Method for preparing cucurbituril and cucurbituril derivative

A technology of cucurbituril and derivatives, which is applied in the field of preparation of cucurbituril and cucurbituril derivatives, can solve the problems of corrosiveness, high equipment requirements, environmental pollution, etc., and achieve strong corrosiveness, serious acid pollution, and low yield Effect
CN104016994AInactive Publication Date: 2014-09-03DALIAN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
DALIAN UNIV OF TECH
Publication Date
2014-09-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of organic synthesis and chemical engineering, which relates to a method for preparing cucurbituril and a cucurbituril derivative. The method comprises the following steps: carrying out a mixed reaction on a glycoluril-aldehyde polymer, an acidic ionic liquid and a solvent or carrying out the mixed reaction on glycoluril, aldehyde, the acidic ionic liquid and the solvent for 1 second to 300 hours at a reaction temperature of 0 DEG C to 300 DEG C; and standing a reaction liquid and cooling after the reaction, thereby separating out the cucurbituril or the cucurbituril derivative in a crystallization manner; or adding an organic solvent after the cooling of the reaction liquid, thereby separating out the cucurbituril or the cucurbituril derivative in a precipitation manner. Compared with the background technology which is strong in corrosivity, serious in acid pollution and low in yield, the synthesis process provided by the invention is environmental friendly, economical and efficient, and has the advantages that the acidic ionic liquid is used for replacing the traditional inorganic strong acid to serve as a catalyst, thereby being environmental friendly; the acidic ionic liquid can be recycled, thereby being economical; the microwave radiation is optimally adopted as a heat source, thereby being efficient.
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Description

technical field

[0001] The invention belongs to the field of organic synthesis and chemical industry, and relates to a method for preparing cucurbituril and cucurbituril derivatives. Background technique

[0002] In 1905, R. Behrend et al. found that glycoluril-formaldehyde polymers could generate macrocyclic compounds of unknown structure after treatment with concentrated sulfuric acid (Liebigs Ann. Chem. 1905, 1, 339). In 1981, W. Mock et al. repeated the experiment, and analyzed the macrocyclic compound by X-ray single crystal diffraction to be a cyclic hexamer connected by glycoluril through a methylene group, named cucurbit [6] urea (J.Am. Chem. Soc. 1981, 103, 7367). At present, cucurbituril (CB) has been used in many fields such as drug delivery, catalyst, molecular machine, sensor, ion channel, and wastewater treatment.

[0003] In traditional CB[n] synthesis methods, strong inorganic acids (such as concentrated sulfuric acid and concentrated hydrochloric acid) are...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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