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External use medicament for treating fungal dermatopathy

A technology for fungal skin diseases and external medicines, applied in skin diseases, antifungal agents, medical preparations containing active ingredients, etc., can solve the problems of loss of curative effect, large side effects, slow onset of effect, etc., to achieve no toxic side effects, Gentle on the human body, high healing effect

Active Publication Date: 2009-07-08
重庆灵方生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many medicines and patented technologies for the treatment of fungal skin diseases, such as commercially available fungal skin medicines such as dacryline and ketoconazole, and the Chinese patent No. ZL 02178037.6 discloses an invention patent containing metronidazole, levamisole and compound ketoconazole Ointments are fungal skin ointments. These products are mainly composed of antibiotics, antifungal western medicines or hormones, and have serious side effects. If used for a long time, it will not only have adverse effects on the body, but also produce drug resistance and lose curative effect
In addition, there are also antifungal skin medicines made of pure Chinese medicines. These medicines take effect very slowly and are not very effective in treating fungal skin diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 ointment

[0016] (1) First decoct 500 grams of Phellodendron Phellodendri, 300 grams of Sophora Sophora, 300 grams of Cnidium Fructus, 300 grams of Kochia scoparia, and 1,000 grams of Chuanjiao with 40,000 grams of water for 3 hours to obtain a preliminary extract, and concentrate the preliminary extract to 6,000 grams , filter to obtain the final extract, add 600 grams of glycerin, 100 grams of emulsifier K12 (12 alkyl sodium sulfate) powder, stir and heat to 80 ° C in a vacuum emulsification pot; (2) p-chloro-m-xylenol (PCMX) 100 grams, 800 grams of dry ester, 300 grams of C16-18 alcohol, 200 grams of stearic acid, 400 grams of thickener DS6000 (polyethylene glycol distearate) in an auxiliary pot and heated and stirred to 80 ° C, fully stirred until completely Dissolve; (3) Add the solution obtained in step (2) into the solution obtained in step (1), homogenize for 10 minutes, and when cooled to 60°C, add 100 grams of menthol and 50 gr...

Embodiment 2

[0017] The preparation of embodiment 2 gel

[0018] (1) First, decoct 300 grams of Cortex Phellodendri, 400 grams of Sophora Sophora, 400 grams of Cnidium Fructus, 400 grams of Kochia scoparia, and 8,000 grams of Chuanjiao with 35,000 grams of water to obtain a preliminary extract, and concentrate the preliminary extract to 8,000 grams. , filter to obtain the final extract, add 50 grams of carbomer, stir and heat to 80-85 ° C in a vacuum emulsification pot, then add 35 grams of triethanolamine and stir in the pot; (2) p-chloro-m-xylenol ( PCMX) 50 grams, 1800 milliliters of ethanol are heated and stirred fully in the auxiliary pot until fully dissolved; (3) the solution obtained in step (2) is added to the solution obtained in step (1), homogenized for 5 to 10 minutes, stirred and cooled to obtain .

Embodiment 3

[0019] Embodiment 3 preparation of aqueous solution

[0020] (1) First, decoct 700 grams of Cortex Phellodendri, 200 grams of Sophora Sophorae, 200 grams of Cnidium Fructus, 400 grams of Kochia scoparia, and 1,200 grams of Chuanjiao with 50,000 grams of water for 4 hours to obtain a preliminary extract, and concentrate the preliminary extract to 7,000 grams , filter to obtain the final extract, add 200 grams of thickener AES (sodium fatty alcohol polyoxyethylene ether sulfate) and stir in a vacuum emulsification pot to heat to 83 ° C; (2) 150 grams of p-chloro-m-xylenol (PCMX) , 2,500 grams of isopropanol was heated and stirred in an auxiliary pot to 83°C, and fully stirred until completely dissolved; (3) Add the solution obtained in step (2) to the solution obtained in step (1), homogenize for 5 to 10 minutes, and cool to 60 At ~65°C, add 50 grams of menthol and 50 grams of azone and stir for 10 to 15 minutes until completely dissolved, and stir until cooled.

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PUM

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Abstract

The invention provides an external used medicine for dermatologic diseases, which is characterized in that phellodendron, lightyellow sophora root, common cnidium fruit, broom cypress fruit, pericarpium zanthoxyli and chloroxylenol are used as active medicine ingredients, and the invention is prepared by mixing the active medicine ingredients with assistant ingredients that are acceptable in preparing external used medicines, wherein, the weight proportions of the active medicine ingredients are as follow: 2-8 parts of phellodendron, 1-5 parts of lightyellow sophora root, 1-5 parts of common cnidium fruit, 1-5 parts of broom cypress fruit, 4-15 parts of pericarpium zanthoxyli and 0.1-5 parts of chloroxylenol. The medicine is a combination of traditional Chinese medicine and western medicine, with the sterilizing rate of over 99.9%, and can effectively sterilize diverse bacteria and fungi such as golden brown staphylococcus, colon bacillus, candida albicans, etc. The external used medicine has quick effect on dermatologic diseases, has high cure rate, few side effects and no drug resistance, and can cure both symptom and root diseases.

Description

technical field [0001] The invention relates to an external medicine for treating skin diseases, in particular to an external medicine for treating fungal skin diseases. Background technique [0002] Fungal dermatosis is a common skin disease. Due to environmental pollution, decreased body resistance, skin damage and other reasons, various pathogenic bacteria, especially fungi, can easily cause skin and mucous membrane infections, resulting in a variety of skin diseases, and the disease is stubborn, often repeated and protracted, and the course of the disease is long. If it is not prevented in time, pathogenic bacteria may enter the blood circulation system through skin tissue and cause deep tissue infection. Therefore, it is necessary to prevent and control skin pathogenic bacteria in time, effectively sterilize bacteria, and maintain good health. At present, there are many medicines and patented technologies for the treatment of fungal skin diseases, such as commercially...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61P17/00A61P31/10A61K31/045A61K31/055
Inventor 白涛唐京生
Owner 重庆灵方生物技术有限公司
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