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Absorbable vessel ligature clamp and preparation method thereof

A technique for ligating blood vessels and ligating clips, which is applied in the field of preparation of the blood vessel ligating clips, can solve the problems of not developing the biocompatibility of medical materials, the degradation time of the ligation clips is not adjustable, and the degradation time of the blood vessel ligation clips is very short, and the invention achieves Enhanced biocompatibility, controllable degradation performance, and improved biocompatibility

Active Publication Date: 2013-03-20
HANGZHOU MEDZONE BIO-TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patent Document 1 discloses a method for preparing high-molecular-weight polydioxanone, but there is no research on the biocompatibility of medical materials prepared from polydioxanone, and its preparation of medical consumables Research on Processing and Forming Technology for Timely Mass Production
The existing known polydioxanone material is flexible, and the medical consumables made of this material are not strong enough, and the molding process needs to be further optimized
The materials used in the ligation clips made in Patent Documents 2 and 3 are blends of polylactic acid and polyglycolic acid. Although these materials have acceptable biocompatibility, the degradation time of the ligation clips cannot be adjusted.
[0005] Although the performance of vascular ligation clips has been greatly improved after years of research in the industry, the improvement of vascular ligation clips has always been carried out around degradable aliphatic polyester homopolymers or copolymers, and the regulation of vascular ligation clip degradation There are few literature reports on time

Method used

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  • Absorbable vessel ligature clamp and preparation method thereof
  • Absorbable vessel ligature clamp and preparation method thereof
  • Absorbable vessel ligature clamp and preparation method thereof

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preparation example Construction

[0041] In addition to the above-mentioned biodegradable aliphatic polyester material, the raw materials for the preparation of the vascular ligation clip of the present invention may contain other conventional auxiliary agents that do not impair its biodegradability, such as medical pigments such as D&C Purple No. 2.

[0042] After the vascular ligation clip is prepared, the present invention further studies its degradation behavior in a buffer solution simulating a body fluid environment, its cytotoxicity by MTT method, its cytocompatibility by in vitro culture method and coagulation by PT. Enzyme time, TT thrombin time and APTT activated partial thromboplastin time were used to detect its coagulation effect.

[0043] In the present invention, the simulated body fluid degradation test is carried out on the vascular ligation clip, and it is found that to make the vascular ligation clip have a longer degradation time, the molecular weight of the polymer should be correspondingly...

Embodiment

[0048] Hereinafter, an embodiment of the present invention will be specifically described by showing examples and comparative examples. However, the present invention is not limited to the following examples.

[0049] (Synthesis of Aliphatic Polyester Materials)

Synthetic example 1

[0050] Synthetic example 1 to the preparation of dioxanone-glutamic acid copolymer 1

[0051] The two monomers of p-dioxanone and glutamic acid were mixed in a molar ratio of 70:30, weighed 300g and added to the reactor, and 0.02% stannous octoate catalyst was added to the reactor. The reaction system was sealed, and nitrogen gas was introduced to protect the reaction. The temperature of the reaction system was controlled at 120° C., and the reaction was carried out for 10 hours. The reactants were chopped to make pellets with a particle size of 1-8 mm, and 191 g of pellets were obtained by weighing, with a yield of 95.5%. The above pellets were dissolved in a phenol / tetrachloroethane (2:3 / V:V) mixed solution, and the intrinsic viscosity of the copolymer was measured as 3.28dL / g with an Ubbelohde viscometer in a constant temperature water bath at 25°C.

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Abstract

The invention provides an absorbable vessel ligature clamp for surgical operation and a preparation method thereof. The vessel ligature clamp is prepared from a biodegradable aliphatic polyester material, wherein the biodegradable aliphatic polyester material is a homopolymer of any one of monomers or a copolymer of any two type of monomers, namely dioxanone, glycolide, lactide, caprolactone and trimethylene carbonate, and the vessel ligature clamp can be prepared by virtue of the modification and injection molding of amino acid. The vessel ligature clamp is good in biocompatibility, adjustable in degradation time, and capable of being matched with the vessel healing period after the surgical operation.

Description

technical field [0001] The invention relates to a surgical bioabsorbable blood vessel ligation clip prepared from raw materials containing biodegradable aliphatic polyester materials. In detail, it relates to a biodegradable aliphatic polyester material with excellent biocompatibility and adjustable degradation time in the body, and a biodegradable biomaterial for surgery with flexibility, good clamping force and optimized structure prepared therefrom. Absorbable vascular ligation clips. In addition, the present invention also relates to a preparation method of the blood vessel ligation clip. Background technique [0002] Hemostasis technology is one of the cores of basic surgical techniques. Surgical operations on any part of the human body almost without exception involve bleeding and hemostasis. , equipment, anesthesia, etc., including a complete technical system. Finding the bleeding site and treating the bleeding vessels is the real key to stop bleeding. Traditional...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/14B29C45/76
Inventor 张洁裴明黎张晓蕾郑海菁
Owner HANGZHOU MEDZONE BIO-TECH CO LTD
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