Novel biodegradable zinc-based metal material and ureteral expandable stent obtained through material

A base metal and ureter technology, applied in the field of ureteral expansion stents, can solve the problems of difficulty in meeting the requirements of ureteral expansion stents, slow healing of ureteral inner wall tissue, and easy inflammation caused by degradation products, achieving controllable mechanical properties and corrosion properties, and easy adhesion. Attached to the effect of repairing growth and good developability

Active Publication Date: 2016-09-07
管仁国
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the materials used to make biodegradable ureteral expansion stents are mainly biodegradable polymer materials and biodegradable magnesium-based metal materials, but the mechanical properties of the former are poor, and their degradation products are easy to cause inflammation, leading to the healing of the inner wall of the ureter Slow; the corrosion rate of the latter is too fast in the acidic environment of the ureter, resulting in premature degradation in the human body, making it difficult to meet the requirements of ureteral expansion stents

Method used

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  • Novel biodegradable zinc-based metal material and ureteral expandable stent obtained through material
  • Novel biodegradable zinc-based metal material and ureteral expandable stent obtained through material
  • Novel biodegradable zinc-based metal material and ureteral expandable stent obtained through material

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Experimental program
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Effect test

Embodiment 1

[0031] A new type of biodegradable zinc-based metal material for ureteral expansion stent, which is composed of Zn, and is prepared from high-purity zinc (≥99.995%). The photo of the metallographic structure of the scaffold material is attached figure 1 shown. The test results of the mechanical properties of the material show that its tensile strength is between 160MPa and 180MPa, and the maximum elongation at room temperature is between 40% and 50%. Therefore, the ureter expansion stent prepared by the material has excellent toughness and deformation ability.

[0032]The stent is composed of wire rods spirally coiled and is in the shape of a dumbbell with both ends enlarged and the middle section is slender. The diameter of the wire rod is 0.1 mm, the middle section 2 of the stent is 20 mm long, and the inner diameter is 2 mm; 120%, the length is 5mm; the pitch of the wire coil is 1mm.

[0033] After a 30-day in vitro degradation test in simulated urine, it was found that ...

Embodiment 2

[0035] A new type of biodegradable zinc-based metal material for ureteral expansion stents, all made of the same zinc alloy, the mass percentage of the zinc alloy is composed of Mg: 0.5%, Cu: 3%, Nd: 0.5%, and the balance is Zn. High-purity zinc (≥99.99 wt.%), high-purity magnesium (≥99.99 wt.%), high-purity copper (≥99.99 wt.%) and high-purity neodymium (≥99.95 wt.%) are used as raw materials. The mechanical performance test results of the material show that its tensile strength is between 330MPa-360MPa, and the maximum elongation at room temperature is between 20%-30%. It can be seen that the ureteral expansion stent made of this material has excellent strength and support performance.

[0036] The stent is composed of intersecting wire rods and is in the shape of a mesh dumbbell with enlarged ends and a slender middle section. The diameter of the wire rod is 0.2 mm, the middle section 2 of the stent is 40 mm long, and the inner diameter is 3 mm; the inner diameter of the e...

Embodiment 3

[0039] A new type of biodegradable zinc-based metal material for ureteral expansion stent, the surface material is zinc alloy, and its mass percentage is Ag: 1.0%, Gd: 2%, and the balance is Zn. The core material is zinc alloy, and its mass percentage is composed of Al: 4%, Ti: 0.1%, and the balance is Zn. The thickness ratio of surface layer material to core material is 4:6. High-purity zinc (≥99.99 wt.%), high-purity silver (≥99.99 wt.%), high-purity gadolinium (≥99.95 wt.%), high-purity aluminum (≥99.99 wt.%), high-purity titanium (≥99.99 wt.%) .%) is prepared from raw materials. The mechanical performance test results of the material show that its tensile strength is between 280MPa-320MPa, and the maximum elongation at room temperature is between 30%-40%. Therefore, the ureter expansion stent prepared by this material has excellent strength and support performance.

[0040] The stent is composed of intersecting wires and is in the shape of a mesh dumbbell with both ends...

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Abstract

The invention belongs to the field of medical implant materials and particularly relates to a novel biodegradable zinc-based metal material and a ureteral expandable stent obtained through the material. The zinc-based metal material is composed of zinc and/or zinc alloy. The zinc alloy is composed of Zn and one or more elements of Mg, Al, Ti, Cu, Ag, Si, Ca, Sr, Y, Zr, Sc, Gd, Nd, Dy, Er, Li, Mn, La, Ce, Pr, Sm, Tb, Ho, Tm, Yb and Lu. The biodegradable zinc-based metal material has good biocompatibility, degradability and mechanical properties, and has wide market application prospects.

Description

technical field [0001] The invention belongs to the field of medical implant materials, in particular to a novel biodegradable zinc-based metal material and a ureter expansion bracket obtained by using the material. Background technique [0002] In the practice of urology, ureteral expansion stent is a commonly used medical device, which is mainly used to treat or relieve symptoms of ureteral obstruction, including urolithiasis, ureteral stricture, ureteral obstruction, ureteropelvic junction obstruction and retroperitoneal tumor or fibrosis Wait. Clinically, it is mainly placed at the obstructed or stenotic ureter, so as to expand the obstruction or stenosis, so that urine can flow into the bladder smoothly, and promote the healing of the ureteral anastomosis while reducing renal or ureteral fistula. [0003] Currently, ureteral expansion stents commonly used in clinical practice are mainly divided into two categories: metal and polymer; according to whether the material c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C18/00C22C18/02C22C18/04C22C30/06A61L31/02A61L31/08A61L31/14A61L31/18A61F2/90
CPCA61F2/90A61L31/022A61L31/082A61L31/148A61L31/18C22C18/00C22C18/02C22C18/04C22C30/02C22C30/06
Inventor 管仁国刘屹立王宇翔
Owner 管仁国
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