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Porous degradable blood vessel and preparation method thereof

A vascular and wet spinning technology, applied in the directions of vascular, wet spinning, rayon manufacturing, etc., can solve the problems that whole-cell biological blood vessels cannot be widely used, easy to cause thrombosis, and long time, and achieve no allergic reaction, Reduce patient pain, good chemical stability

Inactive Publication Date: 2013-01-16
冯淑芹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after clinical trials, it was found that it also has obvious shortcomings.
It is prone to blood clots and it takes a long time to obtain this vascular substitute
Therefore, there is a bottleneck in its research, and whole-cell biological blood vessels without scaffolds have not been widely used.

Method used

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  • Porous degradable blood vessel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Preparation of spinning solution:

[0034] Dissolve the PCL raw material and PEO together in tetrahydrofuran, and stir with a magnetic stirrer at 10°C to form a uniform and transparent spinning solution. The total number of parts by weight of PCL and PEO is 10; The number of THF parts is 90; The weight ratio of PCL and PEO is 4: 1;

[0035] Hollow fiber preparation:

[0036] Let the spinning solution stand for half an hour for defoaming and then inject it into the spinning kettle, and connect it to the figure 1 On the electric thruster shown; then install the spinning head, inject acetone, open the high-pressure nitrogen bottle that drives the flow of acetone, and start the propeller again when the flow of the core liquid is stable. Perform wet spinning.

[0037]Wet spinning is carried out, the hollow fiber is received in a coagulation bath with a weight ratio of water and acetone of 50 / 50, the fiber is pulled through a godet roller and a godet roller, and wound onto...

Embodiment 2

[0041] Preparation of spinning solution:

[0042] Dissolve the PCL raw material and PVP together in chloroform, and stir with a magnetic stirrer at 50°C to form a uniform and transparent spinning solution. The total parts by weight of PCL and PVP is 40; The parts of chloroform are 60; The weight ratio of PCL and PVP is 1: 4;

[0043] Hollow fiber preparation:

[0044] Let the spinning solution stand for half an hour for defoaming and then inject it into the spinning kettle, and connect it to the figure 1 On the screw propeller shown; then install the spinning head, inject acetone, open the high-pressure carbon dioxide bottle that promotes the flow of ethanol, and start the propeller again when the flow of the core liquid is stable. Perform wet spinning.

[0045] Wet spinning is carried out, the hollow fiber is received in a coagulation bath with a weight ratio of water and acetone of 100 / 0, the fiber is pulled through a godet roller and a godet roller, and wound onto a wind...

Embodiment 3

[0049] Preparation of spinning solution:

[0050] Dissolve the PCL raw material and PVA in methyl formate, and stir with a magnetic stirrer at 100°C to form a uniform and transparent spinning solution. The total number of parts by weight of PCL and PVA is 20; The number of methyl formate parts is 80; The weight ratio of PCL and PVA is 9: 1;

[0051] Hollow fiber preparation:

[0052] Let the spinning solution stand for half an hour for defoaming and then inject it into the spinning kettle, and connect it to the figure 1 On the electric thruster shown; then install the spinning head, inject acetone, open the high-pressure carbon dioxide bottle that drives the flow of acetone, and start the propeller again when the flow of the core liquid is stable. Perform wet spinning.

[0053] Wet spinning is carried out, the hollow fiber is received with an acetone coagulation bath, the fiber is drawn through godet rollers and godet rollers, and wound onto a winder. When the fibers are u...

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Abstract

The invention aims to provide a porous degradable blood vessel prepared by a wet method spinning process and a preparation method thereof. The blood vessel is prepared from hollow fiber, has rough and porous surface, contributes to adhesion and growth of vascular cells, and has an effect of regenerating vascular tissues. The preparation method is simple, economic and suitable for industrialized production. The blood vessel has the inner diameter of 0.01 mm to 1 cm, the outer diameter of 0.02 mm to 2 m and the thickness of 0.01 mm to 5 mm. The preparation method comprises the following steps: dissolving a PLC raw material and additives into an organic solvent to prepare a uniform and transparent spinning solution at a certain temperature; standing and defoaming the spinning solution for half an hour, injecting the spinning solution into spinning equipment, injecting core liquid and performing wet method spinning; continuously immersing the hollow fiber into washing liquid for 0.5 minute to 48 hours to remove the residual core liquid and additives; repeatedly washing with deionized water, soaking for 0.5 minute to 48 hours, performing vacuum drying, and intercepting to prepare a vascular stent.

Description

technical background [0001] Cardiovascular diseases seriously endanger human health. The main treatment method is vascular bypass surgery, which requires vascular grafts of various diameters as repair materials. Therefore, vascular reconstruction plays a very important role in clinical surgery. Since Voorhees first successfully developed vinylon artificial blood vessels in 1952, this method has indeed played a certain effect, but this artificial blood vessel will hinder the formation of normal blood vessel structure. Other non-degradable materials such as PTFE and Dacron also hinder the formation of collagen and elastin by vascular cells, and these synthetic materials will become physical obstacles during the long-term application of blood vessels. [0002] In addition, in 1998, L'Heureux et al constructed a tissue-engineered blood vessel without a stent. The smooth muscle cells and fibroblasts are cultured separately in a culture system containing ascorbic acid, and thin s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06A61L27/18D01D5/06D01D5/24D01F6/92D01F1/10D01F8/14
Inventor 冯淑芹
Owner 冯淑芹
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