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Preparation method for novel medical hemostasis hydrogel dressing

A hemostatic gel, a new type of technology, applied in the field of medical materials, can solve the problems of easy adhesion of wounds, poor air permeability, etc., and achieve the effects of good biocompatibility, strengthened cross-linking, and optimized pore-forming effect

Active Publication Date: 2017-11-17
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the defects of poor gas permeability and easy adhesion to wounds of hemostatic materials on the market, the present invention prepares a new type of medical hemostatic gel dressing that can quickly stop bleeding and does not adhere to tissues. The method is simple in process and the prepared material is biocompatible Good performance, it is expected to be widely used in wartime first aid kits, clinical operation hemostasis, etc.

Method used

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  • Preparation method for novel medical hemostasis hydrogel dressing
  • Preparation method for novel medical hemostasis hydrogel dressing
  • Preparation method for novel medical hemostasis hydrogel dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of medical hemostatic porous gel dressing

[0026] Step 1: Dissolve the water-soluble human-like collagen HLC in 10 mL distilled water to obtain a solution with a concentration of 100 mg / mL, and add cross-linking agent β-diimine zinc complex and 1,2,7 , 1 mL each of 8-dioxoctane, then add 2 mL of 10 mg / mL KCl, mix well, and adjust the pH of the solution to 4.5 with dilute hydrochloric acid and sodium hydroxide;

[0027] Step 2: Divide the mixed solution in step 1 into molds, keep at 50°C for 2 hours, then transfer to a high-pressure steam sterilizer and keep at 121°C for 20 minutes to obtain the primary gel product;

[0028] Step 3: soak and wash the primary gel in step 2 with distilled water for 5 days, change the washing water every 6 hours to remove salt and residual cross-linking agent; transfer the washed primary gel to an autoclave to continue Keep at 121°C for 2 h, then soak and wash with distilled water for 2 days again, control the total ...

Embodiment 2

[0033] Example 2 Preparation of medical hemostatic porous gel dressing

[0034] Step 1: Dissolve the water-soluble human-like collagen HLC in 10 mL distilled water to obtain a solution with a concentration of 100 mg / mL, and add 2% cross-linking agent β-diimine zinc complex and 1,2,7 , 1 mL each of 8-dioxoctane, and then add 10 mg / mL Na 2 SO 4 Solution 2mL, mix well, and adjust the pH of the solution to 4 with dilute hydrochloric acid and sodium hydroxide;

[0035] Step 2: Divide the mixed solution in step 1 into molds, keep it in a water bath at 60°C for 2 hours, then transfer it to a high-pressure steam sterilizer and keep it at 110°C for 20 minutes to obtain the primary gel product;

[0036] Step 3: soak and wash the primary gel in step 2 with distilled water for 5 days, change the washing water every 6 hours to remove salt and residual cross-linking agent; transfer the washed primary gel to an autoclave to continue Keep at 110°C for 2 h, then soak and wash with distilled w...

Embodiment 3

[0039] Example 3 Preparation of medical hemostatic porous gel dressing

[0040] Step 1: Dissolve the water-soluble human-like collagen HLC in 20 mL distilled water to obtain a solution with a concentration of 200 mg / mL, and add cross-linking agent β-diimine zinc complex and 1,2,7 , 4 mL each of 8-dioxoctane, and then add 10 mg / mL NaH 2 PO 4 Solution 2mL, mix well, and adjust the pH of the solution to 5.5 with dilute hydrochloric acid and sodium hydroxide;

[0041] Step 2: Divide the mixed solution in step 1 into molds, keep it at 70°C for 2 hours, then transfer it to a high-pressure steam sterilizer and keep it at 121°C for 20 minutes to obtain the primary gel product;

[0042] Step 3: soak and wash the primary gel in step 2 with distilled water for 4 days, change the washing water every 6 hours to remove salt and residual cross-linking agent; transfer the washed primary gel to an autoclave to continue Keep at 121°C for 3 h, then soak and wash with distilled water for 1 day...

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Abstract

The invention relates to a preparation method for a medical hemostasis hydrogel dressing. Human-like collagen (LHC) is dissolved into ultrapure water to prepare a protein solution, inorganic salt and a compound cross linker [beta]-diimine zinc complex and 1,2,7,8-diepoxy octane are added, the solution PH value is adjusted to 2-5.5, a mixed solution is placed into a water bath which is at the temperature of 40-80 DEG C to keep for 0.5-5 h after being stirred evenly, then the mixed solution is sequentially subjected to twice high-temperature vapor treatment and washing and finally subjected to drying treatment and Co-60 irradiation sterilization, and the novel sterile medical hemostasis hydrogel dressing can be obtained. According to the prepared medical hemostasis hydrogel dressing, the air permeability is good, the anti-microbial property is achieved, and wound infection cannot be caused; and the hemostatic time can be obviously shortened, a hemostatic material cannot adhere to a wound after hemostasis is completed, and the pain of a patient is obviously relieved.

Description

technical field [0001] The invention relates to a preparation method of a medical hemostatic gel dressing, which belongs to the field of medical materials. Background technique [0002] Bleeding due to war, traffic accidents, sports or disease and other factors that cause various epidermal or tissue traumas in the body. In recent years, many studies have shown that a large proportion of patients died of excessive blood loss clinically. Therefore, it is an urgent need to prepare a hemostatic material that can quickly stop bleeding without sticking to the tissue to gain time for later rescue and treatment. solved problem. [0003] The main characteristics of ideal dressings currently used for wounds are generally: non-toxic, non-sensitive, and non-allergic; closely attached to the wound, and have good hygroscopic properties, which can keep the environment moist between the wound and the dressing; frequent dressings are not required. Replacement; impermeable to microorganisms...

Claims

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Application Information

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IPC IPC(8): A61L26/00A61L24/10A61L24/00C08J3/24C08L89/00
CPCA61L24/0031A61L24/0036A61L24/102A61L26/0033A61L26/008A61L26/0085A61L2400/04C08J3/243C08J2389/00
Inventor 范代娣惠俊峰朱晨辉马晓轩郑晓燕姜西娟
Owner NORTHWEST UNIV
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