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Composition containing retinoic acid nanoparticles coated with polyvalent metal inorganic salt

A technology of nanoparticles and polyvalent metals, applied in the direction of nanomedicine, medical preparations containing active ingredients, nanotechnology, etc., can solve the problems of insufficient and effective preparation of nanoparticles, and achieve low irritation and good percutaneous absorption Effect

Inactive Publication Date: 2006-11-08
NANOEGG RES LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, retinoic acid nanoparticles coated with polyvalent metal inorganic salts such as calcium carbonate formed as described above have a particle size (diameter) of about 5 to 1000 nm, and it is not possible to sufficiently efficiently prepare nanoparticles having a desired particle size. particles

Method used

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  • Composition containing retinoic acid nanoparticles coated with polyvalent metal inorganic salt
  • Composition containing retinoic acid nanoparticles coated with polyvalent metal inorganic salt
  • Composition containing retinoic acid nanoparticles coated with polyvalent metal inorganic salt

Examples

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Effect test

preparation example 1

[0184] Preparation Example 1: External Ointment / Hydrogel

[0185] Take appropriate amount of retinoic acid-CaCO 3 Nanoparticles (average particle diameter: about 20 nm), white petrolatum, carboxymethylcellulose and methylparaben were mixed until uniform to obtain ointment and hydrogel containing retinoic acid 0.3%.

preparation example 2

[0186] Preparation example 2: external patch (water-based cataplasm)

[0187] (formula)

[0188] Retinoic Acid-CaCO 3 Nanoparticles 0.1% by weight

[0189] (or retinoic acid-ZnCO 3 nanoparticles)

[0190] Polyacrylic acid 2.0% by weight

[0191] Sodium polyacrylate 5.0% by weight

[0192] Sodium carboxymethylcellulose 2.0% by weight

[0193] Gelatin 2.0% by weight

[0194] Polyvinyl alcohol 0.5% by weight

[0195] Glycerin 25.0% by weight

[0196] Kaolin 1.0% by weight

[0197] Sodium hydroxide 0.6% by weight

[0198] Tartaric acid 0.3% by weight

[0199] EDTA-2-Sodium 0.1% by weight

[0200] Purified water balance

[0201] By mixing the above ingredients, an external patch (water-based cataplasm) is obtained according to a conventional method

preparation example 3

[0202] Formulation Example 3: Cosmetic cream

[0203] 1 part of carboxyvinyl polymer was dissolved in 89 parts of purified water, and a solution obtained by dissolving 0.4 part of potassium hydroxide in 9.6 parts of purified water was added thereto to obtain 100 parts of alkali-neutralized aqueous gel of carboxyvinyl polymer. share.

[0204] Next, using the aqueous gel obtained above, according to the following formulation, a cosmetic cream was obtained according to a conventional method.

[0205] Retinoic Acid-CaCO 3 Nanoparticles 0.1 parts

[0206] 30 parts of the aqueous gel obtained above

[0207] 10 parts liquid paraffin

[0208] Glycerin 22.7 parts

[0209] 0.3 parts of methyl p-hydroxybenzoate

[0210] Stearic acid 10 parts

[0211] Appropriate amount of spices

[0212] Purified water balance

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Abstract

It is intended to provide a composition containing, as the active ingredient, retinoic acid nanoparticles having relieved irritation, which can be subcutaneously and intravenously administered, is usable as a sustained release preparation, and has such a high skin-permeability as allowing the use thereof as an external preparation such as a drug or a quasi drug as well as a cosmetic to be applied to the skin, etc. When dissolved in water, the retinoic acid nanoparticles coated with a polyvalent metal inorganic salt, i.e., the active ingredient, are maintained in the form of a transparent solution and, therefore, can be administered as a subcutaneous or intravenous injection. Since retinoic acid is coated with a polyvalent metal inorganic salt film, these nanoparticles are characterized by showing relieved irritation and thus causing neither inflammation nor canceration at administration site. As the polyvalent metal inorganic salt, use is made of calcium carbonate, zinc carbonate or calcium phosphate.

Description

technical field [0001] The present invention relates to retinoic acid nanoparticles coated with multivalent metal inorganic salts as an active ingredient, particularly retinoic acid nanoparticles coated with calcium carbonate, zinc carbonate or calcium phosphate as a multivalent metal inorganic salt as an active ingredient. Composition of active ingredients. Specifically, it relates to oral preparations, parenteral preparations, external preparations, and cosmetics containing retinoic acid nanoparticles coated with calcium carbonate, zinc carbonate, or calcium phosphate as an active ingredient. Background technique [0002] In recent years, retinoic acid, which is a fat-soluble retinoic acid, has been attracting attention for its differentiation-inducing effect in various undifferentiated cells including ES cells (embryostem cells: embryonic stem cells). The clinical application of the therapeutic drug for leukemia is also in progress. [0003] However, retinoic acid is a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/203A61K8/04A61K8/14A61K8/36A61K8/67A61K9/06A61K9/50A61K9/51A61K9/70A61P3/02A61P17/00A61Q19/00A61Q19/08
CPCA61K8/0241A61K8/0291A61K8/671A61K9/501A61K9/5115A61K2800/413A61K2800/621A61Q19/00A61Q19/08A61P3/02A61P17/00A61P35/02B82Y5/00
Inventor 山口叶子五十岚理慧水岛裕武永美津子N·中村
Owner NANOEGG RES LAB
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