Preparation method of high-adhesiveness degradable fiber protein adhesive

Abstract

The invention belongs to the technical field of adhesive materials and relates to a preparation method of a high-adhesiveness degradable fiber protein adhesive. The high-adhesiveness degradable fiberprotein adhesive is prepared by adopting glutaraldehyde as a cross-linking agent for cross linking with glucan molecules, adopting fibrin glue as a raw material and adopting glucose modified polyurethane as an adhesive. The hydroxyl-containing glucan molecules are available for direct reaction with glutaraldehyde under violent reaction conditions, and by cross linking of hydroxyl and formyl, the prepared high-adhesiveness degradable fiber protein adhesive can be quickly polymerized to realize form adhesion while degradability is realized; by adoption of glucose for modification of polyurethanewith unique advantages of high bonding strength, resistance to water, solvents and low temperature, availability for low-temperature curing and the like, polyurethane is endowed with high degradability. Therefore, high bonding strength and a soft-hard transition layer with great physical properties can be formed between substrates by the prepared high-adhesiveness degradable fiber protein adhesive.

Description

technical field

[0001] The invention relates to a preparation method of a highly adhesive and degradable fibrin adhesive, which belongs to the technical field of adhesive materials. Background technique

[0002] Medical tissue adhesive is a new type of medical material, which has the functions of bonding, hemostasis and filling tissue defects. There are many kinds of medical adhesives, which can be divided into chemical adhesives and biological adhesives according to the properties of the main components, and biological adhesives include mussel protein adhesives and fibrin adhesives. Among them, fibrin adhesive is a kind of biological adhesive, which is composed of various components such as fibrinogen, factor XIII, thrombin, aprotinin and calcium chloride, and is artificially completed in the final stage of the blood coagulation process. , form a stable fibrin polymer, so as to achieve the effect of tissue sealing, hemostasis and tissue adhesion, and can be used for hemost...