Preparation method of transdermal drug delivery system (TDDS)

A drug delivery system and drug technology, applied in the field of medicine, can solve the problems of small molecule compounds easily entering the human body through the skin, allergic reactions, etc., and achieve the effect of easy operation, simple steps, and high transmittance

Inactive Publication Date: 2013-08-07
SHANGHAI MEDICAL INSTR COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current transdermal drug delivery system generally consists of adhesives, small molecule accelerators and drugs, and there is a problem of drug release control. In the process of mixing with drugs, there is a corresponding relationship between ionic and insoluble drugs, and small molecule compounds Easy to enter the human body through the skin, causing allergic reactions

Method used

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  • Preparation method of transdermal drug delivery system (TDDS)
  • Preparation method of transdermal drug delivery system (TDDS)
  • Preparation method of transdermal drug delivery system (TDDS)

Examples

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Embodiment 1

[0026] This embodiment relates to a preparation method of a transdermal drug delivery system, comprising the following steps:

[0027] Step 1: Add 200 mg of medium-chain PHA synthesized by Pseudomonas putida KT2442 into 1 ml of chloroform solution and mix to obtain solution A;

[0028] Step 2, add 2.5 mg of anionic drug to 1 ml of dimethyl sulfoxide solution and mix to obtain solution B;

[0029] In step 3, 50 μL of solution A and 50 μL of solution B were evenly mixed, coated on cellophane, and dried to obtain the final transdermal drug delivery system.

[0030] Implementation effect: see figure 2 shown.

Embodiment 2

[0032] This embodiment relates to a preparation method of a transdermal drug delivery system, comprising the following steps:

[0033] Step 1: Add 200 mg of medium-chain PHA synthesized by Pseudomonas putida KT2442 into 1 ml of chloroform solution and mix to obtain solution A;

[0034] Step 2, add 2.5 mg of anionic drug to 1 ml of dimethyl sulfoxide solution and mix to obtain solution B;

[0035] In step 3, 60 μL of solution A and 60 μL of solution B were evenly mixed, coated on cellophane, and dried to obtain the final transdermal drug delivery system.

[0036] Implementation effect: see image 3 shown.

Embodiment 3

[0038] This embodiment relates to a preparation method of a transdermal drug delivery system, comprising the following steps:

[0039] Step 1: Add 200 mg of medium-chain PHA synthesized by Pseudomonas putida KT2442 into 1 ml of chloroform solution and mix to obtain solution A;

[0040] Step 2, add 2.5 mg of anionic drug to 1 ml of dimethyl sulfoxide solution and mix to obtain solution B;

[0041] In step 3, 70 μL of solution A and 70 μL of solution B were evenly mixed, coated on cellophane, and dried to obtain the final transdermal drug delivery system.

[0042] Implementation effect: see Figure 4 shown.

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Abstract

The invention provides a preparation method of a transdermal drug delivery system (TDDS). The preparation method comprises the following steps that 1. adding midchain PHA (polyhydroxyalkanoate) to chloroform solution to be mixed to obtain solution A; 2. adding drugs to dimethyl sulfoxide solution to be mixed to obtain solution B; and 3. mixing the solution A with the solution B uniformly, then coating the mixture on glass paper and drying the glass paper, thus obtaining the final product, namely the TDDS. The preparation method has the beneficial effects that the biodegradable material PHA obtained by synthesizing microorganisms is utilized as one of the raw materials and can replace adhesives and micromolecular accelerants in the existing TDDSs; PHA is combined with ionic and insoluble drugs respectively by utilizing the physiochemical properties of PHA, thus forming the TDDS; with slow release property, PHA can control drug release; and the TDDS has high transmittance, obvious effects, simple steps and better application prospect and is easy to operate.

Description

technical field [0001] The invention relates to a preparation method in the field of medicine, in particular to a preparation method of a transdermal drug delivery system. Background technique [0002] The transdermal drug delivery system means that the drug passes through the stratum corneum at a constant speed (or close to the constant speed), is absorbed through the skin, is absorbed into the blood circulation of the whole body by the capillary, reaches an effective blood drug concentration, and is efficiently transferred to the target tissue , to achieve the purpose of disease treatment or prevention, is a new way of drug delivery. [0003] The current transdermal drug delivery system generally consists of adhesives, small molecule accelerators and drugs, and there is a problem of drug release control. In the process of mixing with drugs, there is a corresponding relationship between ionic and insoluble drugs, and small molecule compounds It is easy to enter the human b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/42A61K45/00
Inventor 王志雄
Owner SHANGHAI MEDICAL INSTR COLLEGE
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