02
Inventor 王恒斌李全罗年翠王亦周叶华马鸣花祝倩倩孙翔
Owner 雷允上药业集团有限公司
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