38results about How to "Does not cause infection" patented technology

The invention belongs to the field of medical implant materials and particularly relates to a novel biodegradable zinc-based metal material and a ureteral expandable stent obtained through the material. The zinc-based metal material is composed of zinc and / or zinc alloy. The zinc alloy is composed of Zn and one or more elements of Mg, Al, Ti, Cu, Ag, Si, Ca, Sr, Y, Zr, Sc, Gd, Nd, Dy, Er, Li, Mn, La, Ce, Pr, Sm, Tb, Ho, Tm, Yb and Lu. The biodegradable zinc-based metal material has good biocompatibility, degradability and mechanical properties, and has wide market application prospects.

The invention relates to the technical field of microfluidic chip chemiluminescent immunoassay, in particular to a chemiluminescent detection microfluidic chip and a chemiluminescent detection microfluidic chip system and application thereof. The chemiluminescent detection microfluidic chip comprises a sample feeding unit (1), a liquid storage unit (2), a reaction unit (3) and a waste liquid unit(4), and further comprises a quantifying unit (5) for quantifying a sample to be detected, wherein the quantifying unit (5) comprises a liquid inlet (51) connected with the sample feeding unit, a liquid outlet (52) connected with the waste liquid unit, a quantifying structure (53) for quantifying, and a temporary storage structure (54) for temporarily storing excess liquid, which is connected withthe reaction unit. The chemiluminescent detection microfluidic chip system consists of three layers, namely an upper layer, a middle layer and a lower layer; the middle layer is the chip; the upper layer and the lower layer are used for closing the middle layer; the upper layer is provided with a sample feeding hole connected with the sample feeding unit and a yielding hole corresponding to the liquid storage unit. The chemiluminescent detection microfluidic chip is simple in detection process, can quantify the reaction sample and has high sensitivity and strong repeatability.

The invention relates to the field of micro-fluidic chip molecular diagnosis, and in particular to a molecular diagnosis micro-fluidic chip, a molecular diagnosis micro-fluidic chip system and applications of the molecular diagnosis micro-fluidic chip and the molecular diagnosis micro-fluidic chip system. The chip comprises a sample injection unit (1) which is used for receiving to-be-detected samples, at least one liquid storage unit (2) for storing reaction reagents, a cell lysis unit (3) for conducting cell lysis and a nucleic acid amplification unit (4) for conducting nucleic acid amplification, wherein the cell lysis unit comprises a slit (31) as well as a first compartment (32) and a second compartment (33) which are separated by virtue of the slit; at least one compartment is configured with grinding micro-beads; the first compartment communicates with the sample injection unit; and the second compartment communicates with the at least one liquid storage unit, so as to receive acell lysis solution. The chip system is composed of three layers, namely an upper layer, a middle layer and a lower layer, wherein the chip is arranged on the middle layer; the upper and lower layersare used for covering and sealing the middle layer; the upper layer is provided with a sample injection hole which is connected to the sample injection unit, and the sample injection hole correspondsto an avoiding hole of the liquid storage unit. The chip is simple in detection process, high in sensitivity and strong in repeatability, and reaction samples can be quantified.

The invention relates to the technical field of biochemical detection of micro-fluidic chips and in particular relates to a biochemical detection micro-fluidic chip, a biochemical detection micro-fluidic chip system and applications thereof. The chip comprises a sampling unit (1), a reaction unit (3) and a waste liquid unit (4) and a first quantifying unit (5); the first quantifying unit (5) is used for quantifying a to-be-detected sample and is composed of a first slit (51) as well as a first sample chamber (52) and a second sample chamber (53) which are separated by the first slit (51); thefirst sample chamber communicates with the sampling unit, and the second sample chamber communicates with the waste liquid unit; and a third error reporting unit (14) is arranged between the reactionunit and the waste liquid unit and is provided with a chamber for receiving the to-be-detected sample from the reaction unit. The chip system is composed of three layers including an upper layer, a middle layer and a lower layer; the middle layer is the chip; the upper layer and the lower layer are used for covering and sealing the middle layer; and a sampling hole connected with the sampling unitand a demising hole corresponding to a liquid storage unit are formed in the upper layer. The chip is simple in detection process, capable of quantifying a reaction sample, high in sensitivity and strong in repeatability.

A minimally invasive, dynamic and continuous detection method for human blood glucose concentration, including: firstly, using low-frequency ultrasound for the pretreatment on skin; secondly, extracting human tissue fluid from the skin after the low-frequency ultrasound pretreatment under the vacuum negative function; thirdly, detecting the skin impedance / resistance during the permeable skin tissue liquid extraction process; fourthly, measuring the glucose concentration of the extracted human tissue liquid; fifthly, using the skin impedance / resistance to determine the extracted tissue liquid volume and to establish the prediction model of the correlation between the glucose concentration in the tissue liquid and the glucose concentration in blood; sixthly, obtaining the human blood glucose concentration according to the skin impedance / resistance that is measured in the third step, the glucose concentration of the human tissue liquid that is measured in the fourth step and the prediction model that is established in the fifth step. The invention can realize the minimally invasive, dynamic and continuous detection method for the human blood glucose concentration and has the advantages of high measurement resolution and precision, good stability of the measured result, small tissue liquid amount to be measured, rapid measuring speed, etc.

The invention relates to a disinfection device, and especially relates to an inner barrel disinfection device for a washing machine. The invention provides an inner barrel disinfection device for a washing machine, which is time-saving and labor-saving and low in labor strength, disinfection is comprehensive, fungal infection can be prevented, and furthermore various skin diseases can be prevented. Accordingly, the invention provides the inner barrel disinfection device for the washing machine, and the inner barrel disinfection device comprises a base plate, a disposing plate, a vertical plate, a cylinder, arc-shaped clamping plates, supporting plates, a top plate, a hollow sleeve, a first spring, a slide bar, an arc-shaped brush, and a first disinfection apparatus; and the middle of the top of the base plate is provided with a rotating apparatus, a rotating part of the rotating apparatus is connected with the disposing plate, and the vertical plate is installed at the middle of the top of the disposing plate in a bolt connection manner. The effects that time and labor are saved, labor strength is low, disinfection is comprehensive, fungal infection can be prevented, and furthermore various skin diseases can be prevented are achieved.

The invention discloses a medical hemostatic sponge material and a preparation method thereof. The preparation method comprises the following steps: S1, preparing materials; to be specific, dissolvingpolyvinyl alcohol in water to obtain a polyvinyl alcohol aqueous solution; S2, adding a catalyst and a cross-linking agent into the polyvinyl alcohol aqueous solution and making a reaction for 15 to25 minutes; and S3, adding porous starch, making a stirring reaction at a temperature of 60 to 65 DEG C and a rotating speed of 800 to 1000 rpm, and carrying out curing to obtain hemostatic sponge. The porous starch is obtained by conducting pre-gelatinization on potato starch and cassava starch to obtain a starch paste and then carrying out enzymolysis on the starch paste by using saccharifying enzyme liquid. According to the invention, the obtained hemostatic sponge material has advantages of being high in liquid absorption rate, good in hemostatic effect and is capable of being used for massive hemorrhage with high safety and efficiency.

The invention relates to a preparation method for a medical hemostasis hydrogel dressing. Human-like collagen (LHC) is dissolved into ultrapure water to prepare a protein solution, inorganic salt and a compound cross linker [beta]-diimine zinc complex and 1,2,7,8-diepoxy octane are added, the solution PH value is adjusted to 2-5.5, a mixed solution is placed into a water bath which is at the temperature of 40-80 DEG C to keep for 0.5-5 h after being stirred evenly, then the mixed solution is sequentially subjected to twice high-temperature vapor treatment and washing and finally subjected to drying treatment and Co-60 irradiation sterilization, and the novel sterile medical hemostasis hydrogel dressing can be obtained. According to the prepared medical hemostasis hydrogel dressing, the air permeability is good, the anti-microbial property is achieved, and wound infection cannot be caused; and the hemostatic time can be obviously shortened, a hemostatic material cannot adhere to a wound after hemostasis is completed, and the pain of a patient is obviously relieved.

The invention relates to a cervical cancer therapeutic vaccine based on recombinant attenuating sheep listeria ivanovii. By taking the attenuating sheep listeria ivanovii as a vector, specific immuneresponse in a tumor microenvironment is improved effectively and immune tolerance of a body is broken by means of a unique characteristic that the listeria ivanovii can grow in a main phagocyte and isa natural T cell immune activation adjuvant, so that continuous virus infection of the body is eliminated and the good therapeutic effect of eliminating the focus and inhibiting tumor development isachieved. The vaccine has the advantages that the defect that nucleic acid and protein polypeptide vaccines are relatively low in immunogenicity is made up, and the attenuating sheep listeria ivanoviialso has high safety while retaining the characteristic that an original strain can grow in cells to achieve antigen presentation.

The invention provides a preparation of stem cell active factor freeze-dried powder combined with traditional Chinese medicine for the treatment of mild to moderate acne and a preparation method of the preparation, and relates to the field of stem cell preparations and application of traditional Chinese medicine. The problem of poor effect of existing preparations for acne treatment is solved. Thepreparation is prepared from the stem cell active factor freeze-dried powder, a honeysuckle extracting solution and mixed traditional Chinese medicine powder; the mixed traditional Chinese medicine powder is prepared from scutellaria baicalensis georgi, angelica dahurica, rhizoma typhonii, radix sileris, salviae miltiorrhizae and mung beans. The preparation method includes the steps that umbilical cord and adipose derived mesenchymal stem cells are taken and mixed and cultured, and supernatants of P3, P4, P5 and P6 cells are obtained; the supernatants of the P3, P4, P5 and P6 cells are mixedand filtered, mannitol is added, sub-packaging and precooling are performed, and the freeze-dried powder is prepared; the honeysuckle extracting solution is prepared; and the mixed traditional Chinesemedicine powder is prepared. The preparation has a good effect on treating the mild to moderate acne, is not easy to produce dependence, acne marks can be eliminated or the production of acne and whelk can be inhibited, and the occurrence of fine wrinkles can be reduced and inhibited. The preparation method is simple and easy to operate, low in cost, and has non-toxic side effects. The preparation prepared by the method is used for treating the mild to moderate acne.

The invention relates to a cervical cancer therapeutic vaccine based on recombinant attenuated Listeria monocytogenes. Attenuated Listeria monocytogenes (hereinafter referred to as Lm) is used as a vector, and the unique ability of Listeria to grow in a host phagocytic cell is the characteristic of a natural T cell immune activation adjuvant, and is used to effectively improve the specific immuneresponse in a tumor microenvironment and break the immune tolerance of bodies, so persistent viral infection of the bodies is removed, and good therapeutic effects of clearing focus and restraining tumor development are achieved. The cervical cancer therapeutic vaccine makes up for the shortcoming of low immunogenicity of nucleic acid and protein peptide vaccines, and the attenuated Listeria reserves the intracellular growth and antigen presentation completion characteristics of an original strain, and has a high safety.

The invention relates to application of recombinant attenuated listeria in the preparation of a mesothelin high-expression cancer therapeutic vaccine. By taking attenuated Listeria monocytogenes (Lm for short hereinafter) and attenuated Listeria ivanovii (Li for short hereinafter) as carriers, and special listeria can grow in phagocyte of a host and is a natural T-cell immune activation adjuvant,so that the specific immune response in a tumor microenvironment is effectively improved, the immune tolerance of a body is broken through, the continuous virus infection of the body is eliminated, and good treatment effects on the elimination of an infection focus and the containment of tumor development are achieved. The application has the advantages that the disadvantages that nucleic acid type vaccines and protein polypeptide type vaccines are relatively low in immunogenicity are remedied, the attenuated listeria preserves the properties that an original strain can grow in the cells and finish antigen presentation, and meanwhile, the attenuated listeria has relatively high safety.

The invention relates to application of recombinant attenuated Listeria in preparation of a therapeutic vaccine for cervical cancer. Attenuated Listeria monocytogenes (hereinafter referred to as Lm) and attenuated Listeria ivanovii (hereinafter referred to as Li) are used as vectors, by use of the unique characteristic that the Listeria can grow in phagocytose cells in a host, and is a natural T cell immune activation adjuvant, specific immune response in tumor microenvironment can be effectively enhanced, body's immune tolerance can be broken, body's persistent viral infection can be eliminated, and good treatment results of clearing focuses and curbing tumor development can be achieved. The Listeria has the advantages that shortcomings of low immunogenicity of nucleic acid and protein peptide vaccines can be made up, the attenuated Listeria retains the characteristic that an attenuated original strain can grow intracellularly to complete antigen presentation, and meanwhile the attenuated Listeria has higher safety.

The invention relates to a paste-liquid double-dosage-form cooperatively-used drug for treating plantar warts and periungual warts and a preparation method of the drug, solving the problem that a drug in the prior art is slow in effect and causes infection. Eleven traditional Chinese medicines, including, according to a weight ratio, 6-21 of isatis roots, 2-7 of safflowers, 5-15 of lightyellow sophora roots, 2-7 of rhizoma curcumae, 5-15 of cortex dictamni, 5-15 of belvedere fruits, 6-21 of rhizoma cyperi, 20-40 of common scouring rush herbs, 20-40 of purslane herbs, 5-15 of peach seeds, and 20-40 of radix arnebiae are used to prepare a small part of fine mixed powder and a large part of coarse mixed powder, wherein the fine mixed powder cooperates with ass hide glue and urea to prepare paste, and the coarse mixed powder is extracted with colored vinegar to make a liquid. The paste is made by melting ass hide glue powder with water, cooling the obtained product till the product can be touched with hands and doesn't burn hands, adding finely-ground urea, adding the fine mixed powder till the temperature of the obtained product is reduced to the room temperature, and performing uniform mixing. The liquid is obtained by soaking the coarse mixed powder with colored vinegar and performing filtering. The drug has a quick effect, doesn't cause infection, allows warts not to relapse, can repair the damage due to holes of warts and damaged cells, and can remove warts without leaving scars.

The invention relates to a mesothelin high-expression cancer treatment vaccine based on recombinant attenuated listeria monocytogenes. The attenuated listeria monocytogenes (Lm) is used as a carier, the characteristics that the Lm can specifically grow in a host phagocyte and is a natural T cell immune activated reagent are utilized, specific immune response in a tumor microenvironment can be effectively improved, the immune tolerance of a body can be broken, persistent viral infection of the body can be cleaned, and an excellent treatment effect for cleaning the focus and inhibiting tumor development can be achieved. The mesothelin high-expression cancer treatment vaccine has the advantages of overcoming the defect of relatively low immunogenicity of nucleotide and protein polypeptide vaccines, the attenuated listeria remained with original strains can grow in cells, so that higher safety is achieved while the characteristic of antigen presentation can be completed.

The invention discloses a KRAS high-expression cancer vaccine based on recombinant attenuated Listeria monocytogenes and a preparation method and application method thereof. The cancer vaccine is bacterial liquid of an Lm delta actA / plcB-KRAS strain; the Lm delta actA / plcB-KRAS strain is a gene recombinant bacterium carrying a KRAS protein gene by taking the attenuated Listeria monocytogenes asa carrier; the attenuated Listeria monocytogenes is obtained by completely knocking out two virulence genes of actA and plcB from the Listeria monocytogenes; and the KRAS protein gene is a DNA sequence obtained by synthesizing a KRAS protein amino acid sequence after being optimized by a Listeria codon, adding a Hind III restriction enzyme cutting site at the upstream and adding an Xho I restriction enzyme cutting site at the downstream. According to the KRAS high-expression cancer vaccine disclosed by the invention, the attenuated Listeria monocytogenes is used as the carrier, and the specific immune response in a tumor microenvironment is effectively improved by utilizing the characteristic that the Listeria monocytogenes can uniquely grow in a host phagocyte and is a natural T cell immune activation adjuvant, so that the immune tolerance of an organism is broken, and further the development of tumors can be inhibited.

The invention provides an autologous concentrated growth factor implant surface fusion device and method, relates to the field of oral implantation, and solves the technical problem of rejection reaction during implantation due to individual difference in existing implant surface treatment. The device comprises a tubular bottle body, wherein a bottom seal and an upper cover are respectively arranged at two open ends of the bottle body; the bottom seal is made of an elastic material; the upper cover is detachably arranged on the bottle body; and a built-in converter can be adaptively connectedwith a carrier of an implant. When the upper cover connected with the implant is mounted back to the bottle body, the implant is immersed in autologous blood, and the fusion device is placed on a centrifuge to separate out autologous concentrated growth factors; and the implant is immersed in the high-concentration growth factors, and the concentrated growth factors are attached to gaps in the surface of the implant to form an autologous surface, so that the fusion and reforming of the implant and bones are accelerated, the rejection reaction during foreign matter implantation is reduced, andthe survival rate of the implant is increased.

The invention belongs to the field of hair dressing articles and particularly relates to a manufacturing method for a hand hook hair extension bundle. The manufacturing method includes the following steps: (1) thread folding which includes folding a cotton thread into two threads and making a knot at one thread end; (2) fixing which includes fixing the cotton thread on a head mould through two pins; (3) hair hooking which includes hooking hair on the cotton thread through a crochet hook; (4) knot tying which includes taking off the cotton thread after hair hooking and tying the end with the knot and the end with a folding mark to enable the hair hooking portion to form a ring; (5) sleeving of a hair extension ring and a thermal shrinkage ring and (6) threading. The step (5) includes sleeving the hair extension ring on a ring with hooked hair, sleeving the thermal shrinkage ring on the hair extension ring and heating the thermal shrinkage ring to enable the thermal shrinkage ring to be shrunk. The step (6) includes puncturing a hole in the hair extension ring from bottom to top through the thermal shrinkage ring and enabling an annular fish thread to penetrate through the hole from bottom to top. The hair extension bundle manufactured in the method does not use any adhesive, and does not cause infection. The hair extension bundle is flexible in texture and comfortable to wear.

The invention discloses a postoperative skin flap and reconstructed limb blood flow state detection epidermis attaching type sensing system, and belongs to the field of medical health monitoring. The system comprises a front-end state detection module and a rear-end signal processing output module, the front-end state detection module collects the blood oxygen saturation degree and the temperature state of a postoperative skin flap and a reconstructed limb in real time, a flexible packaging layer is adopted to package a printed circuit board, after the surface of the flexible packaging layer is chemically treated, a pre-polymerized hydrogel solution is injected for crosslinking to obtain a hydrogel adhesion layer, so that the hydrogel adhesion layer can be tightly attached to the skin for a long time, and meanwhile, bacterial infection on the skin surface is avoided; and the rear-end signal processing output module processes the oxyhemoglobin saturation and temperature data and sends the oxyhemoglobin saturation and temperature data to a mobile terminal in real time. According to the system, the postoperative skin flap and the blood flow health state of a reconstructed limb can be monitored on line, meanwhile, when the blood oxygen saturation degree of a human body is lower than a normal value or the body temperature and pulse signals are abnormal, the mobile terminal can trigger an alarm function to remind medical staff and patients in time.

The invention relates to a method for preparing a medical hemostatic gel dressing. Human-like collagen (LHC) is dissolved in ultrapure water to prepare a protein solution, and inorganic salts and complex cross-linking agents β-diimine zinc complex and 1,2,7,8-Diepoxyoctane, adjust the pH value of the solution to 2-5.5, stir evenly and place the mixed solution in a 40-80°C water bath for 0.5-5h, and then undergo two high-temperature steam treatments in sequence After washing with water, drying and Co-60 irradiation sterilization, a new type of sterile medical hemostatic gel dressing can be obtained. The medical hemostatic gel dressing prepared by the invention has good air permeability and antibacterial properties, will not cause wound infection, and can significantly shorten the hemostasis time. The hemostatic material will not adhere to the wound after hemostasis is completed, which significantly reduces the patient's pain.

The invention discloses a continuous dilution type complete sequential peritoneal dialysis solution treatment system with a complete sequential treatment function. The system comprises a water pipe butting port, a heating tank, a degassing tank, a mixing bucket, a peritoneal dialysis solution filter, a human body butting port and a waste liquid tank, wherein the devices are communicated through pipelines to form a pipeline system. The continuous dilution type complete sequential peritoneal dialysis solution treatment system with the complete sequential treatment function has the advantages that a peritoneal dialysis solution can be automatically prepared, the medicine solution is adjusted to meet the use standards, the efficiency of the peritoneal dialysis is improved, the use safety of patients is enhanced, and the time of the peritoneal dialysis of the patients is shortened.

The invention relates to a mesothelin high-expression cancer therapeutic vaccine based on recombinant attenuated Listeria ivanovii. Attenuated Listeria ivanovii (called Li for short) is used as a vector, and the unique ability of Listeria to grow in a host phagocytic cell is the characteristic of a natural T cell immune activation adjuvant, and is used to effectively improve the specific immune response in a tumor microenvironment and break the immune tolerance of bodies, so persistent viral infection of the bodies is removed, and good therapeutic effects of clearing focus and restraining tumor development are achieved. The cervical cancer therapeutic vaccine makes up for the shortcoming of low immunogenicity of nucleic acid and protein peptide vaccines, and the attenuated Listeria reserves the intracellular growth and antigen presentation completion characteristics of an original strain, and has a high safety.

The invention provides an intestine and stomach administration bioadhesive microsphere preparation. The intestine and stomach administration bioadhesive microsphere preparation comprises the followingraw materials: fish oil, glycerinum, polyethylene glycol, alpha-tocopherol, lactose and pectin. Compared with the prior art, the intestine and stomach administration bioadhesive microsphere preparation has the following beneficial effects: vitamin A can be supplemented for children; infection, tissue simulation, muscle injury, hematoma and neurological damage are avoided; high biocompatibility, high medicine loading capacity, high balling property and high slow release property are achieved; the side effect of the medicine is minimized.

The invention discloses a cutting device for a blood bag braid. The cutting device comprises a base, wherein the top of the base is integrally connected with an inlet, the bottom of the base is integrally connected with an outlet which is coaxial with the inlet, a pipeline channel is coaxially formed in the inlet, a liquid flow channel is coaxially formed in the outlet, a cavity is formed between the pipeline channel and the liquid flow channel and located in the base, the pipeline channel communicates with the liquid flow channel through the cavity, and a cutting assembly is detachably installed on one side of the outer portion of the base. By the adoption of the technical scheme, the cutting device is simple in structure and ingenious in concept, blood pollution is avoided in the using process, sealing cotton can ensure that blood does not flow out through a guide groove after the blood bag braid is cut off by a blade, the sealing performance of the guide groove is improved, the serious consequence of blood infection caused by the fact that the blood is stained on the hand of an operator is avoided, and higher safety is ensured through disposable use.

The invention relates to the technical field of medical equipment, in particular to a hip prosthesis and a preparation method. The hip prosthesis comprises an acetabulum (1), a femur head (2), a femur neck (3) and a femur stem (4), wherein the femur stem (4) adopts porous structures with different pore diameter ranges; the femur head (2), the femur neck (3) and the femur stem (4) are made of a niobium-contained titanium alloy material; a hydroxyapatite layer is arranged on each of the outer surface and the inner surface of the femur stem (4). Through application of the hip prosthesis, the stress shielding for a human femur can be reduced; meanwhile, the service life of the hip prosthesis is prolonged, and the biocompatibility is improved.