42 results about "Necrospermia" patented technology

The invention belongs to the technical field of traditional Chinese medicines, in particular discloses a Chinese medicinal composition for treating necrospermia, asthenospermia oligospermia, or aspermatism, which comprises the following raw material medicaments in part by weight: 10 to 20 parts of epimedium brevicornum, 10 to 20 parts of medicinal indianmulberry root, 10 to 20 parts of desertliving cistanche, 10 to 20 parts of south dodder seed, 10 to 20 parts of siberian solomonseal rhizome, 10 to 20 parts of Chinese angelica, 7 to 13 parts of common curculigo rhizome, 8 to 16 parts of Chinese thorowax root, 8 to 16 parts of large-headed atractylodes rhizome, 14 to 26 parts of astragalus, 14 to 26 parts of radix rehmanniae praeparata, 14 to 26 parts of dioscorea root, 3 to 8 parts of liquorice root, 5 to 13 parts of glossy privet fruit, 10 to 20 parts of plantain seed, 10 to 20 parts of palmleaf raspberry fruit, 20 to 40 parts of root of red-rooted salvia, 8 to 16 parts of eucommia bark, 7 to 13 parts of baicalin, 3 to 8 parts of salivia chinensis, 6 to 13 parts of Indian buead and 6 to 14 parts of oriental waterplantain rhizome. The Chinese medicinal composition has the effects of warming and invigorating kidney yang with tonifying qi and invigorating blood circulation and supplementing essence and replenishing marrow, and has the advantages of simple preparation, convenient administration, good curative effect and no toxic or side effect.

The invention discloses in vitro human sperm culture solution for improving sperm motility and application thereof. The culture solution contains fructose 6-phosphoric acid (F6P). The in vitro human sperm culture solution for improving the sperm motility of human sperms is used for culturing the purified human sperms which leave from a human body; the vitality of normal human sperms is capable of maintaining sperm movement and can be obviously improved; and a meaningful reference is provided for improving and assisting the reproductive technology. The F6P is directly used for cultivating and diluting the culture solution, and does not relate to organic solvents such as ethanol or dimethylsulfoxide (DMSO) and the like; the toxic action of the ethanol or the DMSO on the sperms is avoided; by adopting the F6P added to the sperm culture solution, the vitality of the sperms of clinical patients with asthenospermia can be obviously improved; the improvement degree of the vitality is the most obvious for severe oligospermia; the activity of a part of cultured sperms reaches the normal sperm vitality range; and the improvement degree of the vitality for the severe oligospermia is the most obvious. This fully demonstrates that low motility of the sperms of the patients with asthenospermia can be improved by using of the F6P.

The invention relates to a medicinal composition for treating impotence and premature ejaculation. The medicinal composition consists of the following bulk pharmaceuticals in parts by weight: 500-2,000 parts of desertliving cistanche, 200-1,000 parts of cynomorium coccineum, 200-1,000 parts of barbary wolfberry fruit, 50-150 parts of Chinese magnoliavine fruit, 50-300 parts of plantain seed and 200-1,000 parts of south dodder seed. The medicinal composition has the effects of tonifying the kidney to arrest spontaneous emission, invigorating qi, nourishing yin, stopping emission, warming kidney and invigorating the spleen, is prepared from pure Chinese medicines, is free from side effects, has a remarkable curative effect, and is mainly used for treating impotence, premature ejaculation, deficiency in semen, necrospermia, man and woman frigidity, functional sterility, hypogenesis of internal and external genitals, lack of vitality, reduction in tolerance and the like. As proved by clinical use on 450 cases, 392 cases are cured, apparent effects are achieved on 423 cases, and effective effects are achieved on 443 cases. Moreover, the treatment cost is low, and the treatment period is short and generally lasts for 12-15 days as a treatment course.

The present invention relates to uses of icariside II, particularly to uses of icariside II in preparation of products for prevention or treatment of reproduction dysfunction, prevention and/or treatment of abnormal semen quality, prevention and/or treatment of sterility caused by clinical oligospermia, asthenospermia, teratozoospermia or oligospermia-asthenospermia-teratozoospermia triad, or improvement of sperm amount and/or sperm motility.

The invention relates to a Chinese herbal medicine preparation for curing the endometrial disease, the infertility and the habitual abortion. The Chinese herbal medicine preparation is prepared through decocting the following Chinese herbal medicines with water: angelica sinensis, astragalus membranaceus, rubus idaeus, ciliatenerve knotweed root, spiranthes sinensis ames, polygonum perfoliatum, kalimeris indica root, herba lycopi, achyranthes aspera, ginseng, rubus pluribracteatus, rubus parvifolius root, rhizoma polygonat, solanum lyratum, cyperus rotundus, cistanche, daughters red, crneate lespedeza, Chinese rose, galium aparine, achyranthes root, sagina subulata, gold rattan, crowndaisy chrysanthemum, herba leonuri, sargentgloryvine stem, semen cuscutae, semen euryales and the like. The Chinese herbal medicine preparation is beneficial for the recovery of the physical function and the organ function, has no any toxic or side effects, achieves more than 93% of effective rate in treating the female infertility and the habitual abortion, achieves more than 94% of effective rate in treating the endometritis and the pelvic inflammation, achieves more than 89.4% of effective rate in treating the cervical hypertrophy, the cervical erosion, the xeromenia, the inflammatory mass, the uterine fibroid, the ovarian cyst and other gynecological diseases, and achieves more than 94.1% of effective rate in treating sterility due to oligozoospermia and the necrospermia.

The invention provides a traditional Chinese medicine composition for treating male infertility and a preparation process thereof, and relates to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition for treating male infertility comprises the following raw materials in parts by weight: 12 to 22 parts of spermatogenesis promoting component, 6 to 12 parts of alpha receptor blocker component, 10 to 20 parts of sperm active component, 6 to 12 parts of semen cuscutae, 5 to 12 parts of herba cistanche, 6 to 20 parts of fructus lycii, 6 to 12 parts of fructus corni, 1 to 5 parts of cornu cervi pantotrichum and 5 to 10 parts of herba cynomorii. The traditional Chinese medicine composition for treating male infertility has an excellent treatment effect on infertility caused by male oligospermia and asthenospermia, and has extremely small side effects. In addition, the invention further provides a preparation process of the traditional Chinese medicine composition for treating male infertility. Effective substances of all the components of the traditional Chinese medicine composition for treating male infertility are extracted through the process, the effective components are reserved, and the treatment effect is improved.

The invention provides kidney-tonifying and essence-strengthening soup. The kidney-tonifying and essence-strengthening soup has the functions of tonifying kidney qi, activating blood and strengthening essence, is mainly used for treating necrospermia caused by kidney essence depletion and poor qi and blood and has excellent effect. The kidney-tonifying and essence-strengthening soup is prepared from the following raw material medicines in parts by weight: herba epimedii, semen cuscutae, astragalus membranaceus, prepared rehmanniae root, Chinese angelica, peach kernel, safflower, szechuan lovage rhizome. The kidney-tonifying and essence-strengthening soup has the effects of tonifying kidney qi, activating blood and strengthening essence, is mainly used for treating necrospermia caused by kidney essence depletion and poor qi and blood and has quick curative effect, adopts natural Chinese herbal medicinal ingredients, has no side effect to a human body, can strengthen essence and can effectively increase quantity of sperms.

The invention relates to an application of a methylation level of a human CDR1 gene promoter region in preparation of a detection agent for detecting sperm motility. The human CDR1 gene promoter region is located in a region corresponding to the 139866223 to 139868923 sites of a human X chromosome. The analysis and research are carried out on the basis of a whole genome methylation sequencing result, the verification shows that the methylation level of the human CDR1 gene promoter region has significant difference between an asthenozoospermia patient and a healthy person, and the human CDR1 gene promoter region can be used as a molecular marker to diagnose whether a subject suffers from asthenozoospermia or not. When the methylation rate of the region is higher than 0.63, the probability that the subject suffers from asthenozoospermia is high. The molecular marker can provide auxiliary evaluation information for diagnosis of asthenozoospermia, and is combined with other diagnosis indexes to identify whether the subject suffers from asthenozoospermia or not.

The invention provides kidney-invigorating and yang-strengthening silkworm chrysalis health-care medicinal liquor and a preparation method thereof. The liquor comprises three groups of raw material medicines and white spirit: group A: 3-12 parts of silkworm chrysalis, 3-12 parts of silkworm moth, 1-15 parts of fresh cartialgenous, 10-15 parts of fresh fruit of Chinese wolfberry, 2-6 parts of stigma croci and 1.5-3 parts of prepared actinolite; group B: 3-9 parts of ginseng, 10-15 parts of prepared Polygonum multiflorum, 10-30 parts of radix rehmanniae preparata, 3-12 parts of Rhizoma Atractylodis Macrocephalae, 10-15 parts of Eucommia ulmoides, 10-15 parts of Astragalus membranaceus, 3-12 parts of prepared radix aconiti carmichaeli, 6-12 parts of pulp of dogwood fruit, 6-12 parts of herba epimedii, 9-12 parts of teasel root and 3-6 parts of polygala tenuifolia; and group C: 3-9 parts of rhizoma curculiginis, 6-12 parts of Lonicera japonica Thunb, 10-18 parts of cistanche, 6-10 parts of semen allii tuberose, 3-9 parts of fructus cnidii, 2-5 parts of shaved cinnamon bark, 6-12 parts of raspberry, 3-9 parts of Mulberry locust and 6-9 parts of prepared hedgehog hide. The liquor provided by the invention not only solves the problem of tonifying and nourishing kidney, but also solves the problem of necrospermia, asthenospermia and non semen liquefaction within a shorter time.

The invention particularly relates to an application of RSPH9 as a diagnosis marker or a treatment target for oligoasthenozoospermia. Sperm proteins of normal and patients are extracted, bovine serumalbumin is used as a standard substance, and multiple groups of sperm proteins of severe application of RSPH9 as a diagnosis marker or a treatment target for oligoasthenozoospermia diseases are subjected to deep mass spectrometry by using high-resolution biomass spectrometry and a non-labeled quantitative proteomics method; the mass spectrum data are searched by using a protein quantitative analysis method, and the protein in the sperm is identified; and finally, normal and patient sperm proteomes are compared, and screening is conducted to obtain that the contents of RSPH9 in healthy and oligoasthenosperm samples are remarkably different. ROC analysis further verifies that RSPH9 has good specificity as a diagnostic marker, and is expected to be used as a diagnostic marker and a treatmenttarget for severe oligoasthenozoospermia.

The invention provides a novel application of plant fruit pulp. The invention relates to application of plant fruit pulp in testis function protection, application of plant fruit pulp in prevention and/or treatment of oligospermia and asthenospermia, application of plant fruit pulp in protection of male fertility and application of plant fruit pulp in prevention and/or treatment of testis tissue lesion, testosterone level decline, testis function decline, sperm number reduction, asthenospermia and asthenospermia caused by metabolic disorder. The sperm motility rate is reduced; the sperm morphology is abnormal. The plant fruit pulp can effectively prevent and treat symptoms such as testicular tissue lesion, testosterone level decline, testicular hypofunction, sperm number reduction, sperm motility rate reduction and sperm morphology abnormality caused by metabolic disorder. The application provides a basis for protecting testis functions, preventing and/or treating oligospermia and asthenospermia and protecting male fertility by directly utilizing the plant fruit pulp.

The invention discloses an application of a traditional Chinese medicine composition on preparation of medicines or health care products for treating oligoasthenotspermia and infertility of men. The traditional Chinese medicine composition is prepared by prepared tuber of multiflower knotweed, sealwort, prepared rehmannia roots, gordon euryale seeds, placenta hominis, semen sesami nigrum, astragalus membranaceus, tuckahoe, Chinese yams, American ginseng, cochinchinese asparagus roots, radix ophiopogonis, pearls, lamber, fossil fragments, cacumen biotae and black soybeans. Results of screening researches of a large number of pharmacodynamic experiments show that by the traditional Chinese medicine composition, the sperm movement speed can be increased obviously, the number of sperms is increased, and a clinical research result also shows that the traditional Chinese medicine composition has a high treatment effect on oligoasthenotspermia and infertility of men. A test shows that the traditional Chinese medicine composition is reliable in curative effect, small in side effect and high in safety, and has a good clinic application prospect.

The invention discloses a method for improving sperm function of asthenozoospermia by using exosomes, and belongs to the technical field of medicine. The method comprises the following three steps: separation of normal human seminal plasma exosomes, screening and pretreatment of asthenospermia sperms, and intervention of the exosomes on the asthenospermia sperms. The seminal plasma exosomes from the human body are used for intervening sperms in vitro, functions of the sperm motility and the like are improved, so that the asthenozoospermia is intervened and treated through simple non-invasive means such as artificial fertilization, and the fertility outcome of a patient is improved.

The invention relates to a traditional Chinese medicine for treating idiopathic necrospermia sterility. The traditional Chinese medicine can effectively solve the problem how to treat the necrospermiasterility with a good effect, and is prepared from the following raw materials: 13-17g of semen cuscutae, 4-6g of cornu cervi pantotrichum, 13-17g of herba epimedii, 13-17g of fructus lycii, 13-17g of herba cynomorii, 25-35g of radix astragali, 2-4g of hippocampus, 8-12g of radix ginseng rubra, 8-12g of rhizoma polygonati, 8-12g of radix rehmanniae praeparata, 8-12g of radix cyathulae and 4-6g ofscalded leeches. The traditional Chinese medicine has a scientific and reasonable prescription; Monarch, minister, assistant and guide support each other, are strictly matched, and together exert functions of warming kidney and enhancing yang, and dispersing blood stasis and dredging collaterals; and the traditional Chinese medicine is used for effectively treating the necrospermia sterility, hasa good effect, opens up a new way for drugs for treating the necrospermia sterility, and has significant economic and social benefits.

The invention relates to a traditional Chinese medicine composition for treating necrospermia. The composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 to 30 parts of honeysuckle, 10 to 30 parts of the root of red-rooted salvia, 10 to 30 parts of dandelion, 5 to 25 parts of root of rehmannia, 5 to 25 parts of dipsacus asper, 5 to 25 parts of angelica sinensis, 5 to 20 parts of rhizoma anemarrhenae, 5 to 20 parts of golden cypress, 5 to 20 parts of white paeony root, 5 to 25 parts of rhizoma sparganii, 5 to 25 parts of curcuma zedoary, 5 to 25 parts of szechwan chinaberry fruit, 5 to 20 parts of rhizoma corydalis, 5 to 20 parts of caulis spatholobi, 1 to 5 scorpions, 5 to 20 parts of woodlouse, 5 to 20 parts of baked ginger and 5 to 15 parts of licorice root. The composition has the functions of nourishing liver and kidney, invigorating the circulation of blood for scattering stasis, smoothing channels for dredging collaterals as well as warming spleen and stomach for dispelling cold. The composition is obvious in efficacy and reliable in action when being used for treating the necrospermia.

The invention discloses application of a composition in preparting a health care product for improving the sexual function or oligospermia and asthenospermia. The composition comprises herba epimediiextracts, American ginseng extracts and fructus tribuli extracts. Through pharmacological research, it is found that the herba epimedii extracts, the American ginseng extracts and the fructus tribuliextracts are compounded, synergistic interaction between all the components is achieved, the capture number and the ejaculation number can be increased, the erection incubation period is shortened, the effect of improving the sexual function is achieved, the effects of improving the sperm motility and increasing the amount of sperms are achieved, and the composition has a good effect on improvement of the oligospermia and asthenospermia.

The invention provides a method for preventing and treating aspermia and necrospermia of a breeding boar. The method employs a combination of a traditional Chinese medicine therapy and a western medical therapy. According to the western medical therapy, 100 to 150 mg of a testosterone propionate injection is used for cervical intramuscular injection once every other day, and altogether four injection operations are carried out; and three to five vitamin C capsules and two to three vitamin AD capsules are simultaneously fed with a feed each time, and the capsules are fed for a consecutive period of seven days. According to the traditional Chinese medicine therapy, traditional Chinese medicinal raw materials are mixed and powdered and then orally taken by the breeding boar, wherein the traditional Chinese medicinal raw materials consist of, by weight, 25 to 35 parts of dodder seeds, 25 to 35 parts of Chinese magnoliavine fruit, 25 to 35 parts of wolfberries, 25 to 35 parts of raspberries, 45 to 55 parts of Herba Epimedii, 45 to 55 parts of eucommia bark and 20 to 30 parts of cassia bark; one dosage of the powdered traditional Chinese medicinal raw materials is taken each day and taken twice each day; and the powdered traditional Chinese medicinal raw materials are taken for consecutive period of five days. With the method provided by the invention, breeding boars with aspermia and necrospermia have more sensitive visual sense and hearing and are fond of standing and moving; little foam saliva flows out from the mouths of the breeding boars; normally after five days, the breeding boars have good appetite, improved sexual desire and a body temperature increase of about 0.3 DEG C, and the result of microscopic examination of seminal fluids shows that a great number of sperms are moving; and normally, aspermia and necrospermia can be thoroughly treated after continuous treatment for 7 to 10 days.

The invention relates to traditional Chinese medicine (TCM) pills for treating necrospermia and a preparation method thereof. The TCM pills are prepared from the following medicines: radix astragali, angelica sinensis, China dodder, oriental water plantain rhizome, ground beetle, sea horse, sea otter, Chinese magnoliavine fruit, glue of tortoise plastron, white peony root, boiled ginseng, desertliving cistanche, prepared rhizome of rehmannia, mesona chinensis, morinda root, Chinese yam, flickingeria comata, lotus seeds, deerhorn glue, antler and human placenta. The preparation method is characterized by comprising the following steps of: mixing the medicines together and grinding the medicines into powder; and then taking 200g of honey, decocting the honey in a hot pot until the honey reaches 80 DEG C, after the honey is decocted and cooled to 10 DEG C, pouring the powder into the honey and stirring the materials uniformly to prepare 60 pills. Patients take the pills with warm water twice a day, one pill in the morning and one pill in the evening. Continuous 30 days is a course of treatment. The patients take the pills for one-three courses of treatment and necrospermia can be cured. Alcohols are prohibited and contact with paints is avoided during medicine taking. Clinical use demonstrates that after being taken by the patients, the pills can be used for thoroughly curing necrospermia and have particularly obvious effect, no toxic or side effect and low cost.

The invention relates to application of methylation level of a human PKP3 gene promoter region in preparing a detection agent for preparing sperm activity. The human PKP3 gene promoter region is a region corresponding to space from 392017th to 394717th of a human 11th chromosome. Analysis, research and verification on the basis of whole genome methylation sequencing results finds that the methylation level of the human PKP3 gene promoter region can serve as a molecular marker to detect the sperm activity, and when all methylation sites of the region are not completely methylated, it can be thought that activity of corresponding sperms is weak. The molecular marker can provide assistant evaluation information for diagnosis of asthenozoospermia and selection of sperms before artificial fertilization.

The invention provides a yin-nourishing and sperm-producing decoction. The yin-nourishing and sperm-producing decoction has the functions of clearing internal heat and resolving phlegm, and nourishing yin and producing sperms, and is mainly used for treating necrospermia due to heat stagnation in lower jiao and impairment of yin caused by pyrophlegm and male infertility with quick curative effect and excellent effect; the traditional Chinese medicine composition is prepared compatibly from a plurality of medicinal raw materials by weight, such as rhizoma dioscoreae hypoglaueae, semen plantaginis, polygala tenuifolia, acorus tatarinowii, barbary wolfberry fruit, cistanche and epimedium. The yin-nourishing and sperm-producing decoction is used for clearing internal heat and resolving phlegm and nourishing yin and producing sperms for the male, and used for treating necrospermia due to heat stagnation in lower jiao and impairment of yin caused by pyrophlegm and male infertility; the natural Chinese herbal medicinal ingredients have no side effect on the body; the prescription is capable of strengthening the sperms and effectively increasing the amount of sperms.

The invention provides a novel application of plant seed oil. The invention relates to application of plant seed oil in testis function protection, application of plant seed oil in prevention and/or treatment of oligospermia and asthenospermia, application of plant seed oil in protection of male fertility and application of plant seed oil in prevention and/or treatment of testis tissue lesion, testosterone level decline, testis function decline, sperm number reduction, and asthenospermia caused by metabolic disorder. The sperm motility rate is reduced; the sperm morphology is abnormal. The plant seed oil can effectively prevent and treat symptoms such as testicular tissue lesion, testosterone level decline, testicular hypofunction, sperm number reduction, sperm motility rate reduction and sperm morphology abnormality caused by metabolic disorder. The application provides a basis for protecting testis functions, preventing and/or treating oligospermia and asthenospermia and protecting male fertility by directly utilizing the plant seed oil.

The invention discloses application of maca and maca polysaccharide in treating testis spermatogenesis disorders, and particularly relates to the application of the maca and the maca polysaccharide intreating the spermatogenesis disorders including oligospermia, asthenozoospermia and azoospermia, especially azoospermia caused by medicine. According to the application, an azoospermia model of a busulfan-induced mouse is used for verifying the improvement effect of the maca and the maca polysaccharide on the busulfan-induced azoospermia mouse.

The invention discloses an application of a compound in treating asthenozoospermia, which is an application of a compound shown as a structural formula I or pharmaceutically acceptable salt thereof inpreparation of a medicine or a medicine box for promoting sperm motility, prolonging sperm motility time and/or prolonging survival time of unfrozen sperms, and also discloses an application of the compound in preparation of the medicine or the medicine box for assisting reproduction, or in preparation of the medicine or the medicine box for treating asthenozoospermia.