38results about How to "Does not cause infection" patented technology

The invention belongs to the field of medical implant materials and particularly relates to a novel biodegradable zinc-based metal material and a ureteral expandable stent obtained through the material. The zinc-based metal material is composed of zinc and/or zinc alloy. The zinc alloy is composed of Zn and one or more elements of Mg, Al, Ti, Cu, Ag, Si, Ca, Sr, Y, Zr, Sc, Gd, Nd, Dy, Er, Li, Mn, La, Ce, Pr, Sm, Tb, Ho, Tm, Yb and Lu. The biodegradable zinc-based metal material has good biocompatibility, degradability and mechanical properties, and has wide market application prospects.

The invention relates to a disinfection device, and especially relates to an inner barrel disinfection device for a washing machine. The invention provides an inner barrel disinfection device for a washing machine, which is time-saving and labor-saving and low in labor strength, disinfection is comprehensive, fungal infection can be prevented, and furthermore various skin diseases can be prevented. Accordingly, the invention provides the inner barrel disinfection device for the washing machine, and the inner barrel disinfection device comprises a base plate, a disposing plate, a vertical plate, a cylinder, arc-shaped clamping plates, supporting plates, a top plate, a hollow sleeve, a first spring, a slide bar, an arc-shaped brush, and a first disinfection apparatus; and the middle of the top of the base plate is provided with a rotating apparatus, a rotating part of the rotating apparatus is connected with the disposing plate, and the vertical plate is installed at the middle of the top of the disposing plate in a bolt connection manner. The effects that time and labor are saved, labor strength is low, disinfection is comprehensive, fungal infection can be prevented, and furthermore various skin diseases can be prevented are achieved.

The invention relates to a preparation method for a medical hemostasis hydrogel dressing. Human-like collagen (LHC) is dissolved into ultrapure water to prepare a protein solution, inorganic salt and a compound cross linker [beta]-diimine zinc complex and 1,2,7,8-diepoxy octane are added, the solution PH value is adjusted to 2-5.5, a mixed solution is placed into a water bath which is at the temperature of 40-80 DEG C to keep for 0.5-5 h after being stirred evenly, then the mixed solution is sequentially subjected to twice high-temperature vapor treatment and washing and finally subjected to drying treatment and Co-60 irradiation sterilization, and the novel sterile medical hemostasis hydrogel dressing can be obtained. According to the prepared medical hemostasis hydrogel dressing, the air permeability is good, the anti-microbial property is achieved, and wound infection cannot be caused; and the hemostatic time can be obviously shortened, a hemostatic material cannot adhere to a wound after hemostasis is completed, and the pain of a patient is obviously relieved.

The invention relates to a cervical cancer therapeutic vaccine based on recombinant attenuating sheep listeria ivanovii. By taking the attenuating sheep listeria ivanovii as a vector, specific immuneresponse in a tumor microenvironment is improved effectively and immune tolerance of a body is broken by means of a unique characteristic that the listeria ivanovii can grow in a main phagocyte and isa natural T cell immune activation adjuvant, so that continuous virus infection of the body is eliminated and the good therapeutic effect of eliminating the focus and inhibiting tumor development isachieved. The vaccine has the advantages that the defect that nucleic acid and protein polypeptide vaccines are relatively low in immunogenicity is made up, and the attenuating sheep listeria ivanoviialso has high safety while retaining the characteristic that an original strain can grow in cells to achieve antigen presentation.

The invention relates to a cervical cancer therapeutic vaccine based on recombinant attenuated Listeria monocytogenes. Attenuated Listeria monocytogenes (hereinafter referred to as Lm) is used as a vector, and the unique ability of Listeria to grow in a host phagocytic cell is the characteristic of a natural T cell immune activation adjuvant, and is used to effectively improve the specific immuneresponse in a tumor microenvironment and break the immune tolerance of bodies, so persistent viral infection of the bodies is removed, and good therapeutic effects of clearing focus and restraining tumor development are achieved. The cervical cancer therapeutic vaccine makes up for the shortcoming of low immunogenicity of nucleic acid and protein peptide vaccines, and the attenuated Listeria reserves the intracellular growth and antigen presentation completion characteristics of an original strain, and has a high safety.

The invention relates to application of recombinant attenuated listeria in the preparation of a mesothelin high-expression cancer therapeutic vaccine. By taking attenuated Listeria monocytogenes (Lm for short hereinafter) and attenuated Listeria ivanovii (Li for short hereinafter) as carriers, and special listeria can grow in phagocyte of a host and is a natural T-cell immune activation adjuvant,so that the specific immune response in a tumor microenvironment is effectively improved, the immune tolerance of a body is broken through, the continuous virus infection of the body is eliminated, and good treatment effects on the elimination of an infection focus and the containment of tumor development are achieved. The application has the advantages that the disadvantages that nucleic acid type vaccines and protein polypeptide type vaccines are relatively low in immunogenicity are remedied, the attenuated listeria preserves the properties that an original strain can grow in the cells and finish antigen presentation, and meanwhile, the attenuated listeria has relatively high safety.

The invention relates to application of recombinant attenuated Listeria in preparation of a therapeutic vaccine for cervical cancer. Attenuated Listeria monocytogenes (hereinafter referred to as Lm) and attenuated Listeria ivanovii (hereinafter referred to as Li) are used as vectors, by use of the unique characteristic that the Listeria can grow in phagocytose cells in a host, and is a natural T cell immune activation adjuvant, specific immune response in tumor microenvironment can be effectively enhanced, body's immune tolerance can be broken, body's persistent viral infection can be eliminated, and good treatment results of clearing focuses and curbing tumor development can be achieved. The Listeria has the advantages that shortcomings of low immunogenicity of nucleic acid and protein peptide vaccines can be made up, the attenuated Listeria retains the characteristic that an attenuated original strain can grow intracellularly to complete antigen presentation, and meanwhile the attenuated Listeria has higher safety.

The invention relates to a paste-liquid double-dosage-form cooperatively-used drug for treating plantar warts and periungual warts and a preparation method of the drug, solving the problem that a drug in the prior art is slow in effect and causes infection. Eleven traditional Chinese medicines, including, according to a weight ratio, 6-21 of isatis roots, 2-7 of safflowers, 5-15 of lightyellow sophora roots, 2-7 of rhizoma curcumae, 5-15 of cortex dictamni, 5-15 of belvedere fruits, 6-21 of rhizoma cyperi, 20-40 of common scouring rush herbs, 20-40 of purslane herbs, 5-15 of peach seeds, and 20-40 of radix arnebiae are used to prepare a small part of fine mixed powder and a large part of coarse mixed powder, wherein the fine mixed powder cooperates with ass hide glue and urea to prepare paste, and the coarse mixed powder is extracted with colored vinegar to make a liquid. The paste is made by melting ass hide glue powder with water, cooling the obtained product till the product can be touched with hands and doesn't burn hands, adding finely-ground urea, adding the fine mixed powder till the temperature of the obtained product is reduced to the room temperature, and performing uniform mixing. The liquid is obtained by soaking the coarse mixed powder with colored vinegar and performing filtering. The drug has a quick effect, doesn't cause infection, allows warts not to relapse, can repair the damage due to holes of warts and damaged cells, and can remove warts without leaving scars.

The invention relates to a mesothelin high-expression cancer treatment vaccine based on recombinant attenuated listeria monocytogenes. The attenuated listeria monocytogenes (Lm) is used as a carier, the characteristics that the Lm can specifically grow in a host phagocyte and is a natural T cell immune activated reagent are utilized, specific immune response in a tumor microenvironment can be effectively improved, the immune tolerance of a body can be broken, persistent viral infection of the body can be cleaned, and an excellent treatment effect for cleaning the focus and inhibiting tumor development can be achieved. The mesothelin high-expression cancer treatment vaccine has the advantages of overcoming the defect of relatively low immunogenicity of nucleotide and protein polypeptide vaccines, the attenuated listeria remained with original strains can grow in cells, so that higher safety is achieved while the characteristic of antigen presentation can be completed.

The invention discloses a KRAS high-expression cancer vaccine based on recombinant attenuated Listeria monocytogenes and a preparation method and application method thereof. The cancer vaccine is bacterial liquid of an Lm delta actA/ plcB-KRAS strain; the Lm delta actA/ plcB-KRAS strain is a gene recombinant bacterium carrying a KRAS protein gene by taking the attenuated Listeria monocytogenes asa carrier; the attenuated Listeria monocytogenes is obtained by completely knocking out two virulence genes of actA and plcB from the Listeria monocytogenes; and the KRAS protein gene is a DNA sequence obtained by synthesizing a KRAS protein amino acid sequence after being optimized by a Listeria codon, adding a Hind III restriction enzyme cutting site at the upstream and adding an Xho I restriction enzyme cutting site at the downstream. According to the KRAS high-expression cancer vaccine disclosed by the invention, the attenuated Listeria monocytogenes is used as the carrier, and the specific immune response in a tumor microenvironment is effectively improved by utilizing the characteristic that the Listeria monocytogenes can uniquely grow in a host phagocyte and is a natural T cell immune activation adjuvant, so that the immune tolerance of an organism is broken, and further the development of tumors can be inhibited.

The invention provides an autologous concentrated growth factor implant surface fusion device and method, relates to the field of oral implantation, and solves the technical problem of rejection reaction during implantation due to individual difference in existing implant surface treatment. The device comprises a tubular bottle body, wherein a bottom seal and an upper cover are respectively arranged at two open ends of the bottle body; the bottom seal is made of an elastic material; the upper cover is detachably arranged on the bottle body; and a built-in converter can be adaptively connectedwith a carrier of an implant. When the upper cover connected with the implant is mounted back to the bottle body, the implant is immersed in autologous blood, and the fusion device is placed on a centrifuge to separate out autologous concentrated growth factors; and the implant is immersed in the high-concentration growth factors, and the concentrated growth factors are attached to gaps in the surface of the implant to form an autologous surface, so that the fusion and reforming of the implant and bones are accelerated, the rejection reaction during foreign matter implantation is reduced, andthe survival rate of the implant is increased.

The invention belongs to the field of hair dressing articles and particularly relates to a manufacturing method for a hand hook hair extension bundle. The manufacturing method includes the following steps: (1) thread folding which includes folding a cotton thread into two threads and making a knot at one thread end; (2) fixing which includes fixing the cotton thread on a head mould through two pins; (3) hair hooking which includes hooking hair on the cotton thread through a crochet hook; (4) knot tying which includes taking off the cotton thread after hair hooking and tying the end with the knot and the end with a folding mark to enable the hair hooking portion to form a ring; (5) sleeving of a hair extension ring and a thermal shrinkage ring and (6) threading. The step (5) includes sleeving the hair extension ring on a ring with hooked hair, sleeving the thermal shrinkage ring on the hair extension ring and heating the thermal shrinkage ring to enable the thermal shrinkage ring to be shrunk. The step (6) includes puncturing a hole in the hair extension ring from bottom to top through the thermal shrinkage ring and enabling an annular fish thread to penetrate through the hole from bottom to top. The hair extension bundle manufactured in the method does not use any adhesive, and does not cause infection. The hair extension bundle is flexible in texture and comfortable to wear.

The invention relates to a mesothelin high-expression cancer therapeutic vaccine based on recombinant attenuated Listeria ivanovii. Attenuated Listeria ivanovii (called Li for short) is used as a vector, and the unique ability of Listeria to grow in a host phagocytic cell is the characteristic of a natural T cell immune activation adjuvant, and is used to effectively improve the specific immune response in a tumor microenvironment and break the immune tolerance of bodies, so persistent viral infection of the bodies is removed, and good therapeutic effects of clearing focus and restraining tumor development are achieved. The cervical cancer therapeutic vaccine makes up for the shortcoming of low immunogenicity of nucleic acid and protein peptide vaccines, and the attenuated Listeria reserves the intracellular growth and antigen presentation completion characteristics of an original strain, and has a high safety.