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Method for micro-wounded dynamically and continuously detecting blood sugar concentration of human body

A technology for blood glucose concentration and detection method, which is applied in blood characterization devices, diagnostic recording/measurement, medical science, etc., can solve problems such as small volume of tissue fluid, achieve high measurement resolution and measurement accuracy, small volume of tissue fluid to be measured, The effect of measuring fast

Inactive Publication Date: 2008-07-09
TANJIN SUNSHINE QPTICS TECH
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Problems solved by technology

[0008] Another technical problem to be solved by the present invention is to provide a method of diluting the tissue fluid with a buffer and detecting it using a high-sensitivity surface plasmon resonance protein binding measurement technology to solve the problem that the volume of tissue fluid obtained during each extraction process is very small. Minimally invasive, dynamic, continuous detection method for human blood glucose concentration of glucose concentration in interstitial fluid

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  • Method for micro-wounded dynamically and continuously detecting blood sugar concentration of human body
  • Method for micro-wounded dynamically and continuously detecting blood sugar concentration of human body
  • Method for micro-wounded dynamically and continuously detecting blood sugar concentration of human body

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Embodiment Construction

[0056] The minimally invasive, dynamic and continuous detection method of human blood glucose concentration of the present invention is realized on the micro-flow liquid comprehensive processing system disclosed in the patent application with the application number of 200810052117.9. First, the skin is pretreated with low-frequency ultrasound, and the lipid bilayer structure in the stratum corneum of the skin is destroyed by the cavitation of low-frequency ultrasound to increase the permeability of the skin, and then the tissue fluid is quickly extracted from the skin by vacuum negative pressure. , and detect the skin impedance / resistance during the tissue fluid extraction process, and then transport the extracted tissue fluid to the surface plasmon resonance measurement system through the microchannel, and use the surface plasmon resonance protein binding measurement technology to measure the glucose concentration in human tissue fluid, and finally use The volume of tissue flu...

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Abstract

A minimally invasive, dynamic and continuous detection method for human blood glucose concentration, including: firstly, using low-frequency ultrasound for the pretreatment on skin; secondly, extracting human tissue fluid from the skin after the low-frequency ultrasound pretreatment under the vacuum negative function; thirdly, detecting the skin impedance / resistance during the permeable skin tissue liquid extraction process; fourthly, measuring the glucose concentration of the extracted human tissue liquid; fifthly, using the skin impedance / resistance to determine the extracted tissue liquid volume and to establish the prediction model of the correlation between the glucose concentration in the tissue liquid and the glucose concentration in blood; sixthly, obtaining the human blood glucose concentration according to the skin impedance / resistance that is measured in the third step, the glucose concentration of the human tissue liquid that is measured in the fourth step and the prediction model that is established in the fifth step. The invention can realize the minimally invasive, dynamic and continuous detection method for the human blood glucose concentration and has the advantages of high measurement resolution and precision, good stability of the measured result, small tissue liquid amount to be measured, rapid measuring speed, etc.

Description

technical field [0001] The invention relates to a method for detecting the blood glucose concentration of a human body. In particular, it relates to a minimally invasive, dynamic and continuous detection method of human blood glucose concentration based on low-frequency ultrasonic skin antireflection technology, vacuum negative pressure extraction technology, skin impedance / resistance measurement technology and surface plasmon resonance measurement technology. Background technique [0002] Diabetes is a common and frequently-occurring disease among middle-aged and elderly people. With the improvement of people's living standards, the incidence of diabetes is also increasing. The World Health Organization lists it as one of the three most difficult diseases in the world, along with tumors and cardiovascular and cerebrovascular diseases. . According to the estimates of the International Diabetes Federation, there are currently more than 240 million diabetic patients in the wo...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/145A61B5/157A61B5/053
Inventor 徐可欣于海霞栗大超杜振辉
Owner TANJIN SUNSHINE QPTICS TECH
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