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Process for the synchronization of ovulation for timed breeding without heat detection

a technology of synchronization and ovulation, applied in the field of reproductive management, can solve the problems of not being able to predict the day of heat, not being able to produce and not being able to achieve high fertilization rates and viable embryos

Active Publication Date: 2005-06-16
THORN BIOSCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009] Examples demonstrate that the method of synchronization was highly effectiv

Problems solved by technology

FSH-P has a fairly high and variable content of luteinizing hormone and while effective in producing an ovulatory response, has been less than desirable in producing high fertilization rates and viable embryos.
Part of the production costs is the result of a heavy reliance on daily heat detection of individual animals (W. L. Flowers and H.-D.
Rigorous heat detection is necessary because it is difficult to predict the day of heat for any cyclic gilt or open sow, even with good heat detection records.

Method used

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  • Process for the synchronization of ovulation for timed breeding without heat detection

Examples

Experimental program
Comparison scheme
Effect test

example 1

Treatment with a Single Dose of Hormone Yielded Higher Litter Sizes

[0031] A dose response study was performed using deslorelin in SAIB in an ovariectomized estrogen primed gilt model (Barb, et al. (1999) Proceed. Int'l. Symp. Control. Rel. Bioact. Mater., 26). As shown in FIG. 1a, 50 mcg of deslorelin in SAIB produced a LH peak about twice normal value, compared to Hansel et al., (1973) Biology of Reproduction 8, 222) FIG. 1b, which returned to base level by 18 hours as determined by RIA.

example 2

Comparison of Intravulvular Administration with Injection of Deslorelin

[0032] Based on these results a study was performed utilizing mature postpartum sows with 75 test individuals and 75 controls. Sows were assigned randomly in blocks of two to either control or to be injected intravulvar with 50 mcg of deslorelin in SAIB at the time of estrus detection for sows first detected in estrus in the a.m. and 12 hours later for those first detected in estrus in the p.m. Treated animals were bred AI upon detected estrus and again 24 hours later if still in estrus. Controls received a saline injection on first detected estrus behavior estrus detection and were bred according to the farm's normal procedures.

[0033] As shown in Table 1, there was no significant difference in pregnancy rates for sows of the Control versus Treated groups but there were 0.6 greater number of live piglets born per litter in the treated group versus control group.

TABLE 1Estrus and Pregnancy Rates After Deslorel...

example 3

Normal Pregnancy Rates were Attained Following Hormone Treatment in Sows

[0034] Approximately 170 postpartum sows were randomly divided into two equal groups comprised of controls and treated. Following weaning, the controls were detected for estrus and bred following the normal standard operating procedures for the farms on which they resided. The treated sows received a 50 mcg dose of deslorelin in SAIB at 96 hours post-weaning and were bred with a single insemination 28+ / −2 hours later with no regard to estrus detection. The sows were examined for pregnancy by ultrasound at 21 days and slaughtered around 28 days post breeding. The entire reproductive tract was removed and corpora lutea and embryos were counted.

[0035] The data in Table 2 demonstrates that normal pregnancy rates were attained following a single timed injection of deslorelin in SAIB, at a timed interval post-weaning, followed by a single timed insemination, in the absence of any estrus (heat) detection.

TABLE 2Pre...

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Abstract

A method for synchronizing ovulation in sows and gilts by a single injection of hormones is disclosed. A hormone, gonadotropin releasing hormone (GnRH), luteinizing hormone (LH), follicle stimulating hormone (FSH), human chorionic gonadotropin (hCG), analogues, derivatives, agonists or combinations thereof is administered to an open sow post weaning at a specific time to stimulate ovulation of mature responsive follicles. The sow is then bred, without heat detection, at a specific subsequent timed interval after injection with hormone, with one or two artificial or natural breedings. In gilts, the hormone is injected at a timed interval from onset of estrus or at a specific timed interval following Prostaglandin F2a for those gilts which have been held in a state of pseudopregnancy.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application claims priority to U.S. Ser. No. 60 / 508,509 filed Oct. 3, 2003 entitled “Process for the Synchronization of Ovulation for Timed Breeding Without Heat Detection” by James W. Lauderdale.FIELD OF THE INVENTION [0002] This invention relates to the reproductive management of sows and gilts and more particularly processes for synchronizing ovulation in such swine for timed artificial breeding with a reduction in or with no regard to estrus detection. BACKGROUND OF THE INVENTION [0003] The administration of hormones to control the reproductive process in domestic animals such as horse, cows, sheep, goats and swine is well known in the art. One approach to managing reproductive processes in domestic mammals involves the direct administration of gonadotropins to domestic animals. Gonadotropins are produced by the anterior lobe of the pituitary gland and are characterized as follicle stimulating hormone (FSH) and luteinizing horm...

Claims

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Application Information

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IPC IPC(8): A61K38/09A61K38/24C12N
CPCA61K9/0034A61K9/08A61K9/10A61K9/0019A61K38/24A61D19/02A61K38/09A61P15/08A61K9/06
Inventor LAUDERDALE, JAMES W.
Owner THORN BIOSCI
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