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Method of quality control for smilax china

A quality control method and technology for sarsaparilla, applied in the quality control of sarsaparilla and the quality control of traditional Chinese medicine preparations, can solve the problems of poor specificity, cumbersome operation, poor controllability, etc., and achieve convenient operation, comprehensive and more accurate quality, good quality The effect of specificity and quality correlation

Active Publication Date: 2009-10-07
GUILIN SANJIN PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The presence of a large amount of cellulose and starch in Smilax medicinal materials interferes with hydrolysis, so the yield of diosgenin is low, which has a great impact on the determination of Smilax, and also affects the accuracy of Smilax content determination. Considering that diosgenin is a hydrolyzate, the current pharmaceutical technical regulations do not advocate the use of hydrolyzate as an indicator for content determination. In actual inspection operations, it is found that the above method has poor specificity, cumbersome operation, poor controllability, and poor stability of content determination results, etc. Insufficient, affecting the generalizability of the standard

Method used

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  • Method of quality control for smilax china
  • Method of quality control for smilax china

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] [Example 1] Determination of content of Smilax smilax

[0034] (1) measure according to high performance liquid chromatography (an appendix VID of Chinese Pharmacopoeia edition in 2005), chromatographic conditions and system suitability test, use C 18 or C 8 (octadecylsilane bonded silica gel or octadecylsilane bonded silica gel) is used as filler; methanol-0.1% phosphoric acid solution with a ratio of 35:65 is used as mobile phase; detection wavelength is 290nm; column temperature is 35°C; theoretical The number of plates should not be less than 5000 based on the peak of astilbin;

[0035] (2) Preparation of reference substance solution, accurately weigh 2 mg of astilbin reference substance and 2 mg of astilbin reference substance, put them in a 100ml measuring bottle, add methanol to the mark, shake well, and each 1ml contains astilbin respectively A mixed solution of 20 μg and 20 μg of basaltine;

[0036] (3) Accurately weigh 1g of sarsaparilla powder, put it in a...

Embodiment 2

[0038] [Example 2] Determination of content of Smilax smilax

[0039] The specific operation steps are the same as in Example 1, except that the methanol-0.1% phosphoric acid solution with a ratio of 30: 70 is the mobile phase in the step (1); the detection wavelength is 280nm; in the step (3), ultrasonic treatment (power 250W, frequency 40kHz) for 30 minutes.

Embodiment 3

[0040] [Example 3] Determination of content of Smilax smilax

[0041] The specific operation steps are the same as in Example 1, except that in step (1), methanol-0.1% phosphoric acid solution with a ratio of 40:60 is used as the mobile phase.

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Abstract

The invention discloses a method of quality control for smilax china. In the method, the content of the smilax china is measured by using C18 or C8 as a filler; methanol- 0.1 percent of phosphoric acid solution with the proportion of 25-45 : 55-75 or acetonitrile- of 0.1 percent of phosphoric acid solution with the proportion of 10-20 : 80-90 or acetonitrile-the methanol-0.1 percent of phosphoric acid solution with the proportion of 0-10: 10-30 : 60-90 as a moving phase;, and using a detection wavelength ranging from 280 nm to 300 nm. Astilbin contained in the smilax china cannot be less than 0.030 percent, and engelitin contained in the smilax china cannot be less than 0.030 percent. The method of quality control for the smilax china is efficient, stable and accurate and has convenient operation and strong specialization, and can well control the quality of the smilax china or a preparation containing smilax china raw materials.

Description

technical field [0001] The invention relates to a quality control method of Chinese medicinal materials, in particular to a quality control method of smilax, and also includes a quality control method of a traditional Chinese medicine preparation containing smilax as a raw material. Background technique [0002] Smilax is Liliaceae plants Smilax China L., S. ferox Wall.ex Kunth, S. glauco-china Warb., S. discotis Warb.), S. davidiana A.DC, S.biumbellata Warb., S.chingiiWang et Tang, S. polycolea Warb. ) and other dried rhizomes of plants. Excavated from late autumn to next spring, removed fibrous roots, washed, dried in the sun or sliced ​​while fresh, and dried. Sweet in taste, slightly bitter, flat in nature, returns to Liver and Kidney Meridians. Traditional medicine believes that its rhizome has medicinal value, has the effect of dispelling wind and dampness, detoxifying and dispelling blood stasis, and can be used to treat muscle and bone pain, profuse urination, pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896G01N30/36G01N30/50
Inventor 邹节明
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD
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