Method for preparing polymer containing cucurbituril structure

A polymer, cucurbituril technology, applied in the field of polymer preparation, can solve the problems of poor solubility of cucurbituril, difficulty in functionalization of cucurbituril, etc., and achieve the effect of good biocompatibility, excellent performance, and good recognition ability

Active Publication Date: 2014-10-08
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the difficulty in the functionalization of cucurbituril and the poor solubility of cucurbituril, polymers containing cucurbituril structures have not been reported.

Method used

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  • Method for preparing polymer containing cucurbituril structure
  • Method for preparing polymer containing cucurbituril structure
  • Method for preparing polymer containing cucurbituril structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Preparation of polymers containing cucurbit [7] urea structure:

[0057] (1) Cucurbit[7]urea 0.5g was dispersed in 50mL ultrapure water, and 0.2g of 3,3'-(1,8-dioctamethylene)-bis-(1-ethylimidazole)dibromide was added at 50 Heat and stir at ℃ for 30 minutes to form a homogeneous solution;

[0058] (2) After the homogeneous solution obtained in step (1) was bubbled with nitrogen for 15 minutes, 0.12 g of ammonium persulfate was added, and heated to 85°C for oxidation reaction; Resin chromatography column separation, obtains compound 0.142g shown in formula (II);

[0059] (3) 0.1 g of the compound shown in formula (II) was dissolved in 30 mL dimethyl sulfoxide, 0.05 g of sodium hydride was added at 0° C., and reacted for 5 h; then 0.2 g of 4-vinyl chloride was added, and reacted for 16 h; after the reaction, Add ether to precipitate the product, and wash it with methanol to obtain the complex of 4-vinylbenyloxycucurbituril and 3,3'-(1,8-dioctamethylene)-bis-(1-ethylimid...

Embodiment 2

[0071] As described in Example 1, the difference is that the 4-vinylbenyloxycucurbit[7]urea in step (5) is 0.2 g, the water is 30 mL, and the 3,3'-(1,8-dioctyl )-bis-(1-ethylimidazole) dibromide 0.10g; in step (6), the monomer was changed to 1.2g acrylamide, and the initiator was 0.005g ammonium persulfate and 0.0024g sodium bisulfite.

Embodiment 3

[0073] As described in Example 1, the difference is that the 4-vinylbenyloxycucurbit[7]urea in step (5) is 0.1 g, the water is 20 mL, and the 3,3'-(1,8-dioctyl )-bis-(1-ethylimidazole) dibromide 0.04g; in step (6), the monomer was changed to 0.5g acrylamide, and the initiator was 0.003g ammonium persulfate and 0.0015g sodium bisulfite.

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Abstract

The invention discloses a method for preparing a polymer containing a cucurbituril structure. The method comprises the following steps of oxidizing cucurbituril by virtue of persulfate to obtain hydroxyl cucurbituril, further reacting hydroxyl cucurbituril to obtain polymerizable cucurbituril monomer and copolymerizing with other water-soluble monomers by virtue of free radical polymerization to obtain the polymer containing a cucurbituril structure. Since the cucurbituril unit is introduced into the middle side chain of the macromolecule, compared with the conventional polymer or the similar host molecule functionalized polymer, the polymer disclosed by the invention has the advantages of relatively strong binding capacity, better identification capability, relatively high chemical stability and good biocompatibility. The polymer has broad application prospects in the fields of medicine, biomaterials, cosmetic, analysis and the like.

Description

technical field [0001] The invention relates to a preparation method of a polymer, in particular to a preparation method of a polymer containing a cucurbituril structure, in particular to a preparation method of a side chain cucurbituril-functionalized polymer, belonging to macromolecular chemistry and polymer technology field. Background technique [0002] The side chain cucurbituril functionalized polymer refers to a type of polymer that introduces a cucurbituril structure on the side chain of the polymer. Domestically and internationally, polymers with such a structure have not been reported yet. Polymers with side chains containing other host molecules have been reported, which have low biotoxicity, good biocompatibility, selective recognition ability, good drug transport and loading capacity, and are used in biogels, drug delivery and Controlled release, drug targeting, and protein recognition and separation have broad application prospects. [0003] Compared with ot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/14C08F220/54C08F220/56C08F8/00
Inventor 谭业邦陈浩马海俐侯胜珍
Owner SHANDONG UNIV
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