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System for assessing ovarian reserve functions in subjects

A technology for ovarian reserve and subjects, applied in biological tests, complex mathematical operations, health index calculations, etc.

Active Publication Date: 2019-04-12
GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In short, none of the ovarian reserve indicators can be used alone for the diagnosis of ovarian reserve decline, and it needs to be further clarified in combination with other methods

Method used

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  • System for assessing ovarian reserve functions in subjects
  • System for assessing ovarian reserve functions in subjects
  • System for assessing ovarian reserve functions in subjects

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Experimental program
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Embodiment

[0113] In the embodiment, the sample size is estimated first, the total sample size should be >553, and all couples are trying to conceive for at least 12 months.

[0114] According to the following inclusion and exclusion criteria, a total of 561 couples were enrolled in the three reproductive medicine centers for this study, that is, 561 couples who met the following inclusion and exclusion criteria were selected for subsequent research.

[0115] Inclusion criteria were: women aged 20 to 45 years, body mass index (BMI) ≤ 30, six consecutive menstrual cycles of 25 to 45 days, normal bilateral ovarian morphology assessed by vaginal ultrasonography, previous IVF / ICSI- ET cycle number ≤ 2.

[0116] The exclusion criteria were: hydrosalpinx, unilateral ovary AFC>20, polycystic ovary syndrome, other untreated metabolic or endocrine diseases, previous surgery for the ovary or uterine cavity, intrauterine abnormalities, pregnancy within 3 months, Smoking, using oral contraceptives ...

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Abstract

The present invention relates to a system for assessing ovarian reserve functions in subjects. The system for assessing the ovarian reserve functions of the subjects comprises a data acquisition module used for obtaining data of a subject's age, an anti-Mullerian hormone (AMH) level, a follicle stimulating hormone (FSH) level and antral follicle counting (AFC); and a module for calculating the ovarian reserve functions used for calculating information obtained in the data acquisition module to calculate a probability (p) of subject's ovarian hyporesponsiveness. Further, a relationship betweenthe predicted ovarian hyporesponsiveness probability and a medicine dose of an ovulation-promoting medicine is predicted to divide populations into four groups in order to group closes ovarian responsiveness into one group.

Description

technical field [0001] The present invention relates to a system for evaluating the ovarian reserve function of a test subject. The system can be used to assess the condition of the test subject's own ovarian reserve function, to assess its fertility potential, and to assess the test subject after undergoing corresponding Whether fertility potential improves after treatment. Background technique [0002] The number of primordial follicles contained in the ovarian cortex is called the ovarian reserve. It reflects the ability of the ovary to provide healthy eggs that can be fertilized successfully, and is the most important evaluation index of female ovarian function. Generally speaking, the greater the number of primordial follicles, the better the quality and the higher the chance of conception. [0003] Evaluation of ovarian reserve function can help women of childbearing age understand their fertility status so that they can reasonably arrange their own family planning. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B8/00G01N33/74G01N33/76
CPCA61B5/4325G01N33/74G01N33/76A61B5/7271A61B8/00A61B5/7275G01N33/689G16H50/30A61B8/0866A61B8/12A61B8/5223A61B8/4416G06F17/18
Inventor 李蓉徐慧玉乔杰
Owner GUANGZHOU KANGRUN BIOTECHNOLOGY CO LTD
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