Intestine and stomach administration bioadhesive microsphere preparation

A technology of bioadhesion and drug delivery, which is applied in the direction of drug delivery, pharmaceutical formulations, active ingredients of hydroxyl compounds, etc., can solve the problems of practical transformation and application of bioadhesive particle preparations, and achieve small side effects, good sustained release, and high cost-effectiveness. good ball effect

Inactive Publication Date: 2018-09-07
GUANGDONG YIMING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nonetheless, there are still several obstacles to the practical translational application of bioadhesive microparticle formulations

Method used

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Embodiment Construction

[0010] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments.

[0011] The invention provides a technical solution: a bioadhesive microsphere preparation for gastrointestinal administration, which is composed of the following raw materials: fish oil, glycerin, polyethylene glycol, α-tocopherol, lactose, and pectin.

[0012] Under 150°C and 1.37MPa carbon dioxide pressure, epichlorohydrin is hydrolyzed in an aqueous solution of 10% sodium hydroxide and 1% sodium carbonate to generate a glycerin aqueous solution containing sodium chloride with a glycerin content of 5-20%, which is concentrated , desalination and distillation to obtain glycerol in the raw material, the purity of which is greater than 98.4%.

[0013] In the liquid medium, the ether bond on the molecular surface of polyethylene glycol has a weak ne...

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Abstract

The invention provides an intestine and stomach administration bioadhesive microsphere preparation. The intestine and stomach administration bioadhesive microsphere preparation comprises the followingraw materials: fish oil, glycerinum, polyethylene glycol, alpha-tocopherol, lactose and pectin. Compared with the prior art, the intestine and stomach administration bioadhesive microsphere preparation has the following beneficial effects: vitamin A can be supplemented for children; infection, tissue simulation, muscle injury, hematoma and neurological damage are avoided; high biocompatibility, high medicine loading capacity, high balling property and high slow release property are achieved; the side effect of the medicine is minimized.

Description

technical field [0001] The invention relates to a bioadhesive microsphere preparation for gastrointestinal administration, which belongs to the technical field of pharmaceutical preparations. Background technique [0002] Since the 1990s, bioadhesive sustained-release microparticle preparations have a large specific surface area, can easily enter the mucous layer and have a strong adhesion to the mucous membrane, and at the same time have a good The advantages of slow and controlled release drugs have once become a hot spot in the research of new drug dosage forms. Nevertheless, there are still several obstacles to the practical translational application of bioadhesive microparticle formulations. [0003] Bioadhesive drug delivery system is a kind of natural or synthetic polymer material, through which it has a long-term close contact with the surface of the mucous membrane of the body tissue, thereby prolonging the residence time of the drug in the mucous membrane or mucus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K35/60A61K31/07A61K31/355
CPCA61K9/0065A61K9/1617A61K9/1623A61K9/1641A61K9/1652A61K31/07A61K31/355A61K35/60A61K2300/00
Inventor 李易春
Owner GUANGDONG YIMING PHARMA
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