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Traditional Chinese medicine active part for preventing chronic pelvic inflammation, and preparation method and applications thereof

A technology of chronic pelvic inflammatory disease and effective parts, applied in the field of effective parts of traditional Chinese medicine for the prevention and treatment of chronic pelvic inflammatory disease and its preparation, can solve problems such as difficulty in effective control of drug stability, imperfect control of quality standards, and unclear material basis of drug efficacy. To achieve the effect of good patient compliance, safe use, and clear active ingredients

Active Publication Date: 2017-03-15
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the original preparations for the treatment of chronic pelvic inflammatory disease (CPID) in the market have disadvantages such as unclear drug substance basis, unclear active ingredients, imperfect quality standard control, difficult to effectively control drug stability, and large clinical doses.

Method used

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  • Traditional Chinese medicine active part for preventing chronic pelvic inflammation, and preparation method and applications thereof
  • Traditional Chinese medicine active part for preventing chronic pelvic inflammation, and preparation method and applications thereof
  • Traditional Chinese medicine active part for preventing chronic pelvic inflammation, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 prevents and treats the Chinese medicine effective part preparation (tablet) of chronic pelvic inflammatory disease

[0030] The effective part of the traditional Chinese medicine for preventing and treating chronic pelvic inflammatory disease in this embodiment includes the following components in terms of weight percentage: 12.23% astilbin, 6.82% astilbin, 10.39% isoastilbin, 17.39% astilbin, 17.32% astilagin, 5% diosgenin.

[0031] The preparation method of the effective part preparation of traditional Chinese medicine for preventing and treating chronic pelvic inflammatory disease of the present embodiment, comprises the following steps:

[0032] (1), 5 kg of the rhizome of Smilax smilax was crushed into coarse powder, and the crushed medicinal material was reflux extracted with 95% ethanol for 3 times, boiled for 1 hour each time, the extracts were filtered and combined, concentrated under reduced pressure until no alcohol smell, to obtain a concentrat...

Embodiment 2

[0038] The Chinese medicine effective part preparation (capsule) of embodiment 2 prevention and treatment of chronic pelvic inflammatory disease

[0039] The effective parts of the traditional Chinese medicine for preventing and treating chronic pelvic inflammatory disease in this embodiment include the following components in terms of weight percentage: 8.37% astilbin, 4.52% astilbin, 15.90% isoastilbin, 22.65% astilbin, 15.66% astilagin, 3.75% diosgenin.

[0040] The preparation method of the effective part preparation of preventing and treating chronic pelvic inflammatory disease of the present embodiment, comprises the following steps:

[0041](1) 5 kg of the rhizome of Smilax smilax was crushed into a coarse powder, and the crushed medicinal material was reflux extracted with 75% ethanol for 3 times, boiled for 1 hour each time, the extracts were filtered and combined, concentrated under reduced pressure until no alcohol smell, to obtain a concentrate;

[0042] (2), take...

Embodiment 3

[0047] The Chinese medicine effective part preparation (injection) of embodiment 3 prevention and treatment of chronic pelvic inflammatory disease

[0048] The effective part of the traditional Chinese medicine for preventing and treating chronic pelvic inflammatory disease in this embodiment includes the following components in terms of weight percentage: astilbin 16.11%, new astilbin 12.55%, isoastilbin 6.97%, new different 15.47% astilbin, 24.97% astilagin, 7.15% diosgenin.

[0049] The preparation method of the effective part preparation of traditional Chinese medicine for preventing and treating chronic pelvic inflammatory disease of the present embodiment, comprises the following steps:

[0050] (1), 5 kg of the rhizome of Smilax smilax was crushed into coarse powder, and the crushed medicinal material was reflux extracted with 95% ethanol for 3 times, boiled for 1 hour each time, the extracts were filtered and combined, concentrated under reduced pressure until no alcoh...

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Abstract

The invention discloses a traditional Chinese medicine active part for preventing chronic pelvic inflammation, and a preparation method and applications thereof. The content of the traditional Chinese medicine active part is 50-90%, and the traditional Chinese medicine active part comprises the following components in percentage by weight: 8.37-16.11% of astilbin, 4.52-12.55% of neoastilbin, 6.97-15.90% of isoastilbin, 15.47-22.65% of neoisoastilbin, 15.66-24.97% of engeletin and 3.75-7.15% of gracillin. The traditional Chinese medicine active part preparation for preventing chronic pelvic inflammation is prepared by combining smilax china flavonoid compound and saponin according to certain proportions, the curative effect is definite, the active ingredients are clear, and the traditional Chinese medicine active part has the efficacies of clearing away heat and toxic materials and invigorating blood circulation to remove blood stasis, is effectively used for preventing chronic pelvic inflammation, and is safe to use, convenient to take, small in dose and good in compliance of patients.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and more specifically, the invention relates to an effective part of traditional Chinese medicine for preventing and treating chronic pelvic inflammatory disease, a preparation method and application thereof. Background technique [0002] Smilax is the dried rhizome of Smilax China L., a plant of Liliaceae. Also known as King Kongteng, it is a traditional Chinese medicine. The 2005 edition of "Chinese Pharmacopoeia" records that Sarsaparilla has the effect of dispelling wind and dampness, detoxifying and dispelling blood stasis. . In addition to treating gynecological diseases, traditional Chinese medicine is also used to treat tumors and has achieved good results. [0003] There are many studies on the phytochemical constituents of Smilax genus. Up to now, more than 80 compounds have been isolated from this genus, including flavonoids, steroidal saponins, amin...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61K36/896A61P15/00A61K31/7048
Inventor 侯连兵宋路瑶谢扬冯海兴刘文钦
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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