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Preparation method of high-adhesiveness degradable fiber protein adhesive

A technology of fibrin and adhesives, applied in surgical adhesives, pharmaceutical formulations, applications, etc., can solve problems such as poor bonding strength, and achieve good physical properties, good biocompatibility, and high bonding strength

Pending Publication Date: 2019-10-25
袁斯曼
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Technical problem to be solved by the present invention: Aiming at the problem of poor bonding strength of existing fibrin adhesives, a preparation method of high-adhesion degradable fibrin adhesives is provided

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Mix Span-80 and Tween-20 evenly at a mass ratio of 1:1 to obtain an emulsifier. In parts by weight, weigh 30 parts of dextran, 1 part of emulsifier, and 1 part of 5% Glutaraldehyde solution, 100 parts of deionized water, mixed dextran and deionized water, stirred at a stirring speed of 300r / min for 5min to obtain a reaction solution, added an emulsifier to the reaction solution, and stirred at a stirring speed of 800r / min Stir at room temperature for 10 min at room temperature to obtain a reaction emulsion. Add a 5% glutaraldehyde solution to the reaction emulsion and stir for 1 h at a water bath temperature of 40°C to obtain a matrix liquid; in parts by weight, weigh Take 30 parts of polypropylene oxide diol, 50 parts of isophorone diisocyanate, 1 part of glucose, 1 part of dibutyltin dilaurate, 1 part of diethylene glycol, and 0.5 part of triethylamine. Mix propanediol, isophorone diisocyanate and glucose, and stir at a constant temperature of 80°C and a stirring spee...

Embodiment 2

[0033] Mix Span-80 and Tween-20 evenly at a mass ratio of 1:1 to obtain an emulsifier. In parts by weight, weigh 35 parts of dextran, 3 parts of emulsifier, and 2 parts of 5% Glutaraldehyde solution, 110 parts of deionized water, mixed dextran and deionized water, stirred at a stirring speed of 350r / min for 8min to obtain a reaction solution, added an emulsifier to the reaction solution, and stirred at a stirring speed of 900r / min Stir at room temperature for 12 min at room temperature to obtain a reaction emulsion. Add a 5% glutaraldehyde solution to the reaction emulsion and stir for 1 h at a water bath temperature of 45°C to obtain a matrix liquid; in parts by weight, weigh Get 35 parts of polypropylene oxide diol, 55 parts of isophorone diisocyanate, 5 parts of glucose, 3 parts of dibutyltin dilaurate, 2 parts of diethylene glycol, 0.6 part of triethylamine, polyepoxide Mix propanediol, isophorone diisocyanate and glucose, stir at a constant temperature of 85°C and a stirr...

Embodiment 3

[0035] Mix Span-80 and Tween-20 evenly at a mass ratio of 1:1 to obtain an emulsifier. In parts by weight, weigh 40 parts of dextran, 5 parts of emulsifier, and 3 parts of 5% Glutaraldehyde solution, 120 parts of deionized water, mixed dextran and deionized water, stirred at a stirring speed of 400r / min for 10min to obtain a reaction solution, added an emulsifier to the reaction solution, and stirred at a stirring speed of 1000r / min Stir at room temperature for 15 min at room temperature to obtain a reaction emulsion. Add a 5% glutaraldehyde solution to the reaction emulsion and stir for 2 hours at a water bath temperature of 50°C to obtain a matrix liquid; in parts by weight, weigh Take 40 parts of polypropylene oxide diol, 60 parts of isophorone diisocyanate, 10 parts of glucose, 5 parts of dibutyltin dilaurate, 3 parts of diethylene glycol, and 0.7 part of triethylamine. Mix propanediol, isophorone diisocyanate and glucose, stir at a constant temperature of 90°C and a stirr...

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Abstract

The invention belongs to the technical field of adhesive materials and relates to a preparation method of a high-adhesiveness degradable fiber protein adhesive. The high-adhesiveness degradable fiberprotein adhesive is prepared by adopting glutaraldehyde as a cross-linking agent for cross linking with glucan molecules, adopting fibrin glue as a raw material and adopting glucose modified polyurethane as an adhesive. The hydroxyl-containing glucan molecules are available for direct reaction with glutaraldehyde under violent reaction conditions, and by cross linking of hydroxyl and formyl, the prepared high-adhesiveness degradable fiber protein adhesive can be quickly polymerized to realize form adhesion while degradability is realized; by adoption of glucose for modification of polyurethanewith unique advantages of high bonding strength, resistance to water, solvents and low temperature, availability for low-temperature curing and the like, polyurethane is endowed with high degradability. Therefore, high bonding strength and a soft-hard transition layer with great physical properties can be formed between substrates by the prepared high-adhesiveness degradable fiber protein adhesive.

Description

technical field [0001] The invention relates to a preparation method of a highly adhesive and degradable fibrin adhesive, which belongs to the technical field of adhesive materials. Background technique [0002] Medical tissue adhesive is a new type of medical material, which has the functions of bonding, hemostasis and filling tissue defects. There are many kinds of medical adhesives, which can be divided into chemical adhesives and biological adhesives according to the properties of the main components, and biological adhesives include mussel protein adhesives and fibrin adhesives. Among them, fibrin adhesive is a kind of biological adhesive, which is composed of various components such as fibrinogen, factor XIII, thrombin, aprotinin and calcium chloride, and is artificially completed in the final stage of the blood coagulation process. , form a stable fibrin polymer, so as to achieve the effect of tissue sealing, hemostasis and tissue adhesion, and can be used for hemost...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/10A61L24/00
CPCA61L24/0015A61L24/0042A61L24/043A61L2300/232A61L2300/236A61L2300/42A61L2300/422A61L2400/04C08L5/02C08L89/00
Inventor 袁斯曼
Owner 袁斯曼
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