Proguanil to treat skin/mucosal diseases

A proguanil, disease technology, applied in the field of external use proguanil composition, can solve problems such as complications

Inactive Publication Date: 2011-06-08
TOLMAR INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most candida infections are treatable and cause uncomfortable symptoms such as redness and itching, but i

Method used

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  • Proguanil to treat skin/mucosal diseases
  • Proguanil to treat skin/mucosal diseases
  • Proguanil to treat skin/mucosal diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0233] In the relevant microbiological research, the time kill assay was used, and Propionibacterium acnes ATCC 6919 was used as the antibacterial activity index of proguanil. Proguanil was dissolved in 100% diethylene glycol monoethyl ether (diethylene glycol monoethyl ether, DGME) as a stock solution, and an appropriate amount of stock solution was added to Mueller Hinton II liquid medium, so that the drug concentration obtained was 0.16 μg / ml, 1.6 μg / ml, 16 μg / ml and 160 μg / ml. A control group containing medium alone and a control group containing 10% DGME solvent were added to the vials to make a total test volume of 15 ml. At time zero, 100 μl of freshly grown P. acnes 6919 suspension was added to make the initial bacterial suspension at 10 7 and 10 8 Between CFU / ml. All the suspensions of the test group and the control group were cultured under anaerobic conditions at 35°C, and then aliquots of the suspensions of the test group and the control group were taken out at ...

Embodiment 2

[0242] A topical lotion containing proguanil (10 mg / g) was prepared with the following composition.

[0243]

[0244] The emulsifying wax, isopropyl myristate, and polysorbate 60 were melted at 75° C. to form an oil phase. Proguanil hydrochloride and propylene glycol were dissolved in water at 75°C, and the resulting solution was mixed with the above oil phase. The obtained emulsion was mixed uniformly and cooled to 30°C.

Embodiment 3

[0246] A topical cream containing proguanil (10 mg / g) was prepared with the following composition.

[0247]

[0248] Isopropyl myristate, polysorbate 60, emulsifying wax, and stearyl alcohol were melted at 75° C. to form an oil phase. Proguanil hydrochloride, propylene glycol and glycerin were dissolved in purified water at 75°C, and the resulting solution was mixed with the above oil phase. The obtained emulsion was mixed uniformly and cooled to 30°C.

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Abstract

Proguanil has been found to have rapid and effective killing activity against a variety of disease-causing micro organisms. For example, when applied topically, proguanil is particularly effective against Propionibacterium acnes, a bacteria that causes acne; Corynebacterium minutissimum, a bacteria that causes erythrasma, Gardnerella vaginalis, a bacteria that causes vaginosis; Trichomonas vaginalis, a protozoan that causes trichomoniasis and C. albicans, a fungus (a form of yeast).

Description

technical field [0001] The invention relates to an external proguanil composition and the application of proguanil in external administration. Background technique [0002] Acne is a chronic inflammation of the pilosebaceous unit associated with the face and trunk, usually occurring during adolescence, resulting from a complex interplay of androgens and bacteria. Each pilosebaceous unit is often affected by acne consisting of hypertrophic, lobar sebaceous glands, hair, and pilosebaceous ducts lined with stratified squamous epithelium. Although these units are found almost all over the surface of the human skin, the associated special type of sebaceous unit is mainly found on the face, chest and upper back. Although facial acne may persist well past puberty for some women, acne often begins at puberty when sebum production is markedly increased due to circulating androgen levels, when the sebaceous The condition is most severe when the sebaceous ducts are able to hold sebum...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/155A61P17/00
CPCA61K31/155A61K9/0034A61K9/122A61K9/0014A61P9/00A61P17/00Y02A50/30
Inventor 肯尼思·戈多夫斯基
Owner TOLMAR INC
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