31 results about "Azoospermatism" patented technology

The invention belongs to the technical field of traditional Chinese medicines, in particular discloses a Chinese medicinal composition for treating necrospermia, asthenospermia oligospermia, or aspermatism, which comprises the following raw material medicaments in part by weight: 10 to 20 parts of epimedium brevicornum, 10 to 20 parts of medicinal indianmulberry root, 10 to 20 parts of desertliving cistanche, 10 to 20 parts of south dodder seed, 10 to 20 parts of siberian solomonseal rhizome, 10 to 20 parts of Chinese angelica, 7 to 13 parts of common curculigo rhizome, 8 to 16 parts of Chinese thorowax root, 8 to 16 parts of large-headed atractylodes rhizome, 14 to 26 parts of astragalus, 14 to 26 parts of radix rehmanniae praeparata, 14 to 26 parts of dioscorea root, 3 to 8 parts of liquorice root, 5 to 13 parts of glossy privet fruit, 10 to 20 parts of plantain seed, 10 to 20 parts of palmleaf raspberry fruit, 20 to 40 parts of root of red-rooted salvia, 8 to 16 parts of eucommia bark, 7 to 13 parts of baicalin, 3 to 8 parts of salivia chinensis, 6 to 13 parts of Indian buead and 6 to 14 parts of oriental waterplantain rhizome. The Chinese medicinal composition has the effects of warming and invigorating kidney yang with tonifying qi and invigorating blood circulation and supplementing essence and replenishing marrow, and has the advantages of simple preparation, convenientadministration, good curative effect and no toxic or side effect.

The invention relates to a method and a kit for diagnosing male infertility caused by Piwil1 gene mutation. The invention discloses a gene related to male infertility such as azoospermia, namely the Piwil1 gene. Moreover, the fact that mutation at multiple positions of the Piwil1 gene can cause the occurrence of male infertility is identified. Thus, the Piwil1 gene can be used as a target gene fordiagnosing male infertility, and also can be applied to the development for the treatment medicines effective for the diseases. According to the technical scheme, explanation is given for the mechanism that PIwIl1 participates in the histone substitution by protamine for the first time.

The invention discloses a pathogenic mutation of hereditary gametogenesis disorder and a detection reagent thereof. A mutated Pof1b gene, the mutated Pof1b gene is located on chromosome X, is a deletion mutation c.312_316delp.S104fs, and the gene number of the wild-type Pof1b gene in the Ensemble database is: ENSG00000124429, where the Pof1b gene of the deletion mutation is physically The position is the third exon, the chrX-84622737-84622742 base is missing five bases TACAT, and the subsequent sequence causes a frameshift mutation. The mutated Pof1b gene or the mutated POF1B protein is used as a detection target in the preparation of auxiliary diagnostic reagents or detection equipment for male non-obstructive azoospermia or female hereditary primary ovarian insufficiency.