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Method for improving hydrophily and flexibility of polypeptide membrane by poly(trimethylene carbonate) and polyethylene glycol

A technology of methyl carbonate and polyethylene glycol, applied in the field of polymer film preparation, to achieve the effect of improving the hydrophilicity and flexibility of the polypeptide modified film, simple operation, and easy to master

Inactive Publication Date: 2015-04-29
SHANDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the improvement of the hydrophilicity and flexibility of the polypeptide film with polytrimethylene carbonate and polyethylene glycol.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Block Copolymer

[0018] 16.2 g of poly(r-benzyl-L-glutamate) (molecular weight 80,000) and 7 g of carboxy-terminated polytrimethylene carbonate monolauryl ether (molecular weight 3,000) were added to the dry reactor ), add 300 ml DMSO, and then add 0.048 g N,N' -Dicyclohexylcarbodiimide, stirred and reacted at 25°C for 3 days under an inert atmosphere, terminated the reaction, and obtained the target product by filtration, dialysis, and drying;

[0019] 2) Synthesis of polyethylene glycol-polytrimethylene carbonate block copolymer

[0020] Add 3 g of amino-terminated polyethylene glycol monomethyl ether (molecular weight: 5,000) and 9 g of carboxy-terminated polytrimethylene carbonate monolauryl ether (molecular weight: 3,000) into the dry reactor, add 160 ml Dimethyl sulfoxide, then add 0.145 g N,N' -Dicyclohexylcarbodiimide, under an inert atmosphere, stirred and reacted at 25°C for 2 days, then terminated t...

Embodiment 2

[0025] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Block Copolymer

[0026] 16.3 g of poly(r-ethyl-L-glutamate) (molecular weight 85,000) and 7 g of carboxy-terminated polytrimethylene carbonate monolauryl ether (molecular weight 3,500) were added to the dry reactor , add 305 ml of dimethyl sulfoxide, then add 0.031 g of N,N'-diisopropylcarbodiimide, under an inert atmosphere, stir and react at 27°C for 4 days, terminate the reaction, filter, dialyze, and dry, get the target

[0027] 2) Synthesis of polyethylene glycol-polytrimethylene carbonate block copolymer

[0028] Add 3 g of amino-terminated polyethylene glycol monomethyl ether (molecular weight: 6000) and 9 g of carboxy-terminated polytrimethylene carbonate monolauryl ether (molecular weight: 3500) into the dry reactor, add 155 ml Dimethyl sulfoxide, then add 0.08 g N,N' -Diisopropylcarbodiimide, under an inert atmosphere, stirred at 28°C for 3 days, then terminated the reaction, filtered, dialyzed, and d...

Embodiment 3

[0033] 1) Synthesis of Polypeptide-Polytrimethylene Carbonate Block Copolymer

[0034] Add 16.5 g of poly(r-methyl-L-glutamate) (molecular weight 92,000) and 7 g of carboxy-terminated polytrimethylene carbonate monolauryl ether (molecular weight 4,000) into a dry reactor , add 310 ml of dimethyl sulfoxide, then add 0.046 g of 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, and stir the reaction at 30°C for 3 days under an inert atmosphere to terminate the reaction. Through filtration, dialysis, and drying, the target object is obtained;

[0035] 2) Synthesis of polyethylene glycol-polytrimethylene carbonate block copolymer

[0036] Add 3.1 g of amino-terminated polyethylene glycol monomethyl ether (molecular weight: 7100) and 9.2 g of carboxyl-terminated polytrimethylene carbonate monolauryl ether (molecular weight: 4000) into the dry reactor, add 158 ml Dimethyl sulfoxide, then add 0.141 g of 3-ethyl-1-(3-dimethylaminopropyl) carbodiimide, under an inert atmosphere, stir an...

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PUM

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Abstract

The invention discloses a method for improving the hydrophily and flexibility of a polypeptide film by poly(trimethylene carbonate) and polyethylene glycol. The method comprises the following steps: (1) adding carboxy terminated poly(trimethylene carbonate) monododecyl ether, a solvent, a condensing agent and a polypeptide homopolymer into a dried reactor, and reacting for 3-4 days to obtain a polypeptide-poly(trimethylene carbonate) segmented copolymer; (2) adding carboxy terminated poly(trimethylene carbonate) monododecyl ether, a solvent, a condensing agent and amino terminated methoxy polyethylene glycol into a dried reactor, and reacting for 2-3 days to obtain a polyethylene glycol-poly(trimethylene carbonate) segmented copolymer; (3) adding the polypeptide-poly(trimethylene carbonate) segmented copolymer, the polyethylene glycol-poly(trimethylene carbonate) segmented copolymer and a solvent into a dried reactor, mixing for 40-50 minutes, forming a film by a tape casting method, and drying to obtain the target object. The preparation process is simple, and the hydrophily and flexibility of the modified film can be greatly improved.

Description

technical field [0001] The invention relates to a method for improving the hydrophilicity and flexibility of a polypeptide film with polytrimethylene carbonate and polyethylene glycol, and belongs to the technical field of polymer film preparation. Background technique [0002] Polypeptide is a biomaterial with good biocompatibility and biodegradability. Polypeptide film can be used as artificial skin, etc., but the polypeptide film is relatively stiff and lacks hydrophilicity, which limits its application. Polytrimethylene carbonate has better biocompatibility and biodegradability, and is relatively soft. Polyethylene glycol has good biocompatibility and biodegradability, is relatively soft and has good hydrophilicity. Firstly, the polytrimethylene carbonate segment is introduced into the polypeptide segment and the polyethylene glycol segment to form a polypeptide-polytrimethylene carbonate block copolymer and a polyethylene glycol-polytrimethylene carbonate block copoly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L87/00C08J5/18C08G81/00
Inventor 朱国全王发刚柳玉英
Owner SHANDONG UNIV OF TECH
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