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Application of maca extract and maca polysaccharide in preparation of product for treating spermatogenesis dysfunction diseases

A technology of maca extract and dysfunction, applied in the field of biomedicine, can solve problems such as inapplicability to male children, increased risk of genetic defect transmission, harsh conditions for in vitro cultured organs, etc.

Inactive Publication Date: 2021-01-01
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For patients with spermatogenesis dysfunction caused by drug-induced testicular damage, there are no good drugs to improve testicular damage
Semen cryopreservation is a way out for male patients, but this method is not suitable for male children with malignant diseases such as leukemia
The emergence of assisted reproductive technology allows patients to obtain fertility opportunities, but not all patients can find suitable sperm in their bodies, and sperm retrieval is an invasive operation that causes certain mechanical damage to patients and bypasses the natural selection mechanism of the sperm formation process , increasing the risk of passing the genetic defect on to the next generation
Although some scholars put forward the theory of in vitro organ culture, the current technology is not yet mature, and the conditions for in vitro organ culture are harsh, the cost is high, and the clinical application potential remains to be studied

Method used

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  • Application of maca extract and maca polysaccharide in preparation of product for treating spermatogenesis dysfunction diseases
  • Application of maca extract and maca polysaccharide in preparation of product for treating spermatogenesis dysfunction diseases
  • Application of maca extract and maca polysaccharide in preparation of product for treating spermatogenesis dysfunction diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation of maca extract

[0029] Select Yunnan Lijiang maca rhizomes of uniform size, crush them and pass through a 60-mesh sieve. Weigh 1 kg of maca powder, extract three times under reflux with 70% industrial ethanol of 10 times the volume, combine the extracts, concentrate by rotary evaporation to obtain an extract, disperse the extract with double distilled water, and dissolve into a suspension.

Embodiment 2

[0030] Embodiment 2: the preparation of maca polysaccharide

[0031] Select Yunnan Lijiang maca rhizomes of uniform size, crush them and pass through a 60-mesh sieve. Weigh 1 kg of maca powder, heat and reflux extract three times with 60%-80% industrial ethanol, combine the extracts, concentrate to 1L by rotary evaporation, slowly add 50%-70% ethanol for gradient sedimentation, and the final ethanol concentration is 70%-80 %, placed at room temperature for 20-24 hours, filtered with suction, and the filtrate was rotary evaporated to 500 mL, continued alcohol precipitation, adjusted the ethanol concentration to 70-80%, placed at room temperature for 20-24 hours, and filtered with suction. Combine the two precipitates, dissolve them in double-distilled water, then spin-steam them until there is no alcohol smell, and dissolve them again to 1-2L to form a maca crude polysaccharide solution.

Embodiment 3

[0032] Example 3: Using a mouse model to detect the effect of maca and maca polysaccharides in improving spermatogenesis disorders.

[0033] Busulfan modeling principle:

[0034] (1) animals

[0035] ICR normal mice, male, weighing 20-25g, 7-8 weeks old, SPF grade

[0036] (2) Mouse feeding conditions

[0037] All mice were free to forage for food and drink water, and were reared at room temperature (25±2)°C and relative humidity of 40%-70%. The experiment was started after 12 hours of alternating light and dark, and the mice were fed adaptively for one week.

[0038] (3) Mouse grouping and model setting

[0039] After one week of adaptive feeding, ICR mice were randomly divided into four groups according to body weight: blank group (control), busulfan model group (Busulfan, Bu), and melatonin positive control group (MT, Melatonin). Melanin, L-carnitine and its derivatives have a certain protective effect on spermatogenic dysfunction caused by busulfan, but L-carnitine has ...

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PUM

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Abstract

The invention discloses application of maca and maca polysaccharide in treating testis spermatogenesis disorders, and particularly relates to the application of the maca and the maca polysaccharide intreating the spermatogenesis disorders including oligospermia, asthenozoospermia and azoospermia, especially azoospermia caused by medicine. According to the application, an azoospermia model of a busulfan-induced mouse is used for verifying the improvement effect of the maca and the maca polysaccharide on the busulfan-induced azoospermia mouse.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the use of maca extract and maca polysaccharide in treating spermatogenic dysfunction. Background technique [0002] According to the report of the World Health Organization, 15% of couples of childbearing age worldwide suffer from infertility problems, and the population of fertility disorders has increased significantly, becoming the third largest disease after tumors and cardiovascular and cerebrovascular diseases. Among them, 50% are male factors, which are called male infertility in medicine, and become a growing trend year by year. [0003] The causes of male reproductive disorders are complex. According to the description of modern medicine, they are divided into four categories based on the different processes of fertilization: spermatogenesis, sperm delivery, sperm and egg integration, and sexual dysfunction. [0004] Existing studies believe that the main causes of...

Claims

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Application Information

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IPC IPC(8): A61K36/31A61K31/715A61P15/08
CPCA61K31/715A61K36/31A61K2236/333A61K2236/39A61K2236/53A61P15/08
Inventor 余伯阳戚进陈媛媛
Owner CHINA PHARM UNIV
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