A new type of bone regeneration-promoting material and preparation method thereof

A new type of nanosheet technology, which is applied in the fields of biomedical materials technology and biomedical engineering, can solve the problems of long degradation time, failure to meet the speed requirements of bone repair in the body, and failure of organic materials to achieve good biocompatibility.

Active Publication Date: 2021-11-19
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI +1
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AI Technical Summary

Problems solved by technology

Although artificially synthesized hydroxyapatite can well simulate the inorganic structure of natural bone, the degradation time of hydroxyapatite in the body is too long, which can last for several years, which is not conducive to bone formation.
In addition, the degradation rate of tricalcium phosphate in the body is too fast to effectively promote bone regeneration in the long term
After making tricalcium phosphate and hydroxyapatite as a composite, although the biodegradation rate of the composite has been improved to a certain extent, it is difficult to control the degradation rate of the material in vivo relatively accurately by existing methods
Biomaterials such as silk protein and chitosan can promote bone regeneration to a certain extent, but the degree of promoting bone regeneration is limited, and cannot meet the speed requirements of bone repair in the body. In addition, organic materials cannot be visualized under X-rays. It makes it difficult to observe whether the material in the osteonecrosis area is fully filled and in place by X-ray after operation
Magnesium-based materials, represented by high-purity magnesium, degrade too quickly in the body, and a certain amount of hydrogen gas is generated during the degradation of magnesium metal, which causes emphysema in the local and subcutaneous implants. Although the research on magnesium alloys has been in full swing in recent years , but whether it is calcium-based materials or magnesium-based materials, few researchers have studied their performance in promoting bone regeneration in osteonecrosis areas, and none of the above materials that promote bone regeneration can promote bone quality outside the material implantation site. The effect of increased density
Although studies in recent years have shown that magnesium ions within a certain concentration range have a clear bone regeneration effect, the current research on magnesium-based materials is non-injectable, which reduces their operability to a certain extent. , which is not conducive to the vigorous promotion of this material in clinical applications in the future

Method used

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  • A new type of bone regeneration-promoting material and preparation method thereof
  • A new type of bone regeneration-promoting material and preparation method thereof
  • A new type of bone regeneration-promoting material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 Bone regeneration material 1 preparation

[0053] Mg(NO 3 ) 2 ·6H 2O(Sigma-Aldrich 63084-500G-F), Al(NO 3 ) 3 9H 2 O (Sigma-Aldrich 229415-100G), Yb (NO 3 ) 3 ·5H 2 O (Sigma-Aldrich209147-10G) was weighed according to the molar ratio of 1mmol:1.5mmol:0.4mmol, and dissolved in deionized water. Under the protection of nitrogen, the above three were completely dissolved by mechanical stirring to form a stable and uniform solution of 10mL. Prepare 10mL of 1mM NaOH solution, fully dissolve it for later use; prepare 3% NaNO 3 , and make 10mL mixed solution with formamide according to the ratio of 3:7. The above Mg(NO 3 ) 2 ·6H 2 O, Al(NO 3 ) 3 9H 2 O,Yb(NO 3 ) 3 ·5H 2 O solution and NaOH solution were added dropwise to NaNO 3 In the formamide mixed solution, keep the pH at 9-10, and perform mechanical stirring for 10-15 minutes in an oil bath at 80° C. to 90° C. After the reaction was completed and the solution was cooled, the solution was tak...

Embodiment 2

[0054] Example 2 Preparation of bone regeneration material 2

[0055] Mg(NO 3 ) 2 ·6H 2 O, Al(NO 3 ) 3 9H 2 O,Yb(NO 3 ) 3 ·5H 2 O was weighed according to the molar ratio of 4mmol:0.4mmol:0.5mmol, and dissolved in deionized water. Under the protection of nitrogen, the above three were completely dissolved by mechanical stirring to form a stable and uniform solution of 10mL. Prepare 10mL of 1-1.5mM NaOH solution, fully dissolve it for later use; prepare 3%-5% NaNO 3 , and make 10mL mixed solution with formamide according to the ratio of 3:7. The above Mg(NO 3 ) 2 ·6H 2 O, Al(NO 3 ) 3 9H 2 O,Yb(NO 3 ) 3 ·5H 2 O solution and NaOH solution were added dropwise to NaNO 3 In the formamide mixed solution, keep the pH at 9-10, and perform mechanical stirring for 10-15 minutes in an oil bath at 80° C. to 90° C. After the reaction was completed and the solution was cooled, the solution was taken out and centrifuged, washed three times with a mixture of deionized water...

Embodiment 3

[0056] Embodiment 3 Bone regeneration material 3 preparation

[0057] Mg(NO 3 ) 2 ·6H 2 O, Al(NO 3 ) 3 9H 2 O,Yb(NO 3 ) 3 ·5H 2 O was weighed according to the molar ratio of 2mmol:0.8mmol:0.2mmol, and dissolved in deionized water. Under the protection of nitrogen, the above three were completely dissolved by mechanical stirring to form a stable and uniform solution of 10mL. Prepare 10mL of 1-1.5mM NaOH solution, fully dissolve it for later use; prepare 3%-5% NaNO 3 , and make 10mL mixed solution with formamide according to the ratio of 3:7. The above Mg(NO 3 ) 2 ·6H 2 O, Al(NO 3 ) 3 9H 2 O,Yb(NO 3 ) 3 ·5H 2 O solution and NaOH solution were added dropwise to NaNO 3 In the formamide mixed solution, keep the pH at 9-10, and perform mechanical stirring for 10-15 minutes in an oil bath at 80° C. to 90° C. After the reaction was completed and the solution was cooled, the solution was taken out and centrifuged, washed three times with a mixture of deionized water...

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Abstract

The invention discloses a novel LDH nanosheet material, AL / LDH material and a preparation method of the two materials and their application in preparing bone regeneration materials for treating femoral head necrosis, bone defect and / or osteoporosis. The LDH component prepared by the present invention is a Mg-Al-Yb monolayer hydroxide, and sodium alendronate is loaded on the surface of the LDH through the interaction of hydrophilic groups. LDH and AL / LDH are used to accelerate bone regeneration in the area of ​​osteonecrosis. While accelerating bone regeneration at the material implantation site, AL / LDH can also promote the increase of bone density outside the necrosis area. At present, the main method for the clinical treatment of early femoral head necrosis is: heart medullary decompression combined with bone transplantation, AL / LDH and LDH can be used as bone graft materials after heart medullary decompression, and, for patients with systemic osteoporosis In patients, the use of AL / LDH as material filling in necrotic areas can help improve the bone density of the whole body.

Description

technical field [0001] The invention relates to the fields of biomedical material technology and biomedical engineering, in particular to a novel material for promoting bone regeneration and a preparation method thereof. Background technique [0002] With the extension of human life and the change of travel mode, the incidence of critical bone defects (bone defects that the body cannot repair spontaneously) is increasing. The causes of critical bone defects include but are not limited to tumors, femoral head necrosis In the United States, there are as many as 600,000 patients with critical bone defects due to tumors and trauma every year. In addition, about 20,000 to 30,000 people are diagnosed with femoral head necrosis every year, and the incidence rate of non-traumatic femoral head necrosis is 1.91 / 100,000*years. If patients with femoral head necrosis do not receive effective intervention in the early stage, the femoral head will develop in sequence according to the cour...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/04A61L27/54A61L27/02
Inventor 梁瑞政王英杰翁习生卫敏边焱焱
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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