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Biodegradable stent composite

A composition and alloy technology, which is applied in medical science, surgery, coating, etc., can solve the problems of no reports and related products that have not been listed.

Inactive Publication Date: 2015-12-23
COMSCAFFOLDS NANJING MEDICAL DEVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] There is no report on the application of degradable polycaprolactone polyurethane as a coating to prepare stents and make stent grafts, and no related products have been listed.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0068] The magnesium alloy composition table that embodiment 1-9 selects is for example as follows:

[0069]

[0070] 8

[0071] Magnesium metal stent materials can also choose high-purity magnesium or high-purity iron according to different degradation times.

Embodiment 1

[0072] Example 1: Vascular covered stent

[0073] Its preparation process is as follows:

[0074] (1) Prepare, engrave, etch or cut degradable metal materials (alloy composition ratio according to list 9) into required patterns or laths (such as figure 1 Various shapes shown), the diameter of the bracket is 1mm, and the length is 2cm;

[0075] (2) Polish the stent prepared in (1), soak it in 30% hydrofluoric acid for 24 hours, take it out, wash it with 75% ethanol, and dry it.

[0076] (3) Polymer A: degradable medical polyurethane material (viscosity average molecular weight 10,000, breaking strength 35MPa, breaking elongation 350%) is dissolved in chloroform solvent, spreads 0.2-0.3 on the tetrafluoroethylene plate mm thick film;

[0077] (4) roll the film prepared in (3) on the metal material surface of the metal stent prepared in (1) to make a covered stent (such as Figure 5 shown);

[0078] (5) The composite material prepared in (4) is dried, polished, and polished ...

Embodiment 2

[0079] Example 2: Double balloon urethral stent graft

[0080] Made of silicone material such as figure 1 In the double-balloon urethral stent shown, the stent is pressed or adhered to the columnar balloon, and after being placed in the urethra, gas is injected into the balloon, and the columnar balloon expands the stent and supports it in the urethra.

[0081] Wherein the peritoneal urethral stent, its preparation process is as follows:

[0082] (1) Prepare, engrave, etch or cut degradable metal materials (alloy composition ratio according to list 9) into required patterns or laths (such as Figure 6 Various shapes shown), the diameter of the bracket is 3mm, and the length is 2cm;

[0083] (2) Polymer A: degradable medical polyurethane material and polymer B: PLGA (wherein LA: GA ratio is 70: 30, viscosity average molecular weight is 80,000) are mixed and dissolved in dichloromethane solvent by 1: 2, Lay a 0.2-0.3mm thick film on the tetrafluoroethylene board;

[0084] (3...

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Abstract

The invention discloses a biodegradable stent composite. The biodegradable stent composite is prepared from biodegradable medical polyurethane and a biodegradable metal material. The weight ratio between the biodegradable medical polyurethane and the biodegradable metal material is 0.1-99%:1-99.9%, preferably 5-90%:10-95%. To regulate the hardness of the material, other high molecular materials, such as polylactic acid, polycaprolactone, poly-p-dioxanone and copolymers thereof (PPDO and P(LA-PDA)), poly trimethylene carbonate, polylactic acid-trimethylene carbonate copolymer, polycaprolactone-trimethylene carbonate copolymer, polyglycolic acid and polylactic acid-glycolic acid copolymer, can be added, so that clinical usage is facilitated.

Description

technical field [0001] The invention belongs to the field of medical biomaterials and technology, in particular to a degradable bracket composition. Background technique [0002] Degradable stents include polymer material stents and degradable metal stents, among which degradable polymer materials include: PLLA, PLA, PGA, PDO and PCL, among which PLLA has good rigidity, flexibility, stability and heat resistance , has been successfully applied to metal stent coating materials and self-prepared stents; degradable metal stent materials include magnesium alloy and iron alloy materials, and magnesium alloy materials have gradually become the mainstream of degradable stent research due to their excellent processing properties. Due to the alkaline environment and hydrogen generated during the degradation process of magnesium alloy materials, a large number of applications are limited; because tissues and organs in different parts such as blood vessels, trachea, and urethra have di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/10A61L31/14
Inventor 薛波新管建均白晶张文芳
Owner COMSCAFFOLDS NANJING MEDICAL DEVICE CO LTD
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