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Calcium phosphate polymer composite and method

a calcium phosphate and composite technology, applied in the field of mineral polymer composites, can solve the problems of unidirectional or multidirectional bone-repair composites

Inactive Publication Date: 2007-11-01
TELEFLEX MEDICAL INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0212] The many features and advantages of the invention are apparent from the detailed specification, and thus, it is intended by the appended claims to cover all such features and advantages of the invention which fall within the true spirit and scope of the invention. Further, since numerous modifications and variations will readily occur to those skilled in the art, it is not desired to limit the invention to the exact construction and operation illustrated and described, and accordingly, all suitable modifications and equivalents may be resorted to, falling within the scope of the invention.

Problems solved by technology

The bone-repair composite is unidirectional or multidirectional.

Method used

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  • Calcium phosphate polymer composite and method

Examples

Experimental program
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Effect test

example

[0053] CaP Coating on Fully Drawn PLA Yarn

[0054] Commercially available poly-lactic acid (PLA) yarn (Mw˜121 kDa, Tg˜55° C., Tm˜175° C.) was obtained from Teleflex Medical Incorporated. Each yarn contained about 30 filaments, with the filaments having an average diameter of 24.5 μm. The PLA yarn was wound around a rectangular, using a custom-built winding machine that allowed for the control of winding speed and tension. During this stage, care was taken to avoid overlapping of the yarn on the frame. A linear spinning rate of 20 cm / min and a tension of approximately 6 N were used for all the experiments. The yarn was then soaked in 1 N NaOH for 1 min. at 25° C. to saponify the surfaces of fibers. The soaked yarn was rinsed in distilled water and air-dried.

[0055] The saponification process was checked in several ways. In one test, water contact angles of the treated PLA films were measured by the sessile drop technique (advancing angles) using a contact angle measurement apparatus (...

example 1

[0137] Drawn PLA fiber yarn (30 filament, 120 denier) was wound around open plastic frames (21 / 4×11 / 8 in.). The amount of fiber on each frame varied since the process was done by hand. The fiber and frame were then weighed. The samples were then soaked in simulated body fluid solution (3× concentration) for 12 h to generate a layer of hydroxyapatite (HA) coating on the surface of the PLA fibers. The samples were left to dry overnight. After drying the weight was recorded and was used to calculate the percentage of HA by weight of each sample. The samples were then hot compacted into bars with dimensions around (4×0.5×0.2) cm at a temperature of 175° C. for 30 min. Afterwards, each sample was subjected to a three-point bend test to determine flexural modulus and flexural strength. This was done at a strain rate of 1 mm / min. It is noted that etching is not used in this example. Nonetheless, etching can be used prior to biomimetic coating. Also, a low temperature binding sheath was not...

example 2

[0145] Direct Coating of Calcium Phosphate Precursors

[0146] Pre-formed or calcium phosphate precurors can be directly coated onto PLA fibers. A hydrothermal method is used to make the HA, then the particles are used with PCL to coat over the fibers. In addition, other calcium phosphates can be used.

[0147] The HA particles used in the composite were prepared by reacting of 200 mL calcium nitrate solution (2 g / dL) and 600 mL ammonium phosphate solution (2 g / dL). After drying, the precipitate was ground into powder, which has an average particle size of 120 nm and is shown in FIG. 19. Ten mg of ground HA powder was then added into 10 mL PCL (Dow, MW 80,000) acetone solution (1% wt / wt), which was used to dip-coat the PLA fiber strand composed of 30 fibers with a 22-μm diameter for each fiber. Sixty meters of PCL-HA coated PLA fibers were then aligned and hot-pressed in a 40-mm×5-mm×2-mm mold at 80° C. for 4 min. The resulting composite was taken out after cooling and its composition w...

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Abstract

A bone-repair composite includes a core and a sheath. The core is a first primary unit including a combination of a first set of yarns coated with a calcium phosphate mineral layer. The first set of yarns being made from a first group of one ore more polymers. The sheath is a second primary unit a combination of a second set of yarns or one or more polymer coatings. The second set of yarns being made from a second group of one or more polymers, wherein the composite is made by covering the core with the sheath, and the composite is compression molded to allow the sheath to bond to the core. The bone-repair composite has a bending modulus comparable to that of a mammalian bone, such that the ratio of the core to the sheath is provided to maximize the mechanical strength of the bone-repair composite to mimic the mammalian bone.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims priority to provisional U.S. patent application entitled, “CALCIUM PHOSPHATE POLYMER COMPOSITE,” filed Apr. 25, 2006, having a Ser. No. 60 / 794,518, now pending, the disclosure of which is hereby incorporated by reference, in its entirety.FIELD OF THE INVENTION [0002] The present invention relates generally to biomaterials for bone replacement. More particularly, the present invention relates to a mineral polymer composite. BACKGROUND OF THE INVENTION [0003] Over 10 million Americans carry at least one major implanted medical device in their body. Among these implants, bone fracture and damage cases constitute a large proportion, and result in more than 1.3 million bone-repair procedures per year in the USA. In general, bone tissue has the capability of postnatal self-construction. However, in severe pathological situations such as complicated fractures, trauma, bone tumors, congenital defects or spinal fusion, th...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F2/28
CPCA61F2/28A61L2430/02A61F2/3094A61F2/30965A61F2/468A61F2002/2817A61F2002/30032A61F2002/30062A61F2002/30224A61F2002/30235A61F2002/30293A61F2002/30677A61F2002/30914A61F2002/30957A61F2210/0004A61F2230/0069A61F2230/0091A61F2250/003A61F2310/00293A61F2310/00365A61F2310/00796A61L27/20A61L27/425A61F2/30767C08L5/08A61L27/46
Inventor WEI, MEIOLSON, JAMESSHAW, MONTGOMERY
Owner TELEFLEX MEDICAL INC
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